Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
JAK2 Inhibition Mediates Clonal Selection of RAS Pathway Mutations in Myeloproliferative Neoplasms
[Nature Communications] To evaluate ruxolitinib’s impact on myeloproliferative neoplasm clonal evolution, researchers interrogated a myelofibrosis patient cohort with longitudinal molecular evaluation and discover that ruxolitinib is associated with clonal outgrowth of RAS pathway mutations.
EMP1 Safeguards Hematopoietic Stem Cells by Suppressing Sphingolipid Metabolism and Alleviating Endoplasmic Reticulum Stress
[Nature Communications] Investigators demonstrated that suppression of endoplasmic reticulum stress improves the functions of HSCs and protects HSCs against ionizing radiation-induced injury.
Bone Marrow Neutrophil Density Regulates Myelopoiesis during Obesity and Weight Loss
[Journal of Experimental Medicine] The authors showed that obesogenic stimuli promote adipose tissue macrophages to recruit neutrophils from the bone marrow in mice.
ADH5/ALDH2 Dehydrogenases and DNA Polymerase Theta Protect Normal and Malignant Hematopoietic Cells from Formaldehyde Challenge: Therapeutic Implications
[Leukemia] Investigators showed that DNA polymerase theta cooperates with alcohol dehydrogenase 5 (ADH5) and aldehyde dehydrogenase 2 (ALDH2) to protect healthy and malignant hematopoietic stem and progenitor cells challenged by formaldehyde.
Age-Dependent Phenotypic and Molecular Evolution of Pediatric MDS Arising from GATA2 Deficiency
[Blood Cancer Journal] To elucidate genotype-phenotype associations and identify new genetic risk factors for myelodysplastic syndrome (MDS), researchers analyzed 218 individuals with germline heterozygous GATA2 variants.
AK2-Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis
[European Journal of Immunology] The authors established and characterized a haematopoiesis-specific conditional Ak2-knockout mouse model to provide a model system to study the molecular pathophysiology of reticular dysgenesis.
The Hallmarks of Hematopoietic Stem Cell Transplantation for Pediatric Acute Myeloid Leukemia
[Leukemia] Investigators comprehensively discuss indications for HSC transplantation and its modalities in pediatric AML by examining past, current, and future strategies for disease- and response-related stratification.
LLS Invests Nearly $5 Million in Research Committed to Increasing Clinical Trial Access & Participation
[Leukemia & Lymphoma Society] The Leukemia & Lymphoma Society’s (LLS) Equity in Access Research Program is collectively awarding nearly $5 million to health services researchers focused on identifying interventions that can be effective in increasing participation in therapeutic cancer clinical trials
Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplant with Different Stem Cell Sources in Infant Acute Myeloid Leukemia
[Scientific Reports] Researchers emphasized the efficacy of HSC transplantation in the treatment of infant AML, with higher overall survival rates compared to childhood AML. They support umbilical cord blood as a viable stem cell source.
Mature Megakaryocytes Acquire Immune Characteristics in a Mouse Model of Aplastic Anemia
[Blood Advances] In a mouse model of immune bone marrow failure, researchers observed the unexpected persistence of megakaryocytes despite thrombocytopenia.
BRD4 Acts As a Transcriptional Repressor of RhoB to Inhibit Terminal Erythropoiesis
[Journal of Hematology & Oncology] Scientists used a high-throughput small molecule screen in primary CD34+-derived human erythroblasts to identify targets that promote terminal erythropoiesis.
The WWP1-JARID1B Axis Sustains Acute Myeloid Leukemia Chemoresistance
[Proceedings of The National Academy of Sciences of The United States of America] To uncover substrates mediating the oncogenic activity of WWP1 in AML, scientists performed a proteomic analysis that identify the histone demethylase KDM5B/JARID1B as a candidate target.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
