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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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HIV-1 Vpr Induces an NFAT-Controlled Transcriptional Program in Primary CD4+ T Cells
[Mbio] Researchers performed RNA sequencing and transcription factor network analyses of primary CD4+ T cells infected with HIV-1 harboring an intact or defective vpr open reading frame.
SIRT4 Regulates Antiviral and Autoimmune Responses by Promoting cGAS-Mediated Signaling Pathways
[EMBO Reports] The authors discovered that SIRT4 is a critical positive regulator of antiviral innate immune responses against DNA viruses and cytosolic DNA.
Interaction Between HIV-1 Tat and EBV Zta Favours Immune Escape of B Cells by Downregulating HLA-ABC Expression
[Cellular and Molecular Life Sciences] Researchers investigated the involvement of human immunodeficiency virus (HIV) 1 and epstein-barr virus co-existence in the development of B cell malignancies.
Inducible CD147 Up-Regulation Boosts Extended SARS-CoV-2 Infection Triggering Severe COVID-19 Independent of ACE2
[Signal Transduction and Targeted Therapy] Researchers found that SARS-CoV-2 infection boosts CD147 inducible up-regulation in the lung tissues of virus-infected rhesus macaques coupled with down-regulated membrane-bound ACE2, which conduces to extended virus infection and severe pathological lesions.
Inhibitory NK Receptor Expression Associates with Altered Antimalarial Function of γδ T Cells
[PLoS Pathogens] Scientists explored phenotypic and functional differences of γδ T cells in Ugandan children with high versus low malaria exposure.
YL1004 Is a SARS-CoV-2 Papain-Like Protease Inhibitor with Immunomodulatory and Antiviral Activity in Mice
[Nature Communications] Researchers presented the rational design and characterization of YL1004, a tricyclic oral PLpro inhibitor demonstrating robust, cross-variant SARS-CoV-2 antiviral activity and favorable pharmacokinetic properties.
Mast Cells Promote Pathology and Susceptibility in Tuberculosis
[eLife] Researchers showed that the distribution and localization of mast cells in pulmonary tuberculosis in humans and macaques were associated with chymase production.
RSV Temporally Reprograms Apoptosis and Pyroptosis to Balance Immune Evasion and Replication
[Science Advances] Scientists demonstrate that respiratory syncytial virus (RSV) orchestrates the temporal and sequential regulation of distinct programmed cell death pathways in human macrophages to optimize replication and dissemination.
Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis Within Tuberculous Granulomas
[Science Advances] Using pharmacological and genetic interventions, researchers found that neutrophils within mature, necrotic granulomas promote bacterial growth, in part through up-regulation of the bacterial devR regulon.
Broad Cross-T Cell Immunity Between Emerging SARS-CoV-2 Serotypes Waved by Spike-Signature Mutations
[Emerging Microbes & Infections] Investigators evaluated SARS-CoV-2 spike-specific T cell responses among convalescents infected by three different strains against SARS-CoV-2 prototype and 15 subvariants covering all six serotypes.
Four Penn Studies Named among Nation’s Top Clinical Research Advances
[Penn Medicine] Perelman School of Medicine papers win Clinical Research Forum’s 2026 Top 10 Clinical Research Achievement Awards, highlighting the power of federal funding for science.
Faecalibacterium Prausnitzii Induces an Anti-Inflammatory Response and a Metabolic Reprogramming in Human Monocytes
[Gastroenterology] Researchers found that F prausnitzii induces an anti-inflammatory response and rewires energy metabolism in human monocytes in healthy and inflamed conditions.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
