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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Unlocking Novel T Cell-Based Immunotherapy for Hepatocellular Carcinoma through Neoantigen-Driven T Cell Receptor Isolation
[Gut] Investigators evaluated T cell responses in patients with advanced hepatocellular carcinoma by analysing tumours, liver flushes and liver-draining lymph nodes, to understand whether reactive T cell populations could be identified despite the immunosuppressive environment.
NLRP6 Deficiency Enhances Macrophage-Mediated Phagocytosis via E-Syt1 to Inhibit Hepatocellular Carcinoma Progression.
[Gut] Scientists investigated the role of macrophage NOD-like receptor family pyrin domain containing 6 (NLRP6) in hepatocellular carcinoma progression and its therapeutic potential.
The MURANO Study: Final Analysis and Retreatment/Crossover Substudy Results of VenR for Patients with Relapsed/Refractory CLL.
[Blood] Fixed-duration venetoclax-rituximab in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) in the Phase III MURANO trial resulted in superior progression-free survival and overall survival vs bendamustine-rituximab.
IL-10 from Tumoral B Cells Modulates the Diffuse Large B-Cell Lymphoma Microenvironment and Response to Immunotherapy.
[Blood] Researchers showed that IL-10–deficient lymphomas acquire a highly immunosuppressed and T-cell–exhausted microenvironment with increased angiogenesis that results in a more aggressive phenotype, which is refractory to PD-1 immune checkpoint blockade.
A Phase I/II Trial of WT1-Specific TCR Gene Therapy for Patients with Acute Myeloid Leukemia and Active Disease Post-Allogeneic Hematopoietic Cell Transplantation: Skewing Towards...
[Nature Communications] In this Phase I/II clinical trial, scientists evaluated safety, persistence and efficacy of Epstein-Barr virus- or Cytomegalovirus-specific Tumor Antigen 1-specific T-cell receptor in fifteen patients with active acute myeloid leukemia post-hematopoietic cell transplantation.
Combined Dendritic Cell and Anti-TIGIT Immunotherapy Potentiates Adaptive NK Cells against HIV-1.
[EMBO Molecular Medicine] Investigators demonstrated that dendritic cells primed with nanoparticles containing Poly I:C enhanced the natural cytotoxic function of natural killer cells from effective responder people with HIV-1.
Multi-Omics Analyses Reveal Interactions between GREM1+ Fibroblasts and SPP1+ Macrophages in Gastric Cancer.
[NPJ Precision Oncology] Tumor-specific GREM1+ fibroblasts and SPP1+ macrophages were significantly enriched in gastric cancer tissues and were involved in immunosuppression, inflammation regulation, and tumor progression.
Aging-Dependent Change in Th17 and Cytokine Response in Multiple Sclerosis.
[Journal of Neuroinflammation] Investigators examined whether peripheral production of Myelin Basic Protein-driven cytokine responses mediate the aging-associated decline in multiple sclerosis inflammatory disease activity.
Circulating T Cell Atlas in Moyamoya Disease: Insights into Immunopathogenesis of Cerebrovascular Disorders.
[Journal of Neuroinflammation] Researchers highlighted the critical involvement of immune activation and mitochondrial dysfunction in the pathophysiology of moyamoya disease, providing novel insights into disease mechanisms and identifying immunometabolic pathways as potential targets for therapeutic intervention.
Artemisinins in Autoimmune Diseases: Effects and Mechanisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis.
[British Journal of Pharmacology] Scientists examined artemisinin's application in systemic lupus erthematosus and rheumatoid arthritis, emphasizing its therapeutic potential and mechanism insights.
Apellis and Sobi Announce EMPAVELI® (Pegcetacoplan) Showed Sustained Efficacy at One Year in Phase III Study for C3G and Primary IC-MPGN
[Apellis Pharmaceuticals, Inc.] Apellis Pharmaceuticals, Inc. presented new data from the open-label period of the Phase III VALIANT study, investigating EMPAVELI® for C3 glomerulopathy and primary immune complex membranoproliferative glomerulonephritis.
MindImmune Awarded Grant to Accelerate IND-Enabling Studies through Rhode Island Life Science Hub
[MindImmune Therapeutics (PR Newswire)] MindImmune Therapeutics announced it has been awarded a grant by Rhode Island Life Science Hub to accelerate the company’s preclinical development work on MITI-101. MITI-101 is under development for the treatment of mild-to-moderate Alzheimer’s disease.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
