Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Stem-Like and Effector Peripheral Helper T Cells Comprise Distinct Subsets in Rheumatoid Arthritis
[Science Immunology] Investigators demonstrated that Peripheral helper T (TPH) cells comprise two subsets in thumatoid arthritis: stem-like TPH and effector TPH cells. These two subsets differed in transcriptome, epigenome, B cell helper capacity, spatial localization, and cell interactions.
Combined Flt3L and CD40 Agonism Restores Dendritic Cell-Driven T Cell Immunity in Pancreatic Cancer
[Science Immunology] Scientists found that low tissue expression of Fms-like tyrosine kinase 3 ligand (Flt3L) partially underlies conventional dendritic cell deficits.
Active Antigen-Specific Adaptive Immune Responses Are Shared Among Patients with Progressive Fibrotic Interstitial Lung Disease
[American Journal of Respiratory and Critical Care Medicine] Researchers determined whether immune responses in the lung lymph nodes of interstitial lung disease patients were antigen-specific and significant to pathology and etiology.
Prdm12 Governs an Epigenetic Checkpoint Linking Neuroimmune Cross-Talk to CD8+ T Cell Exhaustion-Suppressed Antitumor Immunity
[Science Advances] Scientists performed an epigenetic-wide CRISPR-Cas9 screen in CD8+ T cells directly under cancer immunotherapy setting and found that Prdm12 is a transcriptional repressor implicated in nociceptive neuron development but uncharacterized within immunological contexts.
Targeting Lipid Scrambling Potentiates Ferroptosis and Triggers Tumor Immune Rejection
[Science Advances] Investigators identified TMEM16F as a ferroptosis suppressor at the executional phase. TMEM16F-deficient cells display heightened sensitivity to ferroptosis.
Neoadjuvant Anti-Programmed Death-1 Immunotherapy by Pembrolizumab in Resectable Non-Small Cell Lung Cancer: Results of the NEOMUN Trial
[Journal for Immunotherapy of Cancer] Two cycles of pembrolizumab were administered before surgery. The primary objectives were to assess the feasibility and safety of neoadjuvant treatment and evaluate antitumor activity. They analyzed the clinical parameters and pathological, radiological, and metabolic tumor response data.
ULBP2 CAR-T Cells Enhance Gastric Cancer Immunotherapy by Inhibiting CAF Activation
[Cell Death & Disease] The authors identified UL16 binding protein 2 (ULBP2) as a potential therapeutic target in gastric cancer (GC). Mechanistically, ULBP2 overexpression activates the TGF-β signalling pathway, promoting the activation of cancer-associated fibroblasts and tumor progression in GC.
m6a-Modified circZNF548 Regulates Exosomal Mir-7108-3p to Activate CD3+CD8+ T Cells and Suppress NSCLC Growth by JMY
[BMC Biology] Researchers investigated the role of N6-methyladenosine (m6A)-modified circZNF548 in the proliferation and migration of non-small cell lung cancer (NSCLC) within the tumor microenvironment.
Mechanism of CD83 Expression Induction through Dectin-1 and β-Glucan Interaction in Innate Immune Responses
[Immunology and Cell Biology] Scientists offer novel insights into the immunoregulatory role of CD83 and its regulatory mechanisms, highlighting potential strategies for treating fungal infections and autoimmune diseases.
Th9-Derived IL-9 in Autoimmune Diseases: An Update
[Life Sciences] Exploring drugs targeting Th9 cells or IL-9 and elucidating the regulatory mechanisms of Th9 and IL-9 in various autoimmune diseases will provide important insights for the development of novel therapeutic strategies.
Sanofi’s Rilzabrutinib Earns Orphan Designation in the EU for IgG4-Related Disease
[Sanofi] The European Medicines Agency (EMA) has granted orphan designation to rilzabrutinib, a reversible covalent Bruton’s tyrosine kinase inhibitor, for IgG4-related disease. EMA grants orphan designation to investigational therapies addressing rare, life-threatening, or debilitating medical diseases or conditions that affect no more than 5 in 10,000 persons in the EU.
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8 Effector T Cells in Acute Myocarditis
[Circulation] Investigators identified that a specialized type of CD8+ effector T cells, CD57+CD8+ T cells with high cytotoxicity and migration potential, were significantly enriched and exhibited large clonal expansion in acute myocarditis.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
