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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Trump Administration Ends Program Critical to Search for an H.I.V. Vaccine
The Trump administration has dealt a sharp blow to work on H.I.V. vaccines, terminating a $258 million program whose work was instrumental to the...
TSC22 Domain Family Member 3 Links Natural Killer Cells to CD8+T Cell-Mediated Drug Hypersensitivity
[Signal Transduction and Targeted Therapy] Scientists highlighted the importance of natural killer cell heterogeneity and TSC22D3 in immune-mediated hypersensitivity disorders, offering potential therapeutic targets for severe cutaneous adverse drug reactions and related conditions.
Enhanced Nano-Vaccine Utilizing Biomineralized Virus-Like Particles for Efficient Glioblastoma Immunotherapy via the Nose-to-Brain Delivery Pathway
[ACS nano] Researchers developed a calcium phosphate (CaP)-covered nanovaccine (NV) based on hepatitis B core antigen derived virus-like particles (HBc VLPs), optimized for mucosal delivery applications.
Magnetic Microcarrier-Based Whole Tumor Cell Vaccines for Tumor Prevention and Immunotherapy
[ACS Nano] This gelatin microcarrier-based vaccine, combined with localized alternating magnetic field-induced hyperthermia, effectively promotes dendritic cell recruitment, enhances immune responses, and effectively inhibits tumor growth.
Effects of Triclosan on Cytokine Production by Human Immune Cells In Vitro
[Environment International] Researchers characterized the effect of triclosan on cytokine responses of peripheral blood mononuclear cells.
Tumor-Specific MHC-II Activates CD4+ and CD8+ T Cells in Head and Neck Squamous Cell Carcinoma to Boost Immunotherapy Efficacy
[Cancer Research] Investigators integrated single-cell RNA-sequencing and T cell receptor-sequencing to comprehensively characterize the tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma biopsies prior to a Phase II neoadjuvant immunotherapy clinical trial.
Ultrasonic Cavitation-Manipulated Macrophages Hitchhiking Augments Delivery of Nanocarriers for Active and Efficient Cancer Therapy
[Advanced Healthcare Materials] Scientists presented a promising strategy for efficient cancer therapy by utilizing ultrasound-regulated nanodrug-hitchhiking macrophages.
Pentose Phosphate Pathway Inhibition Metabolically Reprograms CD8+ T Cells and Disrupts CNS Autoimmunity
[JCI insight] Inhibiting the pentose phosphate pathway disrupts CD8+ T cell metabolic reprogramming and effector functions, suggesting that such inhibition may serve as a therapeutic strategy to prevent neurodegeneration in patients with progressive multiple sclerosis.
Different Rheumatoid Factor Binding Patterns Distinguish between SjöGren’S Disease with or without Associated RA
[RMD Open] Both IgM-rheumatoid factors (RF) and IgA-RF profiles of Sjögren’s disease-rheumatoid arthritis (SjD-RA) patients closely resembled those of RA patients and were distinctly different from those found among SjD patients.
Prediction of Thrombotic Events in Patients with Autoimmune Hemolytic Anemia: A Multicenter Retrospective Observational Study
[Journal of Thrombosis and Thrombolysis] This retrospective multicenter observational study assessed thrombotic event incidences, identified associated thrombotic risk factors, and assessed the external validity of the Padua score in autoimmune hemolytic anemia for predicting venous thromboembolism.
Wnt/β-Catenin Mediated Signaling Pathways in Cancer: Recent Advances, and Applications in Cancer Therapy
[Molecular Cancer] The authors provide a comprehensive analysis of current understanding regarding the Wnt/β-catenin pathway in malignancy, emphasizing its multifaceted roles in tumor initiation, therapeutic resistance, and immune regulation.
Sana Biotechnology Announces Positive Six-Month Clinical Results from Type 1 Diabetes Study of Islet Cell Transplantation without Immunosuppression
[Sana Biotechnology, Inc] Sana Biotechnology, Inc. announced six-month follow-up results from an investigator-sponsored, first-in-human study transplanting UP421, an allogeneic primary islet cell therapy engineered with Sana’s hypoimmune technology, into a patient with type 1 diabetes without any immunosuppression.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
