Celsion Affirms July Timing for Second Interim Analysis of the Phase III OPTIMA Study of ThermoDox® in Primary Liver Cancer

Celsion Corporation have affirmed that the independent data monitoring mommittee is scheduled to meet during the first half of July to conduct the second pre-planned interim safety and efficacy analysis of the Phase III OPTIMA Study with ThermoDox® plus radiofrequency ablation in patients with hepatocellular carcinoma, or primary liver cancer.
[Celsion Corp.]
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Decreased miR-200b-3p in Cancer Cells Leads to Angiogenesis in HCC by Enhancing Endothelial ERG Expression

Researchers investigated whether hepatocyte-derived miR-200b-3p governed angiogenesis in hepatocellular carcinoma (HCC) by targeting endothelial erythroblast transformation-specific-related gene (ERG).
[Scientific Reports]
Moh-Moh-Aung, A., Fujisawa, M., Ito, S., Katayama, H., Ohara, T., Ota, Y., … Matsukawa, A. (2020). Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression. Scientific Reports, 10(1), 10418. https://doi.org/10.1038/s41598-020-67425-4 Cite
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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
[Cancer Research]
Zhang, Y., Cedervall, J., Hamidi, A., Herre, M., Viitaniemi, K., D’Amico, G., … Olsson, A.-K. (2020). Platelet-specific PDGFB ablation impairs tumor vessel integrity and promotes metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-3533 Cite
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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An Endoplasmic Reticulum Stress‐MicroRNA‐26a Feedback Circuit in Nonalcoholic Fatty Liver Disease

Scientists identified a negative feedback loop comprising hepatic endoplasmic reticulum (ER) stress and micro RNA (miRNA)‐26a in nonalcoholic fatty liver disease pathogenesis. Combining miRNA dot blot array and quantitative PCR, they found that miR‐26a was specifically induced by ER stress in liver cells.
[Hepatology]
Xu, H., Tian, Y., Tang, D., Zou, S., Liu, G., Song, J., Zhang, G., Du, X., Huang, W., He, B., Lin, W., Jin, L., Huang, W., Yang, J., & Fu, X. (n.d.). An Endoplasmic Reticulum Stress-MicroRNA-26a Feedback Circuit in Nonalcoholic Fatty Liver Disease. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31428 Cite
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The Role of MDM2–p53 Axis Dysfunction in the Hepatocellular Carcinoma Transformation

The authors focus on the current studies of the MDM2–p53 axis in hepatocellular carcinoma, and specifically discuss the impact of MDM2–p53 axis dysfunction by viral infection and metabolic disease in the transformation of normal hepatocytes into hepatoma cells.
[Cell Death Discovery]
The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation | Cell Death Discovery. (n.d.). Retrieved June 23, 2020, from https://www.nature.com/articles/s41420-020-0287-y Cite
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The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease

Treatment with either of two bone morphogenetic protein (BMP) inhibitors reduced hepatic triglyceride content in diabetic mice. BMP inhibitor-induced decrease in hepatic triglyceride levels was associated with decreased mRNA encoding Dgat2, an enzyme integral to triglyceride synthesis.
[Scientific Reports]
Thayer, T. E., Lino Cardenas, C. L., Martyn, T., Nicholson, C. J., Traeger, L., Wunderer, F., Slocum, C., Sigurslid, H., Shakartzi, H. R., O’Rourke, C., Shelton, G., Buswell, M. D., Barnes, H., Neitzel, L. R., Ledsky, C. D., Li, J. P., Burke, M. F., Farber-Eger, E., Perrien, D. S., … Malhotra, R. (2020). The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease. Scientific Reports, 10(1), 9831. https://doi.org/10.1038/s41598-020-66770-8 Cite
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Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Mutation of the hepatocyte nuclear factor (HNF)-1 binding site significantly decreased the promoter activity in hepatocytes, and the promoter carrying the mutated HNF-1 site was not transactivated by co-transfection of HNF-1 in a non-hepatic cell line.
[Scientific Reports]
Watanabe, T., Ozawa, A., Masuda, S., Yoshino, S., Ishida, E., Kondo, Y., Matsumoto, S., Katano-Toki, A., Horiguchi, K., Nakajima, Y., Yamada, E., Tomaru, T., Saito, T., Ishii, S., Shibusawa, N., Okada, S., Satoh, T., & Yamada, M. (2020). Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver. Scientific Reports, 10(1), 9999. https://doi.org/10.1038/s41598-020-66570-0 Cite
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