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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
GSK to Acquire Efimosfermin, a Phase III-Ready Potential Best-in-Class Specialty Medicine to Treat, and Prevent Progression of Steatotic Liver Disease (SLD)
[GSK Plc.] GSK plc and Boston Pharmaceuticals announced that they have entered into an agreement under which GSK will acquire Boston Pharmaceuticals’ lead asset, efimosfermin alfa.
ECM1 Protects against Liver Steatosis through PCBP1-Mediated Iron Homeostasis
[Hepatology] Hepatic extracellular matrix protein 1 (ECM1) expression was evaluated and found to be significantly reduced in liver samples from patients with metabolic dysfunction-associated steatohepatitis, and in four established MASH mouse models.
GPD1L Supports Glycerol-3-Phosphate and Triacylglycerol Synthesis and Promotes Tumor Progression in Hepatocellular Carcinoma
[Hepatology] Investigators performed transcriptomic analysis on clinical HCC samples from in-house and public cohorts and detected upregulation of glycerol-3-phosphate dehydrogenase 1 like among glycerol phosphate dehydrogenase family genes in HCC.
UFMylation Safeguards Human Hepatocyte Differentiation and Liver Homeostasis by Regulating Ribosome Dissociation
[Cell Reports] Scientists systematically demonstrate the significance of UFMylation in the differentiation and maturation of hepatocytes using hESC-derived hepatocyte-like cells and liver bud organoids as experimental platforms.
Metabolic Dysfunction-Associated Steatotic Liver Disease and Pregnancy
[Journal of Clinical Investigation] Although routine screening for metabolic dysfunction–associated steatotic liver disease has not been established in pregnancy, individuals with metabolic comorbidities, such as type 2 diabetes mellitus, should be evaluated by liver imaging and liver panel.
Bile Acid Accumulation Induced by mir-122 Deficiency in Liver Parenchyma Promotes Cancer Cell Growth in Hepatocellular Carcinoma
[Molecular Therapy-Nucleic Acids] The authors discovered that elevated hepatic bile acids were associated with miR-122 downregulation during liver regeneration, steatosis, and fibrosis.
XPD Regulates MIAT/miR-29a-3p/COL4A1 Axis to Impede Hepatocellular Carcinoma Development
[FASEB Journal] Investigators revealed the underlying mechanism of xeroderma pigmentosum group D (XPD) in HCC. XPD and miR-29a-3p are down-regulated, and MIAT and COL4A1 are up-regulated in tumor tissues of HCC patients.
GPX4 Degradation Contributes to Heat Stress-Induced Liver Injury via Chaperone-Mediated Autophagy
[Biochimica Et Biophysica Acta-Molecular Cell Research] Using mouse and cellular heat stress (HS) models, researchers demonstrated that HS induced liver injury through ferroptosis, as evidenced by increased levels of malondialdehyde, oxidized glutathione, and iron, alongside decreased glutathione and glutathione peroxidase 4 expression.
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
[Advanced Science] An in vitro NAFLD model was developed using chemically defined, engineered hydrogels and hiPSC-derived hepatic organoids.
SFTSV Induces Liver Ferroptosis through m6a-Related Ferritinophagy
[Autophagy] Scientists reported that severe fever with thrombocytopenia syndrome virus (SFTSV) infection perturbed the classical redox cycle by downregulating the expression of GPX4, SLC7A11 and GSH, and increasing the level of reactive oxygen species and malondialdehyde.
Activation of RAS/MEK/ERK Signaling Drives Biliary Differentiation in Primary Liver Cancer
[Gut] Researchers used genetically engineered mouse models with liver-specific deletion of tumour suppressors Rb and p53 together with activation of oncogenic Kras to investigate the cell of origin in intrahepatic cholangiocarcinoma.
Sitravatinib Targets TYRO3 to Augment the Anti-Tumor Immune Response of PD-1 Blockade in Hepatocellular Carcinoma
[Clinical Cancer Research] Scientists investigated the anti-tumor efficacy and immunomodulatory activity of sitravatinib in hepatocellular carcinoma.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
