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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
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Landscape of Gene Fusions in Hormone Receptor-Positive Breast Cancer Reveals ADK Fusions As Drivers of Progression and Potential Therapeutic Targets
[Cell Discovery] Researchers leveraged a large-scale multiomics cohort and a drug screening platform for breast cancer to systematically profile gene fusions.
METTL3-Dependent m6a RNA Methylation Suppresses Aberrant Mammary Epithelial Differentiation and Neoplastic Transformation
[Proceedings of The National Academy of Sciences of The United States of America] Scientists showed that METTL3-dependent m6A methylation is essential for maintaining epithelial hierarchy by repressing aberrant luminal gene expression.
RPS24 Microexon Isoform As a Novel Biomarker for Estrogen Receptor-Positive Breast Cancer Progression and Therapeutic Resistance
[Experimental & Molecular Medicine] The authors identified notable variations in ribosomal protein S24 (RPS24) splicing patterns across breast cancer subtypes and investigated this novel regulatory mechanism.
Imidacloprid Actions in the Mouse Mammary Gland Structure and Epithelial Mammary Cells. Role of GPER and nAChR
[Environmental Research] Researchers examined the imidacloprid (IMI) effect on the mammary gland in a peripuberal model where female mice were exposed to IMI.
YTHDF3 Promotes Breast Cancer Osteolytic Bone Metastasis by Enhancing the Translation of ZEB1 and SMAD5
[Oncogenesis] Investigators found YTH domain-containing family protein 3 (YTHDF3) expression was associated with clinical characteristics of breast cancer patients. YTHDF3 expression influenced the migration and invasion capacity of breast cancer cells in vitro and in vivo.
Microtubule Dependent Changes in Cell Polarity Are Required for Mammary Epithelial Cell Migration and Branching Morphogenesis
[Biology Open] Using organotypic cultures, investigators first examined the organization of the microtubule cytoskeleton. Simple luminal epithelial cells exhibited non-centrosomal, apico-basally oriented microtubule arrays, while stratified luminal cells had centrosomally-radiating microtubules.
Peroxiredoxins: Regulatory Roles and Potential Clinical Significances in Breast Cancer
[Free Radical Research] The authors review the differential expression and functional characteristics of peroxiredoxins across various molecular subtypes of breast cancer, with a particular focus on TNBC.
Success for UOC Researchers in Canterbury Medical Research Foundation Grants
[University of Otago] Dr. George Wiggins is a recipient of the Canterbury Medical Research Foundation's $220,000 Emerging Researcher Grant for his work investigating potential novel preventative therapies for women at high risk of breast and ovarian cancers.
FTO Promotes the Progression of Triple-Negative Breast Cancer by Regulating the M6a Methylation of NFKBIE
[Clinical and Experimental Medicine] The authors elucidated a novel mechanistic link between FTO and NFKBIE/MAPK signaling in TNBC pathogenesis, providing critical insights for future therapeutic strategies targeting this recalcitrant disease.
Identification and Analysis of Metabolic Reprogramming-Related Genes in Triple-Negative Breast Cancer
[Clinical and Experimental Medicine] Scientists identified specific genes associated with metabolic reprogramming in TNBC, which can potentially become unique biomarkers of this cancer.
IL-3/STAT5/Mir-155-5p Axis Supports Stem-Related Pathway Reprogramming in TNBC
[Breast Cancer Research] Researchers explored the IL-3 mechanism of action in TNBC and particular attention has been dedicated to investigating the impact of miR-155-5p in IL-3-mediated TNBC aggressiveness.
Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 Are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer
[Cell Death & Disease] Scientists hypothesize that NR4A1/2 may be important drug targets in TNBC due, in part, to their regulation of ferroptosis and key ferroptotic genes.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
