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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
CD200R Activation on Naïve T Cells by B Cells Induces Suppressive Activity of T Cells via IL-24
[Cellular and Molecular Life Sciences] The authors investigated the role of CD200 in Treg-of-B (P) cell generation. They revealed that Peyer’s patch B cells expressed CD200 to activate the CD200R on T cells and initiated the process of Treg-of-B (P) cell generation.
The Integration of Metabolic and Proteomic Data Uncovers an Augmentation of the Sphingolipid Biosynthesis Pathway During T-Cell Differentiation
[Communications Biology] Scientists found that the sphingolipid biosynthesis pathway was commonly activated in Th1, Th2, Th17, and iTreg cells and that inhibition of this pathway led to the suppression of Th17 and iTreg cells differentiation.
High Common-γ Cytokine Receptor Levels Promote Expression of Interleukin-2/Interleukin-7 Receptor α-Chains With Implications on T-Cell Differentiation and Function
[Immunology] Researchers studied the influence of differential common-γ receptor chain (γc) expression on the expression of the IL-2Rα, the IL-7Rα, and the differentiation of activated naïve T cells. They fine-tuned the regulation of γc expression in human primary naïve T cells by lentiviral transduction using small hairpin (sh)RNAs and γc cDNA.
Treg-Derived TGF-β1 Dampens cGAS-STING Signaling to Downregulate the Expression of Class I MHC Complex in Multiple Myeloma
[Scientific Reports] To investigate Treg's influence on multiple myeloma (MM) cells, researchers established a co-culture system using Tregs from MM patients and the MM cell lines in vitro and assessed the effects of intervening in the relevant pathways connecting Tregs and MM cells in vivo.
Combination of Proton- or X-Irradiation with Anti-PDL1 Immunotherapy in Two Murine Oral Cancers
[Scientific Reports] Scientists compared responses for two syngeneic head and neck cancer tumor models in mice following X-ray or proton irradiation with or without immune checkpoint inhibition.
Foxo3 Regulates Cortical and Medullary Thymic Epithelial Cell Homeostasis With Implications in T Cell Development
[Cell Death & Disease] Researchers showed that mice with thymic epithelial cells (TEC)-specific deletion of Foxo3 displayed a disrupted medullary TEC (mTEC) compartment, with a more profound impact on the numbers of CCL21+ and thymic tuft mTEClo subsets.
PKC-θ Is an Important Driver of Fluoride-Induced Immune Imbalance of Regulatory T Cells/Effector T Cells
Scientists explored the mechanism of fluoride interference in the immune system and also identify the key indicators of fluoride-induced immune damage.
[Human Reproduction] AbstractGraphical Abstract
Bevacizumab Induces Ferroptosis and Enhances CD8+ T Cell Immune Activity in Liver Cancer via Modulating HAT1 and Increasing IL-9
Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line...
Genetic Polymorphisms in IL-2, IL-10 and FOXP3 Are Associated with Autoimmune Neutropaenia in Early Childhood and Autoantibody Specificity in a Danish Cohort
[Scandinavian Journal Of Immunology] The association between regulatory T cells and autoimmune neutropaenia has been described, and in this study, researchers investigated three Treg-associated genes, IL-2, IL-10, and FOXP3.
Increased Frequencies of Highly Activated Regulatory T Cells Skewed to a T Helper 1-Like Phenotype With Reduced Suppressive Capacity in Dengue Patients
[mBio] Scientists defined in detail the phenotype and function of different regulatory T cell subsets and their association with disease severity in a cohort of acute dengue virus -infected Cambodian children.
Low Serum Apolipoprotein A1 Impairs Antitumor Immunity of CD8+ T Cells via the HIF-1α–Glycolysis Pathway
[Cancer Immunology Research] CD8+ T cell depletion experiments confirmed that ApoA1 exerted its antitumor activity in a CD8+ T cell–dependent manner. In vitro experiments showed that the ApoA1 mimetic peptide L-4F directly potentiated the antitumor activity of CD8+ T cells via a HIF-1α–mediated glycolysis pathway.
Ganoderma lucidum Spores-Derived Particulate β-Glucan Treatment Improves Antitumor Response by Regulating Myeloid-Derived Suppressor Cells in Triple-Negative Breast Cancer
[International Journal Of Biological Macromolecules] Gemcitabine treatment alone altered the tumor microenvironment, including a reduction in antitumor T cells and a rise in myeloid-derived suppressor cells and regulatory T cells.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
