Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Biomimetic Culture Substrates for Modeling Homeostatic Intestinal Epithelium In Vitro

May 9, 2025

[Nature Communications] Investigators presented a strategy for replicating the intricate microenvironment of the intestine by cultivating intestinal cells within bioinspired 3D interfaces that recapitulate the villus-crypt architecture and 3D tissue arrangement of the intestine.

NAG-1/GDF15 As a Tumor Suppressor in Colorectal Cancer: Inhibition of β-catenin and NF-κB Pathways via Interaction with EpCAM

May 9, 2025

[Cell Death & Disease] Scientists revealed its crucial role in suppressing oncogenic signaling. They demonstrated that pro-NAG-1/GDF15 is predominantly retained within cells, whereas its mature form is secreted into the media.

The Protective Role of PYY in Intestinal Mucosal Defects Induced by SATB2 Deficiency in Inflammatory Bowel Disease

May 9, 2025

[Cell Death Discovery] Flow cytometry was used to assess special AT-rich sequence-binding protein 2 (SATB2)’s role in colonic epithelial repair in a radiation injury model. SATB2 knockout mice exhibit defective epithelial repair, with a marked reduction in goblet and enteroendocrine cells.

Autophagy Regulates Putative Anion Transporter 1 Expression in Intestinal Epithelial Cells

May 9, 2025

[Journal of Cellular and Molecular Medicine] Autophagy in Caco-2 cells was induced by either rapamycin treatment or by nutrient deprivation and assessed by conventional autophagy marker proteins.

Bardoxolone Methyl Suppressed Colorectal Cancer Cells In Vitro by Inhibiting the PI3K Signaling Pathway

May 9, 2025

[Scientific Reports] The authors investigated bardoxolone methyl (CDDO-Me), a synthetic triterpenoid, as a potential therapeutic agent for colorectal cancer (CRC). Integrating network pharmacology, bioinformatic analyses, and in vitro assays, they evaluated the effects of CDDO-Me on CRC cells.

Dietary 3-Aminobenzoic Acid Enhances Intestinal Barrier Integrity and Attenuates Experimental Colitis

May 9, 2025

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Researchers identified 3-aminobenzoic acid, a dietary component abundant in azuki beans, soybeans and chickpeas as a regulator of epithelial permeability and inflammation in the colon.

Development and Characterization of a 2D Porcine Colonic Organoid Model for Studying Intestinal Physiology and Barrier Function

May 9, 2025

[PLOS One] Investigators developed and characterized a two-dimensional in vitro model of porcine colonic organoids that closely mimics native colon tissue, thereby supporting in vitro research in gastrointestinal physiology, pathology, and pharmacology.

LncRNA NEAT1 Protects Uremic Toxin-Induced Intestinal Epithelial Barrier Injury by Regulating mir-122-5p/Occludin Axis

May 9, 2025

[PLOS One] Human colon cancer cells were used to establish intestinal epithelial injury models with the urea treatment in different conditions.

A Bioligical Perspective on the Role of Mir-206 in Colorectal Cancer

May 9, 2025

[Gene] The specific biological functions and complete mechanistic understanding of miR-206 in colorectal cancer (CRC) remain largely uncharacterized. The authors provide a comprehensive analysis of miR-206′s role in CRC.

UTR Therapeutics Inc Announces IND Submission to the US FDA for a First-in-Human Clinical Trial of an mRNA Destabilizing Drug Targeting c-MYC Driven Cancers

May 9, 2025

[UTR Therapeutics (Globenewswire)] UTR Therapeutics Inc. announced a new milestone, the submission of an Investigational New Drug (IND) application to the US FDA for UTRxM1-18, a novel therapeutic approach for targeting c-MYC driven cancers.

Exogenous TSG-6 Treatment Alleviates DSS-Induced Colitis in Mice by Modulating Pou2f3 and Promoting Tuft Cells Differentiation

May 2, 2025

[Molecular Medicine] Scientists explored how TSG-6 regulated the intestinal epithelial barrier and its mechanistic role in experimental colitis.

Whole-Exome Tumor-Agnostic ctDNA Analysis Enhances Minimal Residual Disease Detection and Reveals Relapse Mechanisms in Localized Colon Cancer

May 2, 2025

[Nature Cancer] The authors performed whole-exome sequencing of circulating tumor DNA (ctDNA) at different time points in participants with relapsed colon cancer in two independent cohorts, alongside transcriptomic and proteomic analyses of metastases, to enhance comprehension of progression mechanisms.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.