Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

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Dynamic Antigen Expression and Cytotoxic T Cell Resistance in HIV Reservoir Clones

February 25, 2026

[Nature] Scientists isolated and characterized authentic reservoir clones that robustly proliferate and accumulate while producing infectious virus, without overtly succumbing to cytopathicity.

Dartmouth Hitchcock Medical Center Wins $500K Grant to Increase Care Capabilities in Event of Serious Infectious Diseases

February 25, 2026

[DHMC] The National Emerging Special Pathogens Training and Education Center recently awarded Dartmouth Health’s Dartmouth Hitchcock Medical Center (DHMC) a $500,000 grant to build its capabilities as a Level 2 Special Pathogen Treatment Center.

Model Medicines Demonstrates First Single-Agent Antiviral Active Against Both Hepatitis C & Hepatitis B

February 25, 2026

[Model Medicines] Model Medicines announced preclinical data demonstrating that MDL-001 has potent antiviral activity against both hepatitis C virus (HCV) and hepatitis B virus (HBV). These results establish preclinical proof of concept for a single non-nucleoside agent targeting HCV/HBV co-infection.

The Immunometabolic Topography of Cellular Organization and Bacterial Control in Tuberculosis Granulomas

February 25, 2026

[Nature Immunology] Scientists found that a universal feature of tuberculosis granulomas is partitioning of the myeloid core into two distinct metabolic environments, one of which is hypoxic.

Conserved CD4+ T Cell Staphylococcal and Streptococcal Epitopes Enable Broad-Acting Vaccines in Mice

February 25, 2026

[Nature Microbiology] Researchers used immunopeptidomics to identify CD4+ T cell vaccine targets in methicillin-resistant Staphylococcus aureus.

B Cells Maintain the Homeostasis of Splenic Marginal Zone Antigen-Presenting Cells to Promote the Antiviral CD8+ T-Cell Response

February 25, 2026

[Cellular & Molecular Immunology] Using a murine cytomegalovirus infection model, investigators demonstrated that B cell-deficient mice mounted a weaker primary virus-specific CD8+ T-cell response than their wild-type counterparts did, which was associated with increased viral transcription.

Role of Autophagy in Antiviral Innate Immunity

February 25, 2026

[Cellular & Molecular Biology Letters] Certain viruses evolve mechanisms for inhibiting autophagy, enabling evasion of degradation and immune detection, since autophagy is frequently related to inflammatory diseases, including infections, autoimmune disorders, cancer, neurodegenerative conditions, and cardiovascular and liver diseases.

Human Oncogenic Herpesvirus Latency Proteins Activate NEK2 to Promote Chromosomal Instability and Tumorigenesis

February 25, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Epstein–Barr virus and Kaposi’s sarcoma–associated herpesvirus, both known to drive various malignancies, were observed to induce Never in mitosis A (NIMA)-related kinase 2 (NEK2) expression during both primary infection and latent phases of infection.

Antiviral Drug Discovery and Development: Challenges and Future Directions

February 25, 2026

[Signal Transduction and Targeted Therapy] The authors present a comprehensive timeline detailing the development of antiviral drugs, tracing the progression from early viral inhibitors to modern broad-spectrum antiviral agents.

Mucosal Vaccination in Mice Provides Protection from Diverse Respiratory Threats

February 23, 2026

[Science] Investigators described an intranasal liposomal formulation combining toll-like receptor 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus.

Attenuating Age-Related Decline in Dendritic Cell Migration Improves Vaccine Efficacy via Gut-Immune Crosstalk

February 23, 2026

[Nature Aging] Scientists identified defects in dendritic cell (DC) migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicated these defects in the diminished vaccine response observed in aging.

Nucleotide Signals Coordinate Activation and Inhibition of Bacterial Immunity

February 23, 2026

[Nature] Cryo-electron microscopy structures of deoxynucleoside triphosphohydrolase enzyme in activated and suppressed states reveal how dTTP and p3diT control distinct allosteric sites and regulate effector function.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.