Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
HOXB5 Promotes the Progression and Metastasis of Osteosarcoma Cells by Activating the JAK2/STAT3 Signaling Pathway
[Heliyon] The expression of homeobox gene B5 (HOXB5) in human osteosarcoma tissues and its correlation with clinical indicators were investigated using bioinformatics analysis and immunohistochemical labelling.
The Potency of Mesenchymal Stem/Stromal Cells: Does Donor Sex Matter?
[Stem Cell Research & Therapy] The authors summarize published studies demonstrating donor-sex-related MSC heterogeneity and emphasize the importance of disclosing donor sex as a key factor affecting MSC potency in cell therapy.
Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class PRAME-Targeted T-cell Receptor Natural Killer (TCR-NK) Cell Therapy for Hematological Malignancies
[Replay] Replay and The University of Texas MD Anderson Cancer Center announced that the FDA has issued a ‘safe to proceed’ for the Investigational New Drug (IND) application for PRAME TCR/IL-15 NK (SY-307) for relapsed/refractory myeloid malignancies.
In Vitro Anti-leukemic Effect of Wharton’s Jelly Derived Mesenchymal Stem Cells
[Molecular Biology Reports] Wharton’s Jelly-derived-MSCs were isolated from human umbilical cord. The cells were incubated according to the standard culture conditions and characterized by flow cytometry.
Mesenchymal Stromal/Stem Cells Promote Intestinal Epithelium Regeneration after Chemotherapy-Induced Damage
[Stem Cell Research & Therapy] Single cell human small intestine organoids were embedded in Matrigel, grown for five days and treated with busulfan for 48 hours.
rhBMP-2 Induces Terminal Differentiation of Human Bone Marrow Mesenchymal Stromal Cells Only by Synergizing with Other Signals
[Stem Cell Research & Therapy] Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow MSCs were tested in an in vivo subcutaneous implantation model to assess their ability to form mature bone and undergo multilineage differentiation.
Hematopoietic Stem Cell Niche Generation and Maintenance Are Distinguishable by an Epitranscriptomic Program
[Cell] Investigators compared perinatal and adult bone marrow MSCs. MSCs exhibited enrichment in genes mediating m6A mRNA methylation at the perinatal stage and downregulated the expression of Mettl3 shortly after birth.
Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes
[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.
Design of a Stem Cell–Based Therapy for Ependymal Repair in Hydrocephalus Associated with Germinal Matrix Hemorrhages
[Stroke] Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.
Oncogene-Induced Matrix Reorganization Controls CD8+ T Cell Function in the Soft-Tissue Sarcoma Microenvironment
[European Journal Of Clinical Investigation] Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.
Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells
[Advanced Materials] Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.
Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics
[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
