Erythroid Overproduction of Erythroferrone Causes Iron Overload and Developmental Abnormalities in Mice

Scientists generated three lines of transgenic mice with graded erythroid overexpression of erythroferrone and showed that they developed dose-dependent iron overload, impaired hepatic BMP signaling and relative hepcidin deficiency.
[Blood]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Incidence and Prognosis of Clonal Hematopoiesis in Patients with Chronic Idiopathic Neutropenia

Researchers investigated the frequency and clinical significance of mutations of genes implicated in myeloid malignancies using next-generation sequencing in patients with chronic idiopathic neutropenia with a long follow-up.
[Blood]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling

The authors reported an adverse effect of NEAT1, showing that the short isoform, NEAT1_1 suppressed acute myeloid leukemia (AML) development. NEAT1_1 was downregulated in leukemia stem cells and its decreased expression correlated with recurrence in AML patients.
[Advanced Science]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Immune Landscape in BCR-ABL Negative Myeloproliferative Neoplasms: Inflammation, Infections and Opportunities for Immunotherapy

Scientists focus on the immune landscape in patients with myeloproliferative neoplasms – the role of inflammation in disease pathogenesis, susceptibility to infection and emerging strategies for therapeutic immune modulation.
[British Journal of Haematology]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Advances in Acute Myeloid Leukemia

Investigators discuss important updates in diagnostic and disease classifications that reflect new understanding of the biology of acute myeloid leukemia, its mutational heterogeneity, some important genetic and environmental risk factors, and new treatment options including cytotoxic chemotherapy, novel targeted agents, and cellular therapies.
[Bmj Open]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Clinical Evolution, Genetic Landscape and Trajectories of Clonal Hematopoiesis in SAMD9/SAMD9L Syndromes

The authors investigated a clinically annotated pediatric myelodysplastic syndromes cohort to define the prevalence, genetic landscape, phenotype, therapy outcome and clonal architecture of SAMD9/9L syndromes.
[Nature Medicine]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

BUB1B and circBUB1B_544aa Aggravate Multiple Myeloma Malignancy through Evoking Chromosomal Instability

Investigators elucidated that the expression of BUB1B increased strikingly in multiple myeloma patients and was closely correlated with poor outcomes. Overexpression of BUB1B facilitated cellular proliferation and induced drug resistance in vitro and in vivo, while genetic targeting BUB1B abrogated this effect.
[Signal Transduction and Targeted Therapy]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Myeloid-Derived Suppressor Cells as Immunosuppressive Regulators and Therapeutic Targets in Cancer

The authors shed new light on recent advances in the biological characteristics and immunosuppressive functions of myeloid-derived suppressor cells (MDSCs) and propose an overview of current MDSCs-targeting therapies so as to provide new ideas for cancer treatment.
[Signal Transduction and Targeted Therapy]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Spliceosome Factor sart3 Regulates Hematopoietic Stem/Progenitor Cell Development in Zebrafish through the p53 Pathway

Investigators characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell defects and found that sart3 was the causative gene.
[Cell Death & Disease]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Aberrantly Reduced Expression of miR-342-5p Contributes to CCND1-Associated Chronic Myeloid Leukemia Progression and Imatinib Resistance

Scientists used next-generation sequencing to explore endogenous miRNAs in chronic myeloid leukemia (CML) patients versus healthy volunteers, and miR-342-5p was identified as the primary target. They found that miR-342-5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML.
[Cell Death & Disease]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

ULK1 Inhibition Promotes Oxidative Stress–Induced Differentiation and Sensitizes Leukemic Stem Cells to Targeted Therapy

The authors showed that deletion of autophagy-inducing kinase unc-51–like autophagy activating kinase 1 (ULK1) reduced growth of cell line and patient-derived xenografted chronic myeloid leukemia cells in mouse models.
[Science Translational Medicine]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share