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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Snora54 Negatively Regulates Self-Renewal of Intestinal Stem Cells and Gut Regeneration via Suppression of Notch2 Signaling
[Science Advances] Investigators identified a small nucleolar RNA (Snora54) that was highly expressed in the nucleolus of intestinal stem cells (ISCs). Snora54 knockout enhanced the self-renewal capacity of ISCs and intestinal regeneration.
Fucosyltransferase 11 Restrains Ferroptosis via Upregulation GPX4 Expression in Gastric Cancer
[BMC Cancer] Investigators found that FUT11 expression is abnormally high in gastric cancer (GC) cells and that the prognosis of patients with GC and high expression of FUT11 is poor.
CDX1 and CDX2 Suppress Colon Cancer Stemness by Inhibiting β-Catenin-Facilitated Formation of Pol II-DSIF-PAF1C Complex
[Cell Death & Disease] The authors showed that complete loss of Cdx1 or concurrent loss of Cdx1/2 increased the stemness and malignancy of intestinal tumors.
Biodexa Announces Award of Additional $3.0M Grant from CPRIT to Support Registrational eRapa Phase III Program in FAP Brings Total CPRIT Grant Funding for...
[Biodexa Pharmaceuticals PLC] Biodexa Pharmaceuticals PLC announced its collaboration partner, Rapamycin Holdings, Inc. d/b/a Emtora Biosciences has been awarded an additional grant of $3.0 million from the Cancer Prevention & Research Institute of Texas.
S-Adenosylmethionine Metabolism Shapes CD8+ T Cell Functions in Colorectal Cancer
[Cancer & Metabolism] Scientists used untargeted metabolomics to investigate the metabolic heterogeneity in patients with colorectal cancer.
Morin Induces Autophagy-Dependent Ferroptosis in Colorectal Cancer Cells by Inhibiting the AURKB-UCHL3 Interactions
[Cellular Signalling] Molecular docking predicted potential binding between morin and AURKB. Experimental validation included qPCR, Western blotting, co-immunoprecipitation, and immunofluorescence.
PRMT1-Catalyzed NUSAP1 Methylation Enhances Notch2 Signaling and 5-FU Resistance in Gastric Cancer
[Cell Death & Disease] Researchers identified NUSAP1, a nucleolar and spindle-associated protein, as a key driver of 5-fluorouracil (5-FU) resistance in gastric cancer.
Early Immune Evasion in Colorectal Cancer: Interplay between Stem Cells and the Tumor Microenvironment
[Trends in Cancer] Scientists discuss how early driver mutations and epigenetic alterations contribute to the establishment of an immunosuppressive microenvironment in colorectal cancer
Hydrogen Sulfide Preserves Intestinal Barrier Repair Function through Sulfhydration of RPS20 in Experimental Colitis
[Scientific Reports] The experimental content includes the establishment of a mouse DSS-induced colitis mouse model, mouse colon epithelial organoids culture, H&E staining, and mass spectrometry analysis.
Latest Advanced Techniques for Improving Intestinal Organoids Limitations
[Stem Cell Reviews and Reports] Investigators elucidate the principal limitations of intestinal organoids and investigate structural defects.
TGF-β Signaling Redirects Sox11 Gene Regulatory Activity to Promote Partial EMT and Collective Invasion of Oncogenically Transformed Intestinal Organoids
[Oncogenesis] Researchers used intestinal organoids with colorectal cancer driver mutations as model system to investigate the mechanistic basis of TGF-β1-induced partial epithelial-mesenchymal transitions and collective invasion.
Biomimetic Culture Substrates for Modeling Homeostatic Intestinal Epithelium In Vitro
[Nature Communications] Investigators presented a strategy for replicating the intricate microenvironment of the intestine by cultivating intestinal cells within bioinspired 3D interfaces that recapitulate the villus-crypt architecture and 3D tissue arrangement of the intestine.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
