rhBMP-2 Induces Terminal Differentiation of Human Bone Marrow Mesenchymal Stromal Cells Only by Synergizing with Other Signals

Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow MSCs were tested in an in vivo subcutaneous implantation model to assess their ability to form mature bone and undergo multilineage differentiation.