Effect of Delta Variant on Viral Burden and Vaccine Effectiveness against New SARS-CoV-2 Infections in the UK

Scientists found that the effectiveness of BNT162b2 and ChAdOx1 against infections with symptoms or high viral burden was reduced with the B.1.617.2 variant compared to the B.1.1.7 variant.
[Nature Medicine]
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Control of Host Mitochondria by Bacterial Pathogens

The authors discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
[Trends in Microbiology]
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Merck Receives Positive CHMP Opinion for VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) in Individuals 18 Years of Age and Older

Merck announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the approval of VAXNEUVANCE™ for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older.
[Merck (BusinessWire, Inc.)]
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Moderna Announces FDA Advisory Committee Unanimously Votes in Support of Emergency Use for a Booster Dose of Moderna’s COVID-19 Vaccine in the US

Moderna, Inc. confirmed that the FDA Vaccines and Related Biological Products Advisory Committee recommended that the FDA grant an Emergency Use Authorization for a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level for people aged 65 and older; people aged 18 to 64 who are at high risk of severe COVID-19; and people aged 18 to 64 whose exposure to COVID-19 puts them at risk for COVID-19 complications or severe illness.
[Moderna, Inc.]
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mTORC2 Confers Neuroprotection and Potentiates Immunity during Virus Infection

Scientists showed that mammalian target of rapamycin complex 2 was essential for the survival of experimental animals after ocular HSV-1 infection in vivo.
[Nature Communications]
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Organoid Models for Infectious Disease

Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions.
[Annual Review of Medicine]
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Cyclic CMP and Cyclic UMP Mediate Bacterial Immunity against Phages

Scientists reported that cCMP and cUMP were second messengers functioning in bacterial immunity against viruses. They discovered a family of bacterial pyrimidine cyclase enzymes that specifically synthesized cCMP and cUMP following phage infection.
[Cell]
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Nuclear-Localized Human Respiratory Syncytial Virus NS1 Protein Modulates Host Gene Transcription

Investigators observed NS1 partitioning into the nucleus of RSV-infected cells, including the human airway epithelium.
[Cell Reports]
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The S100A10–AnxA2 Complex Is Associated with the Exocytosis of Hepatitis B Virus in Intrauterine Infection

The authors investigated the mechanism as to how the hepatitis B virus virions pass through layers of the trophoblast.
[Laboratory Investigation]
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Safety, Tolerability and Antiviral Activity of the Antisense Oligonucleotide Bepirovirsen in Patients with Chronic Hepatitis B: A Phase II Randomized Controlled Trial

Investigators evaluated the safety and activity of an antisense oligonucleotide targeting hepatitis B virus (HBV) RNA in both treatment-naïve and virally suppressed individuals with chronic HBV infection.
[Nature Medicine]
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Monoclonal Antibodies from Humans with Mycobacterium tuberculosis Exposure or Latent Infection Recognize Distinct Arabinomannan Epitopes

The authors generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with M. tuberculosis.
[Communications Biology]
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