Gamida Cell Ltd. announced that the Phase III study of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant, met all three of its secondary endpoints.
[Gamida Cell Ltd.]
1254621 nan items 1 apa default asc 1
Scientists made an attempt to find out the osteoblastic niche related alterations in the myelodysplastic bone marrow through mainly flowcytometric and fluorescent microscopic studies.
[Molecular and Cellular Biology]
1254621 7XX646KA items 1 apa default asc 1
bluebird bio, Inc. announced that the European Medicines Agency accepted the company’s MAA for its investigational elivaldogene autotemcel gene therapy for the treatment of patients with CALD.
[bluebird bio, Inc.]
1254621 nan items 1 apa default asc 1
Researchers report the design and in vivo performance of systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA, for the silencing of genes in bone-marrow endothelial cells.
[Nature Biomedical Engineering]
6445218 5C9VAHHK items 1 apa default asc 1
Krohn-Grimberghe, M., Mitchell, M. J., Schloss, M. J., Khan, O. F., Courties, G., Guimaraes, P. P. G., Rohde, D., Cremer, S., Kowalski, P. S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S. P., Wojtkiewicz, G. R., Nayar, R., Frodermann, V., Hulsmans, M., … Nahrendorf, M. (2020). Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering, 1–14. https://doi.org/10.1038/s41551-020-00623-7 Cite
The authors showed that, during mouse acute liver injury, the density of megakaryocyte in the bone marrow increases following an increase in circulating platelet-derived microparticles, but without thrombopoietin upregulation.
1254621 MJNAKY45 items 1 apa default asc 1
Qu, M., Zou, X., Fang, F., Wang, S., Xu, L., Zeng, Q., Fan, Z., Chen, L., Yue, W., Xie, X., & Pei, X. (2020). Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p. Nature Communications, 11(1), 4964. https://doi.org/10.1038/s41467-020-18802-0 Cite
Scientists performed a targeted CRISPR-Cas9-based sgRNA screen to identify candidate genes that counteract the decreased repopulating capacity of hematopoietic stem and progenitor cells during gene therapy.
1254621 XVV8TPX8 items 1 apa default asc 1
Researchers report that the proportions of Lin-CD34+38– hematopoietic multipotent cells and of Lin-CD34+CD38+ hematopoietic progenitors cells are highly variable between individuals but stable over long periods of time, in both healthy individuals and sickle cell disease patients.
1254621 T4WLXWJE items 1 apa default asc 1
Minniti, C. P., Tolu, S. S., Wang, K., Yan, Z., Robert, K., Zhang, S., Crouch, A. S., Uehlinger, J., Manwani, D., & Bouhassira, E. E. (2020). HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines. Cells, 9(10), 2199. https://doi.org/10.3390/cells9102199 Cite
Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells.
Researchers report that partial disruption of Separase distinctly alters the functional characteristics of hematopoietic stem/progenitor cells.
1254621 IGP9XSAI items 1 apa default asc 1
Avalon GloboCare Corp. provided a clinical update on its chimeric antigen receptor (CAR) T-cell therapy and allogeneic mesenchymal stromal cell (MSC) therapy programs following successful completion of its Phase I clinical trial of AVA-001, the company’s leading CAR T-cell therapy candidate in development for patients with relapsed/refractory B-cell lymphoblastic leukemia.
[Avalon GloboCare Corp. (GlobeNewswire, Inc.)]
Using a MLL-AF9 knock-in mouse model, researchers discovered that consumption of a high-fat diet accelerates the risk of developing acute myeloid leukemia.
1254621 CSZWVS4N items 1 apa default asc 1
Hermetet, F., Mshaik, R., Simonet, J., Callier, P., Delva, L., & Quéré, R. (2020). High-fat diet intensifies MLL-AF9 -induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells. Scientific Reports, 10(1), 16187. https://doi.org/10.1038/s41598-020-73020-4 Cite