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Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Efficacy of JAK1/2 Inhibition in Murine Myeloproliferative Neoplasms Is Not Mediated by Targeting Oncogenic Signaling
[Nature Communications] Investigators developed two JAK2-V617F-driven myeloproliferative neoplasm mouse models harboring ruxolitinib resistance mutations.
WNK1 Signaling Regulates Amino Acid Transport and mTORC1 Activity to Sustain Acute Myeloid Leukemia Growth
[Nature Communications] Scientists showed that genetic depletion and pharmacological inhibition of WNK1 or its downstream phosphorylation targets OXSR1 and STK39 strongly reduce cell proliferation and induce apoptosis in leukemia cells in vitro and in vivo.
Emerging Roles of Protein Arginine Methyltransferase in Multiple Myeloma
[Molecular Therapy Oncology] The authors provide an overview of the functions of protein arginine methyltransferase (PRMTs) in multiple myeloma pathology and discuss the development of PRMT inhibitors currently being evaluated in clinical trials.
KRAS May Facilitate Transformation of Chronic Lymphocytic Leukemia to Histiocytic Sarcoma with Indeterminate Dendritic Cell Features
[American Journal of Clinical Pathology] Scientists investigated the molecular mechanism underlying transformation of chronic lymphocytic leukemia to histiocytic sarcoma with indeterminate dendritic cell features.
CD97-Directed CAR-T Cells with Enhanced Persistence Eradicate Acute Myeloid Leukemia in Diverse Xenograft Models
[Cell Reports Medicine] Researchers proposed CD97 as a potential target for CAR-T therapy against acute myeloid leukemia (AML) based on its broader and higher expression on AML cells compared to normal hematopoietic stem and progenitor cells.
Lentiviral Gene Therapy with Reduced-Intensity Conditioning for Sickle Cell Disease: A Phase 1/2 Trial
[Nature Medicine] Investigators reported results of seven patients treated in a first-in-human Phase I/II study for sickle cell disease using reduced-intensity conditioning transplant of autologous hematopoietic stem cells genetically modified with a lentiviral vector, with 2–7 yr of follow-up.
Aberrant Engagement of P-Selectin Drives Hematopoietic Stem Cell Aging in Mice
[Nature Aging] The authors uncovered that cell surface presentation of P-selectin increases in a large fraction of aging HSCs driven by a proinflammatory milieu in mice.
Phase I/II Study of High-Dose Palifermin for GVHD Prophylaxis in Patients Undergoing HLA-Matched Unrelated Donor HCT
[Blood] Researchers conducted a Phase I/II trial evaluating high-dose palifermin for preventing severe chronic GVHD in matched unrelated donor T cell replete peripheral-blood HCT following reduced-intensity conditioning.
Regulation of H3K4me3 Breadth and MYC Expression by the SETD1B Catalytic Domain in MLL-Rearranged Leukemia
[Leukemia] Researchers identified the modifier responsible for high histone H3 lysine 4 trimethylation (H3K4me3) modification in mixed-lineage leukemia-rearranged (MLL-r) leukemia and its downstream targets essential for the cell proliferation.
Phase II Study of Venetoclax Added to Bendamustine and Obinutuzumab in Patients with High-Risk Follicular Lymphoma As Front-Line Therapy: PrE0403
[Blood Cancer Journal] The Phase II PrE0403 study was designed to evaluate intermittent dosing of venetoclax combined with obinutuzumab and bendamustine in untreated follicular lymphoma subjects with high-risk features defined as a FLIPI-1 score of ≥3 and/or high tumor burden by GELF criteria.
Design Principles of Cell-State-Specific Enhancers in Hematopoiesis
[Cell] Investigators characterized 64,400 fully synthetic DNA sequences to bottom-up dissect design principles of cell-state-specific enhancers in the context of the differentiation of blood stem cells to seven myeloid lineages.
Novel, Potent, and Orally Bioavailable LSD1 Inhibitors Induce Fetal Hemoglobin Synthesis in a Sickle Cell Disease Mouse Model
[Blood] Researchers utilized structure-aided drug design to develop potent new reversible lysine-specific demethylase 1 inhibitors' (LSD1i's) leading to robust γ-globin expression in vitro.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
