Nasal Vaccination of Triple-RBD Scaffold Protein With Flagellin Elicits Long-Term Protection Against SARS-CoV-2 Variants Including JN.1

Scientists investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain (RBD) scaffold protein (3R-NC) adjuvanted with a flagellin protein.