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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
The Effect of COVID-19 Vaccination on Outpatient Antibiotic Prescribing in Older Adults: A Self-Controlled Risk-Interval Study
[Clinical Infectious Diseases] Researchers assessed the impact of COVID-19 vaccination on outpatient antibiotic prescribing in the broader population of older adults, regardless of SARS-CoV-2 infection status.
Integrating Population and Single-Cell Variations in Vaccine Responses Identifies a Naturally Adjuvanted Human Immune Setpoint
[Immunity] Investigators introduce a framework to integrate variations at the human population and single-cell levels in vaccination responses.
Combination of S1–N–Terminal and S1–C–Terminal Domain Antigens Targeting Double Receptor-Binding Domains Bolsters Protective Immunity of a Nanoparticle Vaccine Against Porcine Epidemic Diarrhea Virus
[ACS Nano] Three different types of self-assembled nanoparticles targeting receptor-binding N-terminal domain (NTD) and C-terminal domain (CTD) of S1 protein, named NTDnps, CTDnps, and NTD/CTDnps, were constructed and evaluated as vaccine candidates against PEDV.
Lysosomal Dysfunction by Inactivation of V-ATPase Drives Innate Immune Response in C. elegans
[Cell Reports] The authors discovered that dysfunction of lysosomes caused by inactivation of V-ATPase enhances innate immunity against bacterial infections.
An HLA-E-Targeted TCR Bispecific Molecule Redirects T Cell Immunity Against Mycobacterium tuberculosis
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators described a T cell receptor-based bispecific molecule that potently and selectively bound human leukocyte antigen-E in complex with a peptide encoded by the inhA gene of Mycobacterium tuberculosis, the causative agent of tuberculosis in humans.
Immunoinformatics Design of a Structural Proteins Driven Multi-Epitope Candidate Vaccine Against Different SARS-CoV-2 Variants Based on Fynomer
[Scientific Reports] To design the vaccine, a library of peptides from the spike, nucleocapsid, membrane, and envelope structural proteins of various strains was prepared. Then, the final vaccine structure was optimized using the fully protected epitopes and the fynomer scaffold.
Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019
[Clinical Infectious Diseases] COVID-OUT was a 2 × 3 randomized, placebo-controlled, double-blind trial that assessed metformin, fluvoxamine, and ivermectin; 999 participants self-collected anterior nasal swabs on day 1, day 5, and day 10.
Therapeutic Vaccines for Herpesviruses
[Journal Of Clinical Investigation] The authors summarize the status of therapeutic vaccines for herpes simplex virus, cytomegalovirus, and Epstein-Barr virus and proposes approaches for future development.
Dynamic Diversity of SARS-CoV-2 Genetic Mutations in a Lung Transplantation Patient With Persistent COVID-19
[Nature Communications] Researchers described the clinical case of an immunosuppressed host in whom inadequate treatment resulted in highly diverse SARS-CoV-2 mutations that threatened the patient’s health due to the development of drug-resistant variants.
CD8+ T Cell Responses Towards Conserved Influenza B Virus Epitopes Across Anatomical Sites and Age
[Nature Communications] Scientists increased the number of influenza B viruses (IBV) CD8+ T cell epitopes, and defined IBV-specific CD8+ T cells at cellular and molecular levels, across tissues and age.
Nasal Vaccination of Triple-RBD Scaffold Protein With Flagellin Elicits Long-Term Protection Against SARS-CoV-2 Variants Including JN.1
[Signal Transduction And Targeted Therapy] Scientists investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC) adjuvanted with a flagellin protein.
Cervical Microbiota Dysbiosis Associated With High-Risk Human Papillomavirus Infection
[PLOS One] Investigators highlighted the distinctive roles of L. mucosae and L. helveticus in high-risk human papillomavirus infections, signaling a need for further research to demonstrate the potential clinical implications of cervical microbiota dysbiosis.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
