Dissecting Intratumour Heterogeneity of Nodal B-Cell Lymphomas at the Transcriptional, Genetic and Drug-Response Levels

Researchers identified transcriptionally distinct malignant subpopulations and compared their drug-response and genomic profiles. Malignant subpopulations from the same patient responded strikingly differently to anti-cancer drugs ex vivo, which recapitulated subpopulation-specific drug sensitivity during in vivo treatment.
[Nature Cell Biology]
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Inosine Is an Alternative Carbon Source for CD8+-T-Cell Function under Glucose Restriction

Scientists showed that effector T cells could utilize inosine, as an alternative substrate, to support cell growth and function in the absence of glucose in vitro. T cells metabolized inosine into hypoxanthine and phosphorylated ribose by purine nucleoside phosphorylase.
[Nature Metabolism]
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A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.
[Bone Research]
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Intragenic Recruitment of NF-κB Drives Splicing Modifications upon Activation by the Oncogene Tax of HTLV-1

Investigators demonstrated that recruitment of the NF-κB factor RELA to intragenic regions regulated alternative splicing upon NF-κB activation by the viral oncogene tax of HTLV-1.
[Nature Communications]
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Neutrophils Preferentially Phagocytose Elongated Particles—An Opportunity for Selective Targeting in Acute Inflammatory Diseases

Scientists investigated the phagocytosis of rod-shaped polymeric particles by human neutrophils relative to other leukocytes. In contrast to macrophages and other mononuclear phagocytes, neutrophils were found to exhibit increased internalization of rods in ex vivo and in vivo experimentation.
[Science Advances]
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CD56 Regulates Human NK Cell Cytotoxicity through Pyk2

Investigators demonstrated that deletion of CD56 on the NK92 cell line led to impaired cytotoxic function. CD56-knockout cells failed to polarize during immunological synapse formation and have severely impaired exocytosis of lytic granules.
[eLife]
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Essential Contribution of Macrophage Tie2 Signaling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientists observed that Tie2-expressing macrophages prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase and v-akt murine thymoma viral oncogene-dependent signaling pathways.
[Scientific Reports]
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Phase I Trial of Expanded, Activated Autologous NK Cell Infusions with Trastuzumab in Patients with HER2-Positive Cancers

The authors infused expanded, activated autologous natural killer cells to potentiate trastuzumab-mediated antibody-dependent cell cytotoxicity in patients with HER2-positive malignancies.
[Gene Therapy]
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City of Hope Signs Licensing Agreement with Scopus BioPharma Inc. to Develop Novel, Targeted Immuno-Oncology Gene Therapy

City of Hope have signed an exclusive, worldwide licensing agreement with Scopus BioPharma Inc. Scopus will further develop and plans to commercialize a City of Hope first-in-class, targeted immuno-oncology gene therapy.
[City of Hope]
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Role of DNA-LL37 Complexes in the Activation of Plasmacytoid Dendritic Cells and Monocytes in Subjects with Type 1 Diabetes

Following in vitro stimulation with DNA-LL37 complexes, type 1 diabetes group demonstrated higher frequency and mean fluorescence intensity of plasmacytoid dendritic cells expressing IFN-α.
[Scientific Reports]
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