Category Archives: Human Immunology

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel

Serum cytokine and catecholamine levels were measured prior to lymphodepleting chemotherapy, on the day of CAR T infusion and daily thereafter while patients remained hospitalized.
[Clinical Cancer Research]
Faramand, R. G., Jain, M. D., Staedtke, V., Kotani, H., Bai, R.-Y., Reid, K., … Davila, M. L. (2020). Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1434 Cite
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AC Immune Advances phospho-Tau Alzheimer’s Vaccine in Phase Ib/IIa Study

AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease.
[AC Immune]
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Open-Access Plan S to Allow Publishing in Any Journal

Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
[Nature News]
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Resistance to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Biomarkers and Therapeutic Strategies

The authors highlight the absence of a common definition of primary and secondary resistance and summarize their frequency and clinical characteristics.
[Therapeutic Advances in Medical Oncology]
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Quantitative Investigation into the Influence of Intravenous Fluids on Human Immune and Cancer Cell Lines

The effect of intravenous fluids exposure on single cells was characterized using hemocytometer, fluorescence microscopy and flow cytometry
[Scientific Reports]
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A New Dawn for Eosinophils in the Tumor Microenvironment

Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.
[Nature Reviews Cancer]
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During the Pandemic, Students Do Field and Lab Work without Leaving Home

Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
[Science Insider]
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Tumor Response and Endogenous Immune Reactivity after Administration of HER2 CAR T Cells in a Child with Metastatic Rhabdomyosarcoma

Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins.
[Nature Communications]
Hegde, M., Joseph, S. K., Pashankar, F., DeRenzo, C., Sanber, K., Navai, S., … Ahmed, N. (2020). Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nature Communications, 11(1), 3549. https://doi.org/10.1038/s41467-020-17175-8 Cite
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An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity

Scientists developed a highly multiplexed screen to quantify the co-expression of 351 surface molecules on millions of human B cells.
[Immunity]
Glass, D. R., Tsai, A. G., Oliveria, J. P., Hartmann, F. J., Kimmey, S. C., Calderon, A. A., … Bendall, S. C. (2020). An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity. Immunity, 53(1), 217-232.e5. https://doi.org/10.1016/j.immuni.2020.06.013 Cite
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An Analysis of Ways to Decarbonize Conference Travel after COVID-19

The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
[Nature News]
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Foreign Students in US: Trump Administration Drops Deportation Plans

US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC]
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