Mucus Layer Modeling of Human Colonoids during Infection with Enteroaggragative E. coli

Investigators used human colonoids comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic’s roles during infection with EAEC.
[Scientific Reports]
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Amending Microbiota by Targeting Intestinal Inflammation with TNF Blockade Attenuates Development of Colorectal Cancer

Using chemically induced and spontaneous mouse colorectal cancer (CRC) models colonized by colibactin-producing Escherichia coli, scientists established the role of microbiota in mediating the antitumorigenic effect of anti–tumor necrosis factor (TNF) therapy. They found that TNF blockade attenuated colitis and CRC development
[nature cancer]
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Natera Announces First Patient Enrollments in Both CIRCULATE-Japan and BESPOKE CRC Trials Using SignateraTM MRD Testing

Natera, Inc.announced that enrollment has begun in the CIRCULATE-Japan and BESPOKE CRC trials, with both studies experiencing strong interest from centers across Japan and the U.S The studies will measure clinical outcomes of Signatera molecular residual disease testing in resectable Stages II-IV colorectal cancer.
[Natera]
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CD47 Is a Negative Regulator of Intestinal Epithelial Cell Self-Renewal Following Dss-Induced Experimental Colitis

Scientists revealed CD47 as a negative regulator in intestinal epithelial cell renewal during colitis through downregulating OSKM transcriptional factors.
[Scientific Reports]
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Enalapril Overcomes Chemoresistance and Potentiates Antitumor Efficacy of 5-FU in Colorectal Cancer by Suppressing Proliferation, Angiogenesis, and NF-κB/stat3-Regulated Proteins

Researchers verified enalapril, a clinically widely used antihypertensive and anti-heart failure drug, as a chemosensitizer that improves sensitivity of colorectal cancer cells to 5-Fluorouracil.
[Cell Death & Disease]
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Exosomes Transfer miRNAas from Cell-To-Cell to Inhibit Autophagy During Infection with Crohn’s Disease-Associated Adherent-Invasive E. coli

Investigators showed that upon Adherent-invasive E. coli (AIEC) infection, intestinal epithelial cells(IECs) secreted exosomes that could transfer specific miRNAs to recipient IECs, inhibiting autophagy-mediated clearance of intracellular AIEC.
[Gut Microbes]
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PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells

Scientists suggested that the pre-mRNA processing factor 4B kinase domain was responsible for promoting drug resistance to curcumin by inducing EMT.
[Molecules and Cells]
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Wnt-Driven LARGE2 Mediates Laminin-Adhesive O-Glycosylation in Human Colonic Epithelial Cells and Colorectal Cancer

Investigators revealed that Wnt activity triggered the expression of the gene, LARGE2, which in turn mediated the laminin- adhesive O-glycosylation of α-DG. They found abnormally increased cellular adhesion to laminin during Wnt-driven cancer progression.
[Cell Communication and Signaling]
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MiR-200b in Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Alleviates Inflammatory Injury of Intestinal Epithelial Cells by Targeting High Mobility Group Box 3

Scientists identified that exosomes derived from HO-1/BMMSCs played an important role in alleviating the inflammatory injury of intestinal epithelial cells (IECs). The mechanism was related to miR-200b targeting the abnormally increased expression of the high mobility group box 3 (HMGB) gene in IECs induced by inflammatory injury. The reduced level of HMGB3 then decreases the inflammatory injury.
[Cell Death & Disease]
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Spermine Synthase and Myc Cooperate to Maintain Colorectal Cancer Cell Survival by Repressing Bim Expression

Researchers uncover a key survival signal in colorectal cancer through convergent repression of Bim expression by distinct SMS- and MYC-mediated signaling pathways.
[Nature Communications]
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Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Investigators demonstrated that the artificial sweeteners sucralose, aspartame, and saccharin exerted a range of negative effects on the intestinal epithelium through the sweet taste receptor T1R3.
[Nutrients]
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