Pre-Configuring Chromatin Architecture with Histone Modifications Guides Hematopoietic Stem Cell Formation in Mouse Embryos

The authors performed multi-omics dissection of the hematopoietic stem cell (HSC) ontogeny trajectory across early arterial endothelial cells (ECs), hemogenic ECs, pre-HSCs and long-term HSCs in mouse embryos.
[Nature Communications]
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Hemolysis Contributes to Anemia during Long-Duration Space Flight

Researchers showed that space flight was associated with persistently increased levels of products of hemoglobin degradation, carbon monoxide in alveolar air and iron in serum, in 14 astronauts throughout their 6-month missions onboard the International Space Station.
[Nature Medicine]
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Sorting Nexin 24 Is Required for α-Granule Biogenesis and Cargo Delivery in Megakaryocytes

The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.
[Haematologica]
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HMCES Safeguards Genome Integrity and Long-Term Self-Renewal of Hematopoietic Stem Cells during Stress Responses

Investigators showed that HMCES, a novel shield of abasic sites, plays pivotal roles in overcoming the challenge of HSC stress responses upon HSC activation.
[Leukemia]
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Synergistic Activity of Combined Inhibition of Anti-apoptotic Molecules in B-cell Precursor ALL

When analyzing the effects of BH3-mimetics selectively targeting BCL-XL and MCL-1 alone or in combination with the BCL-2 inhibitor venetoclax, heterogeneous sensitivity to either of these inhibitors was found in ALL cell lines and in patient-derived xenografts.
[Leukemia]
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UK Sickle Cell Gene Therapy Research Awarded $3.1M Grant

Researchers at the University of York in the UK have been awarded a $3.1 million grant to accelerate research supporting stem cell gene therapy to treat sickle cell disease.
[Sickle Cell Disease News]
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Clonal Evolution in Patients Developing Therapy-Related Myeloid Neoplasms Following Autologous Stem Cell Transplantation

Clonal hematopoiesis was associated with increasing age and with a factor 6 increase in the risk of developing therapy-related myeloid neoplasms following autologous stem cell transplantation.
[Bone Marrow Transplantation]
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Century Therapeutics and Bristol Myers Squibb Enter into a Strategic Collaboration to Develop iPSC-Derived Allogeneic Cell Therapies

Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.
[Century Therapeutics]
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FDA Grants Regenerative Medicine Advanced Therapy (RMAT) Designation to AlloVir’s Posoleucel for the Treatment of Adenovirus (AdV) Infections in Adults and Children Post-Allogeneic Stem Cell Transplantation

AlloVir, Inc. announced that the US FDA has granted its lead multi-virus specific T cell therapy, posoleucel, RMAT designation for the treatment of AdV infection following allogeneic hematopoietic stem cell transplant. The designation is based on positive results from the Phase II CHARMS study.
[AlloVir, Inc.]
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Starton Therapeutics Receives Clinical Trial Authorization in Europe to Initiate Phase I Clinical Trial of STAR-LLD Continuous Delivery Lenalidomide

Starton Therapeutics, Inc. announced that it has received its first Clinical Trial Authorization in the Netherlands to initiate a Phase I study evaluating STAR-LLD, a continuous delivery lenalidomide in development to expand the standard of care for the most common blood cancers, multiple myeloma and chronic lymphocytic leukemia, bioavailability in human subjects.
[Starton Therapeutics, Inc.]
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Deubiquitylase USP12 Induces Pro-Survival Autophagy and Bortezomib Resistance in Multiple Myeloma by Stabilizing HMGB1

Researchers identified an important role of the deubiquitylase ubiquitin-specific protease-12 (USP12) in pro-survival autophagy and resultant bortezomib resistance in multiple myeloma by stabilizing high mobility group box-1 (HMGB1).
[Oncogene]
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