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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Distinct and Convergent Effects of Mutations in Human Breast Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Characterization of the largest SF3B1 mutant breast cancer clinical cohort to date identifies SF3B1 driver mutations in approximately 2.5% of HR+ HER2- breast cancer, with strong enrichment of K700E substitution.
Metabolic Interplay Between Exogenous Cystine and Glutamine Dependence in Triple-Negative Breast Cancer
[Cell Death Discovery] Researchers demonstrated that TNBC cells exhibit sensitivity to individual nutrient deprivation but can survive dual cystine and glutamine deprivation via distinct mechanisms.
Interactions Between LncRNAs and MAPK Signaling Pathways in the Pathogenesis of Breast Cancer
[Cancer Cell International] The authors provide insight into breast cancer biology and highlight the potential, as well as the limitations, of leveraging long non-coding RNAs (lncRNA)-mitogen-activated protein kinase (MAPK) interactions for improved diagnostic and therapeutic strategies.
Therapeutic Suppression of Triple-Negative Breast Cancer via Pachymic Acid-Induced KIF18B Inhibition and Ferroptosis Activation
[Molecular Carcinogenesis] Investigators demonstrated that pachymic acid suppresses TNBC progression by inducing ferroptosis and inhibiting malignant phenotypes through kinesin family member 18B (KIF18B) downregulation.
Exogenous Kisspeptin-10 Treatment Shows Pleiotropy via Induction of KISS1 Expression, Metastasis Suppression, and Promotes Apoptosis in Triple-Negative Breast Cancer
[Scientific Reports] The authors elucidated the detailed role of kisspeptin in TNBC, focusing on its expression, functional significance, and therapeutic potential.
NCCN Awards Funding to Improve Care for People with Breast Cancer
[NCCN®] The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program announced new funding for quality improvement initiatives in breast cancer to help advance patient outcomes.
BCRF to Honor Dr. Robert Vonderheide with 2025 Jill Rose Award
[BCRF] The Breast Cancer Research Foundation (BCRF) is thrilled to award its highest scientific honor, the Jill Rose Award for Scientific Excellence, to Dr. Robert Vonderheide, a leading authority in cancer immunology.
Targeting ESR1 Restores SQSTM1-Dependent Autophagy and Sensitizes ER-Positive Breast Cancer to Oxidative and Radiation Stress
[Cell Death Discovery] Functional studies using estrogen receptor alpha (ESR1) overexpression and knockdown models revealed that depletion of ESR1 sensitized cells to radiation-induced DNA damage, impaired DNA repair efficiency, and reduced clonogenic survival.
Decoding BRCA1 Promoter Hypermethylation: A New Frontier in Understanding Sporadic Breast Cancer
[Cancer Gene Therapy] Scientists employed a modified CRISPR approach to induce site-specific methylations in the wild-type BRCA1 promoter, mimicking BRCA1 promoter hypermethylation under clinical conditions.
Spatiotemporal Microenvironment Landscape and Malignant Epithelial Pattern Transition in Breast Ductal Carcinoma Progression
[Journal of Translational Medicine] Single-cell sequencing, spatial transcriptomics, and bulk RNA sequencing datasets were used to explore the changes in microenvironmental components and transcriptional programs of tumor cells during the progression of breast ductal carcinoma.
A 3D Genome Compendium of Breast Cancer Progression
[iScience] Using breast cancer as a model, researchers have profiled the 3D genome throughout the natural course of the disease; from development to progression.
BCRF Awards Record-Breaking $74.75M in Year of Exceptional Turmoil in Scientific Funding
[BCRF] The Breast Cancer Research Foundation (BCRF) announced a record-breaking $74.75 million investment in breast cancer research, funding more than 260 scientists across 16 countries. This investment spans the full continuum of the disease, from prevention and early detection to metastatic breast cancer.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
