Serum cytokine and catecholamine levels were measured prior to lymphodepleting chemotherapy, on the day of CAR T infusion and daily thereafter while patients remained hospitalized.
[Clinical Cancer Research]
6445212 CF9SM8VT items 1 apa default asc 1
Faramand, R. G., Jain, M. D., Staedtke, V., Kotani, H., Bai, R.-Y., Reid, K., … Davila, M. L. (2020). Tumor Microenvironment composition and severe cytokine release syndrome (CRS) Influence Toxicity in Patients with Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-1434 Cite
AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease.
Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
The authors highlight the absence of a common definition of primary and secondary resistance and summarize their frequency and clinical characteristics.
[Therapeutic Advances in Medical Oncology]
The effect of intravenous fluids exposure on single cells was characterized using hemocytometer, fluorescence microscopy and flow cytometry
Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.
[Nature Reviews Cancer]
Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins.
6445212 JC6XRD98 items 1 apa default asc 1
Hegde, M., Joseph, S. K., Pashankar, F., DeRenzo, C., Sanber, K., Navai, S., … Ahmed, N. (2020). Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nature Communications, 11(1), 3549. https://doi.org/10.1038/s41467-020-17175-8 Cite
Scientists developed a highly multiplexed screen to quantify the co-expression of 351 surface molecules on millions of human B cells.
6445212 AM8XHNMJ items 1 apa default asc 1
The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.