Humanigen and Avid Bioservices Enter Into cGMP Manufacturing Agreement for COVID-19 Therapeutic Candidate Lenzilumab in Support of Potential EUA Filing

Avid Bioservices, Inc. and Humanigen, Inc. announced that they have entered into a manufacturing services agreement to expand production capacity for lenzilumab™, Humanigen’s therapeutic candidate in development for COVID-19.
[Avid Bioservices, Inc. (BusinessWire, Inc)]
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SARS-CoV-2 Infects and Replicates in Cells of the Human Endocrine and Exocrine Pancreas

Scientists showed that SARS-CoV-2 infected cells of the human exocrine and endocrine pancreas ex vivo and in vivo. They demonstrated that human β-cells expressed viral entry proteins, and SARS-CoV-2 infected and replicated in cultured human islets.
[Nature Metabolism]
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COVID-19 Immune Features Revealed by a Large-Scale Single Cell Transcriptome Atlas

Scientists applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells. SARS-CoV-2 RNAs were found in diverse epithelial and immune cell types, accompanied by dramatic transcriptomic changes within viral positive cells.
[Cell]
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Viscoelastic Control of Spatiotemporal Order in Bacterial Active Matter

Researchers report a simple technique to simultaneously control the spatial and temporal self-organization of bacterial active matter. They confined dense active suspensions of Escherichia coli cells and manipulated a single macroscopic parameter through the addition of purified genomic DNA.
[Nature]
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Treatment of Influenza and SARS-CoV-2 Infections via mRNA-Encoded Cas13a in Rodents

Researchers designed CRISPR RNAs specific for PB1 and highly conserved regions of PB2 of influenza virus, and against the replicase and nucleocapsid genes of SARS-CoV-2, and selected the crRNAs that reduced viral RNA levels most efficiently in cell culture.
[Nature Biotechnology]
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A Single-Dose mRNA Vaccine Provides a Long-Term Protection for hACE2 Transgenic Mice from SARS-CoV-2

Scientists developed a nucleoside-modified mRNA vaccine in lipid-encapsulated form that encoded the SARS-CoV-2 RBD, termed as mRNA-RBD. A single immunization of mRNA-RBD elicited both robust neutralizing antibody and cellular responses, and conferred a near-complete protection against wild SARS-CoV-2 infection in the lungs of hACE2 transgenic mice.
[Nature Communications]
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VBI Vaccines Announces US FDA Acceptance of BLA Filing for VBI’s 3-Antigen Prophylactic Hepatitis B Vaccine

VBI Vaccines, Inc. announced that the FDA has accepted its filing of the Biologics License Application for the company’s 3-antigen prophylactic hepatitis B vaccine candidate for the prevention of infection caused by all known subtypes of the hepatitis B virus in adults.
[VBI Vaccines, Inc.]
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Three-Dimensional Low Shear Culture of Mycobacterium bovis BCG Induces Biofilm Formation and Antimicrobial Drug Tolerance

Researchers adapted a three-dimensional Rotary Cell Culture System to model M. bovis BCG biofilm growth in low-shear detergent-free liquid suspension.
[npj Biofilms and Microbiomes]
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Maturation and Persistence of the Anti-SARS-CoV-2 Memory B Cell Response

Scientists report a longitudinal single-cell and repertoire profiling of the B cell response up to six months in mild and severe COVID-19 patients.
[Cell]
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SARS-CoV-2 Spike Protein S1 Subunit Induces Pro-inflammatory Responses via Toll-Like Receptor 4 Signaling in Murine and Human Macrophages

Researchers examined the effects of SARS-CoV-2 spike protein S1 subunit on the pro-inflammatory responses in murine and human macrophages.
[Heliyon]
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Engineering SARS-CoV-2 Using a Reverse Genetic System

In response to the ongoing COVID-19 pandemic, scientists developed an infectious complementary DNA clone for SARS-CoV-2.
[Nature Protocols]
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