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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Mucosal Vaccination in Mice Provides Protection from Diverse Respiratory Threats
[Science] Investigators described an intranasal liposomal formulation combining toll-like receptor 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus.
Attenuating Age-Related Decline in Dendritic Cell Migration Improves Vaccine Efficacy via Gut-Immune Crosstalk
[Nature Aging] Scientists identified defects in dendritic cell (DC) migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicated these defects in the diminished vaccine response observed in aging.
Nucleotide Signals Coordinate Activation and Inhibition of Bacterial Immunity
[Nature] Cryo-electron microscopy structures of deoxynucleoside triphosphohydrolase enzyme in activated and suppressed states reveal how dTTP and p3diT control distinct allosteric sites and regulate effector function.
Type I IFN-Dependent FcγRIV Signaling in Murine Monocytes Promotes Lethal Anaphylaxis during Viral Infections
[Journal of Clinical Investigation] Scientists observed increased frequencies of CD16-expressing classical monocytes in patients with acute COVID-19, and murine SARS-CoV-2 infection recapitulated this phenotype.
Ex Vivo Expanded Allogeneic Vδ2 T Cells Specifically Reduce Reservoirs of HIV-1 Following Latency Reversal
[JCI Insight] Researchers found expanded allogeneic Vδ2 T cells specifically eliminated HIV-infected CD4+ T cells and monocyte-derived macrophages, overcoming inherent resistance to killing by other cell types such as NK and CD8+ T cells.
Parenteral Vaccination with an Adjuvanted mRNA Vaccine Induces Protective Mucosal Immunity against Rotavirus in Neonatal Mice
[Science Translational Medicine] Researchers introduced a lipid nanoparticle platform that codelivers mRNA and the retinoic acid receptor agonist Am80, enabling antigen-specific mucosal immune responses in the gut via parenteral intramuscular vaccination.
Regnase-1-Mediated Regulation of Neutrophils Modulates SARS-CoV-2 Pneumonia
[PLoS Pathogens] Researchers showed that reduced expression of Regnase-1, an RNase that negatively regulates immune cell activation, confers resistance to infection with the mouse-adapted SARS-CoV-2 MA10 strain.
Synergistic Reprogramming of the Tumor Immune Microenvironment by Senecavirus a and STING Agonist
[Oncogene] Investigators demonstrate that combining a naturally isolated Senecavirus A strain with the STING agonist MSA-2 supports synergistic type I interferon activation across multiple tumor models.
Granulomas Microenvironment-Guided Sono-Immunotherapy to Treat and Prevent Recurrence of Tuberculosis
[Nature Communications] Scientists identified suppression of innate immune responses, especially downregulated Toll-like receptor/NF-kappa B pathways in macrophages/dendritic cells and elevated B/T cell negative regulation, contributing to treatment failure and recurrence.
B Cell Receptor’s Function in Virus Entry: Anti-SARS-CoV-2 B Cell Receptors Can Mediate Viral Entry in an ACE2-Independent Mechanism
[PLoS Pathogens] The authors demonstrated that the ability of anti-viral B cell receptors to mediate viral fusion/entry is not universal but depends on the specific viral envelope protein.
MHC Class II Functions As a Host-Specific Entry Receptor for Representative Human and Swine H3N2 Influenza a Viruses
[Nature Communications] Researchers showed that H3N2 viruses can use MHCII as an alternative entry receptor in a host-specific manner, and adaptation of human viruses to pigs increases affinity for the MHCII swine leukocyte antigen.
Ethris and German Center for Infection Research (DZIF) Announce Strategic Collaboration to Develop mRNA-Based Vaccines
[DZIF] Ethris GmbH and the German Center for Infection Research (DZIF) announced a strategic research collaboration to develop mRNA-based vaccines for the prevention and treatment of infectious diseases.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
