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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Human Gastroids to Model Regional Patterning in Early Stomach Development
[Nature] Scientists reported human gastroids, a self-organized multilineage gastric organoid derived from hPSCs to model gastric fundic-antral patterning in vitro.
Drug Delivery Strategies for the Lower GI Tract: A Review
[Advanced Healthcare Materials] The authors highlight the latest advancements and current limitations in targeted drug delivery strategies for the lower gastrointestinal tract, aiming to improve therapeutic outcomes and the quality of life for patients with intestinal disorders.
Gastric Cancer Treatment New Chapter: Organoid Models Leading Personalized Medicine
[Molecular Diagnosis & Therapy] Scientists explore the application of gastric cancer-derived organoids in preclinical research and clinical translation, highlighting current challenges and outlining future prospects.
Fructose Drives Colorectal Cancer Progression by Regulating Crosstalk Between Cancer-Associated Fibroblasts and Tumor Cells
[Gut] Investigators demonstrated that fructose plays a dual role in promoting colorectal cancer progression by influencing both tumour cells and cancer associated fibroblasts.
Multi-Omics Uncovers Transcriptional Programs of Gut-Resident Memory CD4+ T Cells in Crohn’s Disease
[Journal of Experimental Medicine] Researchers employed multilayered single-cell analytic approaches including chromatin, gene, and protein profiling to characterize a unique CD4+ TRM subset present in the inflamed gut mucosa of Crohn’s disease patients.
KDM4A-Induced Tumor Senescence Enhances the Efficacy of Immunotherapy by Inhibiting AGT-PHB1 Axis-Mediated Mitophagy in Colorectal Cancer
[Autophagy] Through integrated analysis of clinical cohorts and transcriptomic data across mismatch repair (MMR) subtypes, scientists identified cellular senescence as a hallmark of MMR deficient tumors, accompanied by elevated expression of lysine demethylase 4A (KDM4A).
Distinct Roles for B Cell-Derived LTα3 and LTα1β2 in TNF-Mediated Ileitis
[Nature Immunology] The authors hypothesized that B cell-derived LTαβ2 would critically affect ileitis in tumor necrosis factor (TNF)ΔARE+/− mice.
Lactiga Wins NIH Backing for First-in-Class Breastmilk-Derived Antibody in Inflammatory Bowel Disease
[Lactiga US, Inc. (BioSpace)] Lactiga US, Inc. announced it has received an award from the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases, to advance the development of its secretory IgA antibody for IBD.
Epithelial Tension Controls Intestinal Cell Extrusion
[Science] Researchers combined quantitative live microscopy, optogenetic induction of tissue tension, genetic perturbation of myosin II activity, and local disruption of the basal cortex in mouse intestines and intestinal organoids. They found that a local “tug-of-war” competition between contractile cells regulated extrusion in the intestinal epithelium.
NOX1 and NPY1R Mark Regional Colon Stem Cell Populations That Serve As Cancer Origins In Vivo
[Nature Cell Biology] Scientists report the identification of NOX1 and NPY1R as cell-surface markers enriched in LGR5+ stem cells predominantly within the cecum and exclusively within the middle and distal colorectum, respectively.
Aberrant PJA2-CHRM3 Signaling Creates a Therapeutic Vulnerability in Gastric Tumor
[British Journal of Cancer] Scientists constructed mouse gastric organoids to recapitulate the morphological and functional characteristics of diffuse-type gastric cancer for FDA-approved drug screening.
Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists
Intestinal Cell NewsMammary Cell NewsNeural Cell NewsNewslettersProstate Cell NewsPulmonary Cell News
[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
