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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Vascular Architecture Regulates Mesenchymal Stromal Cell Heterogeneity via P53-PDGF Signaling in the Mouse Incisor
[Cell Stem Cell] Using adult mouse incisors as a model, scientists uncovered the role of Trp53 in regulating vascular composition through THBS2 to maintain mesenchymal tissue homeostasis.
YTHDF2-Mediated m6A Methylation Inhibition by miR27a as a Protective Mechanism against Hormonal Osteonecrosis in BMSCs
[BMC Musculoskeletal Disorders] Researchers compared miR27a, YTHDF2, and total m6A mRNA levels in steroid-induced necrosis of the femoral head-affected and control bone marrow MSCs. CCK-8 and TUNEL assays were used to assess BMSC proliferation and apoptosis.
MEG3 Shuttled by Exosomes Released from Human Bone Marrow Mesenchymal Stem Cells Promotes TP53 Stability to Regulate MCM5 Transcription in Keloid Fibroblasts
[The Journal of Gene Medicine] Exosomes were isolated from human bone marrow MSCs (hBMSC), and keloid fibroblasts (KFs) were treated with exosomes derived from hBMSC. Cell counting kit-8, wound healing, transwell invasion, immunofluorescence, and western blot assays were conducted to study the malignant phenotype of KFs.
A Composite Hydrogel Functionalized by Borosilicate Bioactive Glasses and VEGF for Critical-Size Bone Regeneration
[Advanced Science] An inorganic–organic multifunctional composite hydrogel denoted as PLG-g-TA/VEGF/Sr-BGNPs was developed, engineered for the synergistic management of bone defects.
WNT5B Drives Osteosarcoma Stemness, Chemoresistance, and Metastasis
[Clinical and Translational Medicine] Using tumor-spheroids to model cancer stem-like cells, investigators performed qPCR, immunoblotting, and immunofluorescence to monitor changes in gene and protein expression.
Regulation of Mitochondrial Network Architecture and Function in Mesenchymal Stem Cells by Micropatterned Surfaces
[Regenerative Biomaterials] Polycaprolactone surfaces were used as models to investigate how micropatterns regulate mitochondrial network architecture and function in rat adipose-derived stem cells.
Root Canal? Next-Gen Treatment Could Involve Stem Cells, Not Surgery
[University at Buffalo] Camila Sabatini, associate professor of restorative dentistry in the School of Dental Medicine at the University at Buffalo, has received the Harold Amos Medical Faculty Development Program award from the Robert Wood Johnson Foundation to study novel therapies to repair damaged teeth.
Pannexins in the Musculoskeletal System: New Targets for Development and Disease Progression
[Bone Research] The authors elucidate the structure of pannexins and their roles in regulating processes such as osteogenesis, chondrogenesis, and muscle growth.
Improved Therapeutic Effects on Vascular Intimal Hyperplasia by Mesenchymal Stem Cells Expressing MIR155HG That Function as a ceRNA for microRNA-205
[Journal of Cellular and Molecular Medicine] Researchers investigated whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of intimal hyperplasia and to elucidate the role of the competing endogenous RNA (ceRNA).
MSCs Promote the Efferocytosis of Large Peritoneal Macrophages to Eliminate Ferroptotic Monocytes/Macrophages in the Injured Endometria
[Stem Cell Research & Therapy] Endometrial injury in intrauterine adhesion mouse model was conducted by uterine curettage and LPS injection surgery and the samples were collected at different times to detect the changes of large peritoneal macrophages and ferroptotic monocytes/macrophages.
HOXB5 Promotes the Progression and Metastasis of Osteosarcoma Cells by Activating the JAK2/STAT3 Signaling Pathway
[Heliyon] The expression of homeobox gene B5 (HOXB5) in human osteosarcoma tissues and its correlation with clinical indicators were investigated using bioinformatics analysis and immunohistochemical labelling.
The Potency of Mesenchymal Stem/Stromal Cells: Does Donor Sex Matter?
[Stem Cell Research & Therapy] The authors summarize published studies demonstrating donor-sex-related MSC heterogeneity and emphasize the importance of disclosing donor sex as a key factor affecting MSC potency in cell therapy.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
