Treg-Derived TGF-β1 Dampens cGAS-STING Signaling to Downregulate the Expression of Class I MHC Complex in Multiple Myeloma

To investigate Treg’s influence on multiple myeloma (MM) cells, researchers established a co-culture system using Tregs from MM patients and the MM cell lines in vitro and assessed the effects of intervening in the relevant pathways connecting Tregs and MM cells in vivo.