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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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DDX17 and Viral Infection
[Virulence] The authors uncover the unique roles of DEAD-box RNA helicase 17 (DDX17) in diverse viral infections through a comprehensive review of existing studies and explores its prospects as a therapeutic target for antiviral interventions.
Houston Methodist Partners with CEPI and International Scientific Institutions to Advance First AI-Designed mRNA Vaccine against Deadly Tick-Borne Disease
[Houston Methodist Research Institute] Houston Methodist Research Institute is collaborating with the Coalition for Epidemic Preparedness Innovations and leading scientific institutions in the Republic of Korea to develop what could become the world’s first mRNA vaccine against severe fever with thrombocytopenia syndrome, a tick-borne viral disease associated with this condition.
Harnessing Virus-Specific T Cells: Expanding Therapeutic Strategies across Diverse Populations
[Blood Advances] Scientists explore the manufacturing, feasibility, safety, and efficacy of virus-specific T cells (VST). They examine recent advancements in VST manufacturing that broaden their accessibility and applicability to a wider range of viral infections and immunocompromised populations.
Early Skin Seeding Regulatory T Cells Modulate PPARγ-dependent Skin Pigmentation
[Nature Communications] The authors showed that skin Tregs are detected as early as postnatal day three and enter a dynamic flux of activation marker expression.
CytoMed Therapeutics Announces Novel First-In-Human Clinical Trial Collaborations with Renowned and Prestigious Hospital Partner to Advance Its Off-The-Shelf Donor-Derived Gamma Delta T Cells Allogeneic...
[CytoMed Therapeutics, Limited. (GlobeNewswire)] CytoMed Therapeutics, Ltd. announced that it has entered into a Memorandum of Understanding with Universiti Malaya Medical Centre to establish a multi-site, first-in-human Phase I clinical trial to investigate the safety and efficacy of CytoMed’s patented allogeneic unmodified Gamma Delta T cells for cancer patients in Malaysia.
Pew Funds 7 New Biomedical Research Collaborations
[The Pew Charitable Trusts] The Pew Charitable Trusts announced today the seven pairs of researchers who will make up its 2025 class of Innovation Fund investigators. These 14 acclaimed scientists will collaborate on interdisciplinary research projects bringing together their expertise in such specialties as neuroscience, immunology, and cancer biology.
DC Subsets and States Unraveled across Human Juxtatumoral and Malignant Tissues
[Nature Immunology] Scientists integrated dendritic cells (DC) from 13 tumor tissues across 40 datasets to create a plasmacytoid DC + myeloid DC (mDC)-VERSE and an mDC-VERSE single-cell RNA-sequencing compendium. They characterized DC subsets and ‘states’ across these tissues.
3D Chromatin-Based Variant-to-Gene Maps across 57 Human Cell Types Reveal the Cellular and Genetic Architecture of Autoimmune Disease Susceptibility
[Genome Biology] Investigators pharmacologically validated squalene synthase implicated by their approach and supported by prior eQTL data in multiple sclerosis and systemic lupus erythematosus, as a novel immunomodulatory drug target controlling T cell inflammatory cytokine production and aiding B cell antibody production in a human lymphoid organoid model.
Galectin-9 Binding to HLA-DR in Dendritic Cells Controls Immune Synapse Formation and T Cell Proliferation
[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported galectin-9-mediated HLA-DR organization at the dendritic cell synapse, uncovering a mechanism through which intracellular galectins coordinate immune receptor positioning to enhance CD4+ T cell activation.
Maternal Diet Shapes the Development and Identity of Tissue-Resident Macrophages
[Trends in Immunology] The authors summarize how specific maternal diets program distinct tissue-resident macrophage (TRMs) subsets and how programmed TRMs link maternal nutritional statuses to disease susceptibility.
Macrophage MR1 Antigen Presentation Promotes MAIT Cell Immunity and Lung Microbiota Modulation
[Science] Depletion of MHC class I-related protein 1 (MR1) in macrophages, dendritic cells, and monocytes changed the composition of the microbiota and impaired mucosal associated invariant T (MAIT) cell responses against bacterial infection.
Immune Cells Dying from Ferroptosis: Mechanisms and Therapeutic Opportunities
[Cell Death & Disease] The authors summarize the therapeutic potential of targeting ferroptosis pathways in tumor immunity, pathogen infections, inflammation, and autoimmune diseases.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
