Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

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Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis Within Tuberculous Granulomas

January 23, 2026

[Science Advances] Using pharmacological and genetic interventions, researchers found that neutrophils within mature, necrotic granulomas promote bacterial growth, in part through up-regulation of the bacterial devR regulon.

Broad Cross-T Cell Immunity Between Emerging SARS-CoV-2 Serotypes Waved by Spike-Signature Mutations

January 23, 2026

[Emerging Microbes & Infections] Investigators evaluated SARS-CoV-2 spike-specific T cell responses among convalescents infected by three different strains against SARS-CoV-2 prototype and 15 subvariants covering all six serotypes.

Four Penn Studies Named among Nation’s Top Clinical Research Advances

January 23, 2026

[Penn Medicine] Perelman School of Medicine papers win Clinical Research Forum’s 2026 Top 10 Clinical Research Achievement Awards, highlighting the power of federal funding for science.

Faecalibacterium Prausnitzii Induces an Anti-Inflammatory Response and a Metabolic Reprogramming in Human Monocytes

January 23, 2026

[Gastroenterology] Researchers found that F prausnitzii induces an anti-inflammatory response and rewires energy metabolism in human monocytes in healthy and inflamed conditions.

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy

January 23, 2026

[JAMANeurology] In this cohort study of 111 patients with progressive multifocal leukoencephalopathy treated with immune checkpoint inhibitors, those with detectable virus-specific T cells had significantly higher response rates and longer survival than both T cell–negative patients and those with unknown status.

Plasmin Modulates Neutrophilic Inflammation and Alveolar Macrophage Function, Protecting Mice from Pneumococcal Pneumonia

January 23, 2026

[Blood] Scientists investigated the role of Plasminogen/Plasmin on key features of inflammation resolution in a murine model of severe pneumococcal pneumonia.

A Viral Glycoprotein Targets IgG Memory B Cells to Mediate Humoral Immune Evasion

January 23, 2026

[EMBO Molecular Medicine] Scientists reported that the human cytomegalovirus Fcγ-binding glycoprotein 34 modulates humoral immunity by binding to IgG⁺ memory B cells.

Fibroblastic Reticular Cells Direct the Initiation of T Cell Responses via CD44

January 21, 2026

[Nature] Researchers showed that the viral protein m11, encoded by the herpesvirus murine cytomegalovirus, inhibits antiviral immunity by targeting the fibroblastic reticular cell network and interfering with a critical function of cellular CD44. `

Tick-Borne Viruses: Discovery, Clinical Aspects, Influencing Factors, and Control

January 20, 2026

[Nature Reviews Microbiology] The authors summarize tick virome diversity, outline the growing threat of tick-borne viruses (TBV) to humans and animals, and describe the clinical features of TBV infections in humans.

Multi-Antigen DNA Vaccine Targeting Non-Structural Proteins Confers Robust T Cell-Mediated Protection against Zika Virus

January 20, 2026

[NPJ Vaccines] Using immunocompetent mice, scientists performed high-resolution in vivo mapping of ZIKV specific CD8⁺ and CD4⁺ T cell responses following ZIKVPRVABC59 infection, identifying high avidity, polyfunctional memory T cells targeting conserved non-structural (NS) 1, NS3 and NS4 proteins.

Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections

January 20, 2026

[Genes & Immunity] The authors examine studies published over the past five years, focusing on miRNAs involved in immune regulation during four major viral infections: severe acute respiratory syndrome coronavirus 2, hepatitis B virus, human immunodeficiency virus, and herpes simplex virus

Differential Innate Immune Activation by Wild-Type and NSs-Deficient RVFV Strains in Human Blood Monocytes

January 16, 2026

[Emerging Microbes & Infections] Researchers hypothesized that primary infection of circulating immune cells and their response to infection are critical factors determining systemic Rift Valley fever virus (RVFV) spread and pathogenesis.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.