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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Non-Viral DNA Delivery and TALEN Editing Correct the Sickle Cell Mutation in Hematopoietic Stem Cells
[Nature Communications] The authors developed a GMP-compatible TALEN-mediated gene editing process enabling efficient HBB correction via a DNA repair template while minimizing risks associated with HBB inactivation.
GATA2 Heterozygosity Causes an Epigenetic Feedback Mechanism Resulting in Myeloid and Erythroid Dysplasia
[British Journal of Haematology] To explore the impact of GATA2 haploinsufficiency on hematopoiesis, investigators generated a zebrafish model carrying a heterozygous mutation of gata2b, an ortholog of GATA2.
HALP Score as a Novel Prognostic Factor for Patients with Myelodysplastic Syndromes
[Scientific Reports] Scientists retrospectively analyzed data from 130 newly diagnosed myelodysplastic syndrome patients evaluated and classified under hemoglobin, albumin, lymphocyte, and platelet (HALP) score.
Roxadustat versus Placebo for Patients with Lower-Risk Myelodysplastic Syndrome: MATTERHORN Phase III, Double-Blind, Randomized Controlled Trial
[American Journal of Hematology] The MATTERHORN randomized, double-blind, phase III trial evaluated roxadustat versus placebo for patients with transfusion-dependent, lower-risk myelodysplastic syndromes/neoplasms.
Integrated Genetic, Epigenetic, and Immune Landscape of TP53 Mutant AML and Higher Risk MDS Treated with Azacitidine
[Therapeutic Advances in Hematology] Researchers performed extensive molecular, epigenetic, and immunologic assays on a well-annotated clinical trial dataset of 61 patients with TP53-mutated disease and 144 TP53 wild-type patients, all of whom received azacitidine-based therapy.
Systemic and Local Regulation of Hematopoietic Homeostasis in Health and Disease
[Nature Cardiovascular Research] The adaptability of the hematopoietic system is required to respond to the needs of the host, whether to maintain normal physiology or during periods of physical, psychosocial or environmental stress.
FDA Approves Blincyto® (Blinatumomab) in CD19-Positive Philadelphia Chromosome-Negative B-cell Precursor Acute Lymphoblastic Leukemia (B-ALL) in the Consolidation Phase
[Amgen] Amgen announced the US FDA has approved BLINCYTO® for the treatment of adult and pediatric patients one month or older with CD19-positive Philadelphia chromosome-negative B-ALL in the consolidation phase, regardless of measurable residual disease status.
Stromal Cells Engineered to Express T Cell Factors Induce Robust CLL Cell Proliferation In Vitro and in PDX Co-Transplantations Allowing the Identification of RAF...
[Leukemia] Investigators prepared a novel model based on mimicking T cell signals in vitro and in patient-derived xenografts. Six supportive cell lines were prepared by engineering HS5 stromal cells with stable expression of human CD40L, IL4, IL21, and their combinations.
Virus Specific T Cell Therapy to Treat Refractory Viral infections in Solid Organ Transplant Recipients
[American Journal of Transplantation] The authors provide a state-of-the-art update of the current virus specific T cell pipeline and translational research that is likely to lead to further treatment options for viral infections in solid organ transplant recipients.
Immunotherapy for Hepatocellular Carcinoma: The Next Evolution in Expanding Access to Liver Transplantation
[Journal of Hepatology] Investigators discuss the mechanisms supporting combination immunotherapy, summarize key recent clinical data from major immunotherapy trials, and explore how immunotherapy can be applied in the neoadjuvant setting prior to liver transplantation in selected high-risk patients.
Wnt Signaling Couples G2 Phase Control with Differentiation during Hematopoiesis in Drosophila
[Developmental Cell] Using genetic dissection in Drosophila, investigators showed that a Wnt6/EGFR-signaling network simultaneously controlled progenitor growth, proliferation, and differentiation.
Dynamic Tracking of Native Polyclonal Hematopoiesis in Adult Mice
[eLife] Researchers optimized a method for quantifying a wide range of hematopoietic precursors. Assuming the random induction of a stable label in precursors following a binomial distribution, the estimation depended on the inverse correlation between precursor numbers and the variance of precursor labeling among independent samples.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
