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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
In Vitro Anti-leukemic Effect of Wharton’s Jelly Derived Mesenchymal Stem Cells
[Molecular Biology Reports] Wharton’s Jelly-derived-MSCs were isolated from human umbilical cord. The cells were incubated according to the standard culture conditions and characterized by flow cytometry.
Mesenchymal Stromal/Stem Cells Promote Intestinal Epithelium Regeneration after Chemotherapy-Induced Damage
[Stem Cell Research & Therapy] Single cell human small intestine organoids were embedded in Matrigel, grown for five days and treated with busulfan for 48 hours.
rhBMP-2 Induces Terminal Differentiation of Human Bone Marrow Mesenchymal Stromal Cells Only by Synergizing with Other Signals
[Stem Cell Research & Therapy] Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow MSCs were tested in an in vivo subcutaneous implantation model to assess their ability to form mature bone and undergo multilineage differentiation.
Hematopoietic Stem Cell Niche Generation and Maintenance Are Distinguishable by an Epitranscriptomic Program
[Cell] Investigators compared perinatal and adult bone marrow MSCs. MSCs exhibited enrichment in genes mediating m6A mRNA methylation at the perinatal stage and downregulated the expression of Mettl3 shortly after birth.
Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes
[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.
Design of a Stem Cell–Based Therapy for Ependymal Repair in Hydrocephalus Associated with Germinal Matrix Hemorrhages
[Stroke] Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.
Oncogene-Induced Matrix Reorganization Controls CD8+ T Cell Function in the Soft-Tissue Sarcoma Microenvironment
[European Journal Of Clinical Investigation] Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.
Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells
[Advanced Materials] Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.
Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics
[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.
Transcriptomic and Cellular Decoding of Scaffolds-Induced Suture Mesenchyme Regeneration
[International Journal Of Oral Science] Investigators' data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.
Mesenchymal Stem Cells Derived-Exosomes Enhanced Amniotic Membrane Extract Promotes Corneal Keratocyte Proliferation
[Biotechnology Progress] The authors evaluated the effects of both amniotic membrane extract and Wharton's jelly MSC derived-exosomes, individually and together, on the proliferation of corneal keratocytes as well as their ability to promote in vitro cell migration, wound healing, and their impact on cellular morphology.
PPARγ Inhibition Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Fracture Healing
[Journal Of Cellular Biochemistry] Bone healing processes in the rat femur fracture model were recorded and assessed by radiographic methods on Weeks 8, 14, and 20 postoperation.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
