Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

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Human Herpesvirus Evasion of Humoral Immunity and Implications for Vaccine Development

March 13, 2026

[Nature Reviews Microbiology] The authors explore the mechanisms of humoral immune evasion by herpesviruses and their implications for advancing immunization and treatment strategies for chronic neurological, oncological and transplant-associated diseases caused by these common viral pathogens.

Centauri Therapeutics Granted FDA QIDP Status for CTX-187 Treatment of Gram-Negative Bacterial Infections

March 11, 2026

[Centauri Therapeutics Limited] Centauri Therapeutics Limited announced that the Company’s lead clinical candidate in the ABX-01 programme, CTX-187, has received Qualified Infectious Disease Product designation from the US FDA.

First Subjects Dosed in Cocrystal Pharma’s Phase Ib Study Evaluating CDI-988 for Norovirus Prevention and Treatment

March 11, 2026

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. announced the first subjects have been dosed in a Phase Ib norovirus challenge study to evaluate CDI-988, a direct-acting, oral antiviral, as both a preventive and treatment for norovirus infections.

B Cell Imprinting in Children Impairs Antibodies to the Haemagglutinin Stalk

March 11, 2026

[Nature] To understand the basis and impact of imprinting by influenza A viruses, scientists characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza.

From Antibiotic to Peptide Siderophore Conjugates As Modular Strategies against Multidrug-Resistant Bacteria

March 11, 2026

[Clinical Microbiology Reviews] Scientists examine the translational viability of peptide-based antimicrobials and siderophore conjugates—two classes of therapeutics often promoted as next-generation solutions against multidrug-resistant pathogens.

Spike Destabilization Attenuates Mink Cluster 5 SARS-CoV-2

March 11, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Scientists revealed a critical role for an S2 mutation in destabilizing the spike and attenuated phenotypes of the Mink Cluster 5 SARS-CoV-2 variant in humans.

Glucocorticoids Suppress Early Lung Inflammation and Impair Control of SARS-CoV-2 in Non-Human Primates

March 11, 2026

[PLOS One] Researchers used the rhesus macaque model of acute SARS-CoV-2 infection to investigate the impact of glucocorticoids on host responses and viral control in a setting of mild disease.

Controlled Human Helminth Infection Models: Insights into Type 2 Immunity and Therapeutic Development

March 11, 2026

[Trends In Parasitology] Helminths have been tested as inflammatory disease therapeutics. The authors focus on immune responses during controlled infections with Trichuris species, Necator americanus, and Schistosoma mansoni.

Thromboxane Receptor Activation in Dendritic Cells Mitigates Sepsis by Suppressing S100a8/A9-Mediated Neutrophil Recruitment

March 5, 2026

[Signal Transduction and Targeted Therapy] Researchers identified a significant negative correlation between dendritic cell depletion and disease severity in patients with sepsis.

A Single Mutation in Nonstructural Protein 1 Is Critical for the Adaptive Evolution of Influenza B Virus

March 5, 2026

[Nature Communications] Scientists showed that recent Influenza B virus strains exhibit an enhanced ability to evade the innate immune response and an increased replication efficiency compared with earlier strains.

Prolonged Dysregulation and Pathological Changes in the Upper Respiratory Tract of SARS-CoV-2 Infected Hamsters

March 5, 2026

[npj Viruses] The authors characterized persistent upper respiratory tract pathology in SARS-CoV-2-infected hamsters.

Modulation of Immune Cells and Metabolic Reprogramming in Efferocytosis

March 5, 2026

[Cell Death & Disease] The authors discuss the impact of efferocytosis on immune cells during homeostasis and infectious diseases, and in the metabolic reprogramming on phagocyte activation.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.