Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Obesity Impairs Gut Repair via AFABP-Mediated Iron Overload in Intestinal Stem Cells

January 23, 2026

[Nature Metabolism] Scientists showed that adipocyte fatty acid-binding protein (AFABP), an adipokine involved in fatty acid transport, impedes intestinal repair by disrupting iron homeostasis in intestinal stem cells.

Targeting the N-Acetyltransferase 10/DKK2 Axis Enhances CD8+ T Cell Antitumor Activity in Colorectal Cancer Models

January 23, 2026

[Journal of Clinical Investigation] Investigators revealed that f N-acetyltransferase 10 in colorectal cancer promotes immune evasion through N4-acetylcytosine–dependent mRNA stabilization.

G9a-Mediated H3K9me2 Orchestrates Intestinal Epithelial Regeneration through Epigenetic Silencing of Cell Cycle-Related Genes

January 23, 2026

[Nature Communications] Researchers identified histone H3 lysine 9 di-methylation (H3K9me2) as an epigenetic regulator of intestinal epithelial repair through mass spectrometry-based screening of histone modifications.

Basal IFNλ2/3 Signaling Is Required for ISG Expression and Viral Control in Human Intestinal Epithelial Cells

January 23, 2026

[PLoS Pathogens] Researchers systematically investigated the distinct roles of Interferon-lambda 1 (IFNλ1) and IFNλ2/3 in regulating intrinsic antiviral immunity using human intestinal epithelial T84 cells.

Distinct SOX9 Single-Molecule Dynamics Characterize Adult Differentiation and Fetal-Like Reprogrammed States in Intestinal Organoids

January 23, 2026

[Stem Cell Reports] The authors revealed an expression-level-independent decrease in the fraction of immobile sex-determining region Y box 9 (SOX9) molecules during differentiation from ∼48% to ∼38%, largely dependent on DNA binding.

Role of Colorectal Cancer-Derived Exosomes in Modulating Macrophage Phenotypes during Tumor Development

January 23, 2026

[Carcinogenesis] Scientists provided evidence that communication between colorectal cancer and immune cells, particularly tumor-associated macrophages, occurs through the release of soluble factors and extracellular vesicles, such as exosomes.

Effects of Extensive Protein Hydrolysate in Supporting Intestinal Barrier Function In Vitro

January 23, 2026

[Pediatric Research] Researchers examined the impact of cow’s milk-derived extensively hydrolyzed proteins, widely used in formulas and human milk fortifiers, on intestinal barrier function and gene expression in fetal human intestinal organoid-derived monolayers, modeling premature epithelium.

Immunity at the Edge: Cell-Intrinsic Roles for Intestinal Epithelial Cells in Host Immunity

January 23, 2026

[Journal of Leukocyte Biology] Investigators discuss the role of intestinal epithelial cells in responding to infection by intracellular bacteria, parasites, and viruses.

Review on Advances in Small Molecule Inhibitors on the Treatment of Inflammatory Bowel Disease

January 23, 2026

[Molecular Biology Reports] The authors classifie the currently utilized small molecule inhibitors for IBD not by their targets but by their molecular chemical structures.

Guardant Health Receives FDA Approval for Guardant360® CDx as Companion Diagnostic for BRAFTOVI® (encorafenib) Combination in Patients with BRAF V600E-Mutant Metastatic Colorectal Cancer

January 23, 2026

[Guardant Health, Inc.] Guardant Health, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved Guardant360^® CDx as a companion diagnostic to identify patients with BRAF V600E-mutant metastatic colorectal cancer who may benefit from treatment with BRAFTOVI^® in combination with cetuximab and chemotherapy in accordance with the approved product labeling.

β-Catenin/TCF4/NANOG Axis Controls miR-302 Transcription in Colorectal Cancer Cells

January 20, 2026

[Gene] Scientists demonstrated that the β-catenin/TCF4 complex significantly enhances miR-302 expression through direct promoter activation in colorectal cancer cells.

The Dysadherin/Carbonic Anhydrase 9 Axis Shapes an Acidic Tumor Microenvironment to Promote Colorectal Cancer Progression

January 20, 2026

[Signal Transduction and Targeted Therapy] Researchers demonstrated that the membrane glycoprotein dysadherin promotes colorectal cancer malignancy by modulating tumor microenvironment acidity.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.