Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

YD Bio Limited Expands OkaiDx™ Testing Portfolio to Pancreatic and Colorectal Cancer Detection Across the US and Provides Clinical Research Update on Pancreatic Cancer...

December 8, 2025

[YD Bio Limited] YD Bio Limited provided an update regarding US access to the OkaiDx^™ platform for post‑treatment breast cancer monitoring, detailing the continued expansion of OkaiDx^™ blood‑based testing platform to pancreatic and colorectal cancer detections while presenting new clinical advances in early pancreatic cancer detection.

Decay of Driver Mutations Shapes the Landscape of Intestinal Transformation

December 5, 2025

[Nature] The authors established that the presence of diverse priming events in the normal mouse intestinal epithelium can change the transformation and clonal-selection landscape, permitting the fixation of strong driver mutations in Apc and Ctnnb1 that are otherwise lost due to negative selection.

A Niche-Dependent Redox Rheostat Regulates Epithelial Stem Cell Fate

December 5, 2025

[Nature Communications] Scientists showed that cellular redox balance orchestrates niche factors with metabolic state to govern cell fate decisions.

Iron Homeostasis and Cell Clonality Drive Cancer-Associated Intestinal DNA Methylation Drift in Aging

December 5, 2025

[Nature Aging] By analyzing DNA methylation and gene expression data from healthy and cancerous human colon samples, investigators identified an aging and colon cancer-associated DNA methylation drift.

RNA-Binding Protein HnRNPU Regulates Proliferation and Ferroptosis in Colon Adenocarcinoma by Stabilizing the mRNA of System Xc−

December 5, 2025

[Experimental & Molecular Medicine] The authors identified increased heterogeneous nuclear ribonucleoprotein U (HnRNPU) expression in patients with colon adenocarcinoma, with higher levels correlating with poor patient survival.

TAF1 Acetyltransferase Promotes Colorectal Carcinoma Metastasis by Catalyzing β-hydroxybutyrylation of KCTD9

December 5, 2025

[Oncogene] Researchers identified that TATA-binding protein-associated factor-1 (TAF1), also as a lysine acetyltransferase, is frequently upregulated in colorectal cancer.

A GPER-PKA-Centrin Axis Regulates Centrosome Numbers and Centriole Integrity in Colon Cancer Cells

December 5, 2025

[Communications Biology] Scientists showed that protein Kinase A (PKA) is central to a signaling cascade involving the G protein-coupled estrogen receptor GPER1, which is essential for centrosome integrity in colon cancer cells.

Same Mutation, Different Fates: The Yin-Yang of BRAF-Driven Therapeutic Responses in Melanoma and Colorectal Cancer

December 5, 2025

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors dissect the “yin-yang” of BRAF as a therapeutic vulnerability in in melanoma and colorectal cancer and underscore the critical importance of tumor-specific context in precision oncology.

Camilla Engblom One of This Year’s Wallenberg Academy Fellows

December 5, 2025

[Karolinska Institute] One of the young researchers receiving Knut and Alice Wallenberg Foundation’s basic research grant this year is Camilla Engblom. She will use the funding to study a piece of the puzzle that could help develop more precise and personalized treatments for cancer and inflammatory bowel disease.

Imfinzi Approved in the US As First and Only Perioperative Immunotherapy for Patients with Early Gastric and Gastroesophageal Cancers

November 28, 2025

[Astrazeneca] AstraZeneca’s Imfinzi in combination with standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel chemotherapy has been approved in the US for the treatment of adult patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction cancers.

Paneth-Like Transition Drives Resistance to Dual Targeting of KRAS and EGFR in Colorectal Cancer

November 21, 2025

[Cancer Cell] Using genetically engineered mouse models, patient-derived organoids and xenografts, as well as clinical specimens, scientists discovered that colorectal tumors surviving combined KRAS and EGFR inhibition acquire a Paneth-like cell state—a secretory lineage typically confined to the intestinal crypt.

UMP Functions As an Endogenous Regulator of NR4A1 to Control Gastric Cancer Progression

November 21, 2025

[Molecular Cell] Investigators identified UMP as an endogenous regulator of the orphan nuclear receptor NR4A1 in gastric cancer.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.