A Novel STING Agonist-Adjuvanted Pan-Sarbecovirus Vaccine Elicits Potent and Durable Neutralizing Antibody and T Cell Responses in Mice, Rabbits and NHPs

Researchers discovered a new STING agonist, CF501, and found that CF501-adjuvanted RBD-Fc vaccine elicited significantly stronger neutralizing antibody and T cell responses than Alum- and cGAMP-adjuvanted RBD-Fc in mice.
[Cell Research]
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Neutrophil Subsets and Their Differential Roles in Viral Respiratory Diseases

Scientists present an overview of neutrophil heterogeneity and its impact on the course and severity of viral respiratory infectious diseases.
[Journal of Leukocyte Biology]
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COVID-19 Vaccine Makers Chase Variant-Ready Vaccines

Pfizer aims to have an Omicron-specific COVID-19 vaccine ready by March. Assuming it gains approval, it will mark the first revision of its mRNA vaccine Comirnaty since the initial Emergency Use Authorization of the vaccine by the FDA on 11 December 2020.
[Nature News]
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The Pandemic’s True Death Toll: Millions More than Official Counts

On 1 November, the global death toll from the COVID-19 pandemic passed 5 million, official data suggested. It has now reached 5.5 million. But that figure is a significant underestimate. Records of excess mortality — a metric that involves comparing all deaths recorded with those expected to occur — show many more people than this have died in the pandemic.
[Nature News]
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Single-Dose SARS-CoV-2 Vaccinations with Either BNT162b2 or AZD1222 Induce Disparate Th1 Responses and IgA Production

Investigators compared the early immune responses against AZD1222 and BNT162b2. SARS-CoV-2 seronegative participants received a single dose of either vaccine and were analyzed for immune cell, effector T cell, and antibody dynamics.
[BMC Medicine]
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Hemagglutinin-Based DNA Vaccines Containing Trimeric Self-Assembling Nanoparticles Confer Protection against Influenza

Aiming to develop an effective vaccine with rapid production, robust immunogenicity, and high protective efficiency, a DNA vaccine was designed by fusing influenza virus hemagglutinin (HA) with self-assembled ferritin nanoparticles, denoted as HA-F.
[Journal of Leukocyte Biology]
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SARS-CoV-2 Infections in Children: Understanding Diverse Outcomes

The author discusses our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics and the higher incidence of rare multisystem inflammatory syndromes in children and young people.
[Immunity]
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Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA Vaccine–Elicited Human Sera

Following two doses, sera had over a 22-fold reduced neutralizing titers against Omicron compared to Wuhan pseudovirus.
[Science]
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Early Non-Neutralizing, Afucosylated Antibody Responses Are Associated with COVID-19 Severity

To study the biology afucosylated IgG immune complexes, researchers developed an in vivo model that revealed that human IgG-Fc gamma receptor interactions could regulate inflammation in the lung.
[Science Translational Medicine]
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US Would Seek Global Approach to Updating COVID-19 Vaccines, Official Says

A senior FDA official told STAT that the agency expects to take part in an internationally coordinated program aimed at deciding if, when, and how to update Covid-19 vaccines. The approach would ensure decisions are not left solely to individual vaccine manufacturers.
[STAT News]
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K63 Ubiquitination in Immune Signaling

The authors detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network.
[Trends in Immunology]
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