Ex Vivo Editing of Human Hematopoietic Stem Cells for Erythroid Expression of Therapeutic Proteins

Scientists describe an ex vivo editing approach to achieve efficient gene targeting in human hematopoietic stem/progenitor cells and robust expression of clinically relevant proteins by the erythroid lineage.
[Nature Communications]
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Utilization and Cost Implications of Hematopoietic Progenitor Cells Stored for a Future Salvage Autologous Transplantation or Stem Cell Boost in Myeloma Patients

In this single-center retrospective study, researchers analyzed the utilization of hematopoietic progenitor cells (HPCs) collected and stored at the time of first autologous hematopoietic cell transplantation in patients with myeloma and the cost implications of HPC collection targets sufficient for two transplants.
[Biology of Blood and Marrow Transplantation]
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Gemfibrozil Induces Anemia, Leukopenia and Reduces Hematopoietic Stem Cells via PPAR-α in Mice

Investigators analyzed bone marrow and found that gemfibrozil reduced erythrocytes and hematopoietic stem cells in wild-type mice but not in PPAR-alpha-knockout mice, while increased colony-forming units were observed only in wild-type mice treated with gemfibrozil.
[International Journal of Molecular Sciences]
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ElsaLys Biotech Announces Submission of Biologics License Application to FDA for LEUKOTAC® (Inolimomab) for the Treatment of Graft-versus-Host Disease in Adult Patients

ElsaLys Biotech announced the FDA agreement to start the LEUKOTAC® submission process for a Biologics License Application for the treatment of steroid-refractory acute graft-versus-host disease, grade II-IV adult patients.
[ElsaLys Biotech SA]
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Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the Treatment of Hematologic Malignancies in China

Ascentage Pharma announced that the Phase Ib study of the company’s novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia, or relapsed/progressed high/very high risk myelodysplastic syndrome has dosed its first patient in China.
[Ascentage Pharma]
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The Role of Clonal Hematopoiesis in Cardiovascular Diseases: Epidemiology and Experimental Studies

The authors summarize the current understanding of the importance of clonal hematopoiesis as a new causal risk factor for atherosclerotic cardiovascular disease and heart failure.
[Journal of Internal Medicine]
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Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells

C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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90Y-Labeled Anti-CD45 Antibody Allogeneic Hematopoietic Cell Transplantation for High-Risk Multiple Myeloma

To improve disease control without increasing the toxicity of a reduced-intensity allogeneic hematopoietic cell transplantation in multiple myeloma, a Phase I trial was performed using an antibody-radionuclide conjugate targeting CD45 as conditioning.
[Bone Marrow Transplantation]
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Upfront Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma with del(17p) and t(4;14): A Study from the CMWP-EBMT

Researchers analyzed newly diagnosed multiple myeloma patients with del(17p) and/or t(4;14) undergoing either upfront single autologous, tandem autologous or tandem autologous/reduced-intensity allogeneic stem cell transplantation.
[Bone Marrow Transplantation]
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Cell Type Specific Novel LncRNAs and CircRNAs in the BLUEPRINT Hematopoietic Transcriptomes Atlas

The authors analyzed the BLUEPRINT consortium RNA- seq data for mature hematopoietic cell types. The data comprised 90 total RNA-seq samples, each composed of one of 27 cell types, and 32 small RNA-seq samples, each composed of one of 11 cell types.
[Haematologica]
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