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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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USP11 Promotes Colorectal Cancer Progression by Stabilizing EGFR and TRAF6: A Potential Therapeutic Target in EGFR- and TLR-Driven Tumorigenesis
[Cell Death & Disease] Researchers investigated the role of ubiquitin-specific protease (USP) 11 in colorectal cancer (CRC) pathogenesis. RNA-seq analysis of tumor and matched normal tissues from 35 CRC patients identified USP11 as significantly overexpressed in tumor samples.
YTHDF1 Targets the Chemotherapy Response by Suppressing NOTCH1-Induced Stemness in Colorectal Cancer
[Signal Transduction and Targeted Therapy] Investigators found that the N6-methyladenosine reader YT521-B homologous domain family, member 1 (YTHDF1), promotes colorectal cancer stemness, tumorigenesis, and chemotherapy resistance.
AQP5: A Functional Gastric Cancer Stem Cell Marker in Mouse and Human Tumors
[Science] Scientists reported that the surface marker AQP5 enriches for gastric CSCs in mouse and human tumors arising from the distal pyloric stomach.
Epithelial WNT Secretion Drives Niche Escape of Developing Gastric Cancer
[Molecular Cancer] Researchers analyzed mouse gastric organoids harboring oncogenic KRASG12D with or without RNF43/ZNRF3 or CDH1/TP53 mutations, along with corresponding in vivo mouse models.
BE Screen Reveals METTL3 S2 Dephosphorylation Sensitizes Gastric Cancer Cells to Oxaliplatin by Interfering METTL3-eIF3H Interaction
[Science Advances] In GC cell line AGS, high-throughput base editor screen identified key phosphorylation sites associated with oxaliplatin response.
SLAP Controls mTORC2 Integrity via UBE3C-Mediated Non-Degradative mLST8 Ubiquitination to Suppress Colorectal Tumorigenesis
[Cell Death & Differentiation] Investigators showed that the Src-Like Adaptor Protein (SLAP), a negative regulator of tyrosine kinase signaling receptors, controls mTORC2 integrity to mediate its tumor-suppressive function in colorectal cancer.
FUT3 Mediated GRP78 Fucosylation Promotes Colorectal Cancer Survival and Proliferation under Glucose Restriction via PERK/ATF4/STC2 Axis
[NPJ Precision Oncology] The authors demonstrated that colorectal cancer cells exhibit high expression of FUT3 under glucose-deficient conditions and that FUT3 directly binds to GRP78, inducing its fucosylation.
The Cancer-Testis lncRNA LINC01940 Promotes Gastric Cancer Malignant Progression and Chemoresistance by Enhancing Ribosome Biogenesis via TAF15-Mediated NOL11 SUMOylation
[Cellular & Molecular Biology Letters] Scientists performed a screening of lncRNAs and identified CT-lncRNA LINC01940 on the basis of integrated expression and survival analyses using The Cancer Genome Atlas data.
A Dual-Functional Cobalt Ferrite Nanocomplex for Targeted Cisplatin Prodrug Delivery and MALAT1 Gene Silencing in Gastric Cancer Cells
[Scientific Reports] Researchers used magnetic cobalt ferrite nanoparticles, functionalized with polyethyleneimine and chitosan, as targeted carriers for delivering Pt(IV)-COOH prodrug and shRNA-expressing cassettes to AGS cells.
Unveiling Hidden Players: The Role of Intratumoral Microbiota in Gastrointestinal Cancer Dynamics
[Journal of Cancer Research and Clinical Oncology] The authors summarize key developments in understanding the role of the intratumoral microbiota in gastrointestinal cancers and discusses future directions for translating these insights into clinical applications.
Shilpa S. Murthy Receives 1.1 Million DoD Career Development Award
[Yale School of Medicine] Dr. Shilpa Murthy has been awarded a prestigious $1.1 million Career Development Award from the Department of Defense (DoD).
YD Bio Limited Expands OkaiDx™ Testing Portfolio to Pancreatic and Colorectal Cancer Detection Across the US and Provides Clinical Research Update on Pancreatic Cancer...
[YD Bio Limited] YD Bio Limited provided an update regarding US access to the OkaiDx™ platform for post‑treatment breast cancer monitoring, detailing the continued expansion of OkaiDx™ blood‑based testing platform to pancreatic and colorectal cancer detections while presenting new clinical advances in early pancreatic cancer detection.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
