Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

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Thromboxane Receptor Activation in Dendritic Cells Mitigates Sepsis by Suppressing S100a8/A9-Mediated Neutrophil Recruitment

March 5, 2026

[Signal Transduction and Targeted Therapy] Researchers identified a significant negative correlation between dendritic cell depletion and disease severity in patients with sepsis.

A Single Mutation in Nonstructural Protein 1 Is Critical for the Adaptive Evolution of Influenza B Virus

March 5, 2026

[Nature Communications] Scientists showed that recent Influenza B virus strains exhibit an enhanced ability to evade the innate immune response and an increased replication efficiency compared with earlier strains.

Prolonged Dysregulation and Pathological Changes in the Upper Respiratory Tract of SARS-CoV-2 Infected Hamsters

March 5, 2026

[npj Viruses] The authors characterized persistent upper respiratory tract pathology in SARS-CoV-2-infected hamsters.

Modulation of Immune Cells and Metabolic Reprogramming in Efferocytosis

March 5, 2026

[Cell Death & Disease] The authors discuss the impact of efferocytosis on immune cells during homeostasis and infectious diseases, and in the metabolic reprogramming on phagocyte activation.

Lipid Asymmetry Disruption by XKR8 Orchestrates Neutrophil Extracellular Trap Formation and Inhibits Fungal Infection

March 5, 2026

[Nature Immunology] Researchers identified Xk-related protein 8 (XKR8), a plasma membrane phospholipid scramblase, as a pivotal regulator of neutrophil extracellular trap formation.

An Rv1471-Expressing Chimpanzee Adenovirus Vaccine Confers Protection against Tuberculosis by Inducing Alveolar Macrophage Trained Immunity and Polyfunctional T-Cell Responses

March 5, 2026

[Emerging Microbes & Infections] Researchers established the chimpanzee adenovirus vaccine expressing the Mtb antigen Rv1471 as a synergistic mucosal vaccine candidate that concurrently induces trained immunity in alveolar macrophages and polyfunctional T cell response.

Context-Specific Regulatory Genetic Variation in MTOR Dampens Neutrophil-T Cell Crosstalk in Pneumonia-Associated Sepsis

March 5, 2026

[Nature Communications] The authors characterize genetic variation that modulates MTOR, a critical regulator of metabolism and immune responses in sepsis.

Immune Escape Mechanisms and Therapeutic Advances in Virus-Associated Hematological Malignancies

March 5, 2026

[Blood Cancer Journal] The authors summarize the roles of various known viruses—particularly Epstein–Barr virus, human immunodeficiency virus, human T cell leukemia virus type 1, Kaposi’s sarcoma-associated herpesvirus, hepatitis B virus, and hepatitis C virus in the pathogenesis of hematological malignancies.

Dynamic Antigen Expression and Cytotoxic T Cell Resistance in HIV Reservoir Clones

February 25, 2026

[Nature] Scientists isolated and characterized authentic reservoir clones that robustly proliferate and accumulate while producing infectious virus, without overtly succumbing to cytopathicity.

Dartmouth Hitchcock Medical Center Wins $500K Grant to Increase Care Capabilities in Event of Serious Infectious Diseases

February 25, 2026

[DHMC] The National Emerging Special Pathogens Training and Education Center recently awarded Dartmouth Health’s Dartmouth Hitchcock Medical Center (DHMC) a $500,000 grant to build its capabilities as a Level 2 Special Pathogen Treatment Center.

Model Medicines Demonstrates First Single-Agent Antiviral Active Against Both Hepatitis C & Hepatitis B

February 25, 2026

[Model Medicines] Model Medicines announced preclinical data demonstrating that MDL-001 has potent antiviral activity against both hepatitis C virus (HCV) and hepatitis B virus (HBV). These results establish preclinical proof of concept for a single non-nucleoside agent targeting HCV/HBV co-infection.

The Immunometabolic Topography of Cellular Organization and Bacterial Control in Tuberculosis Granulomas

February 25, 2026

[Nature Immunology] Scientists found that a universal feature of tuberculosis granulomas is partitioning of the myeloid core into two distinct metabolic environments, one of which is hypoxic.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.