Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Lactylation of mTOR Enhances Autophagy in Skeletal Muscle during Exercise

November 14, 2025

[Cell Chemical Biology] Researchers showed lactate severs as a positive regulator of autophagy in myocytes and its levels increase rapidly in response to a single bout of exercise.

USP13 Ameliorates Diabetic Cardiomyopathy via Deubiquitinating NLRP3 and Inhibiting Pyroptosis in Cardiomyocytes

November 10, 2025

[Cell Death & Differentiation] Scientists observed that the expression of the deubiquitinating enzyme USP13 was significantly downregulated in diabetic cardiomyopathy mouse heart tissues.

YAP1 Reactivation in Cardiomyocytes following ECM Remodelling Contributes to the Development of Contractile Force and Sarcomere Maturation

November 10, 2025

[Cell Death Discovery] The authors employed mechanical actuation as a proxy reproducing extracellular matrix remodelling in vitro to trigger YAP1 nuclear shuttling in contractile cardiomyocytes derived from hESCs and iPSCs.

Hemizygous Mutation of Jmjd3 in Muscle Stem Cells Increases H3K27 Methylation on Pax7 Leading to Impaired Myogenesis

November 10, 2025

[American Journal of Physiology - Cell Physiology] Using sequencing of chromatin fragments precipitated from Jmjd3 mutant and control satellite cells using anti-H3K27me3, researchers found that the Pax7 promoter was the only chromatin that experienced significantly increased H3K27 methylation in mutant cells.

Akt-Axin1/TNKS-Tiam1-Rac1 Mediates Insulin-Stimulated GLUT4 Translocation in Skeletal Muscle Cells

November 10, 2025

[Cellular Signalling] Investigators showed that insulin up-regulated the protein levels of Axin1 and TNKS in an Akt-dependent manner in C2C12 skeletal muscle cells.

Basal Release of 6-Cyanodopamine in Human Vas Deferens, a New Endogenous Catecholamine That Enhances Smooth Muscle Contractility

November 10, 2025

[European Journal of Pharmacology] The authors investigated whether 6-cyanodopamine is released from human epididymal vas deferens and its interaction with the classical catecholamines dopamine, noradrenaline, and adrenaline.

DOT1L Promotes Phenotypic Transition of Vascular Smooth Muscle Cells following Vascular Injury in Diabetes through Activation of the FGFR4/PI3K/AKT/Jag/Notch Signaling Pathway

November 10, 2025

[Cellular Signalling] Using insulin-stimulated rat thoracic aorta vascular smooth muscle cells (VSMCs) and a diabetic rat carotid artery balloon injury model, scientists investigated VSMC proliferation, migration, and collagen synthesis.

Genetic Disruption of Satellite Cell Function Underlying Congenital Myopathies

November 10, 2025

[Journal of Human Genetics] Investigators focus on four genes critical for satellite cell biology: PAX7, MYOD1, MEGF10, and MYMK, and discuss how pathogenic variants in these genes contribute to muscle pathology.

Researcher Earns $2.6 Million to Study the Heartbeat

November 10, 2025

[University of Missouri] Dr. Kerry McDonald recently received a $2.6 million grant from the National Institutes of Health to continue his work studying the mechanisms of the heart, with the ultimate goal of discovering new treatments for heart failure and heart disease.

Delineating Transcriptomic Signatures of In Vitro Human Skeletal Muscle Models in Comparison to In Vivo References

October 27, 2025

[Stem Cell Reports] Scientists delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models and their in vivo counterparts.

Tirzepatide Alleviates Doxorubicin-Induced Cardiotoxicity via Inhibiting HRD1-Mediated Nrf2 Ubiquitination

October 27, 2025

[Cardiovascular Research] Researchers investigated the role of tirzepatide in doxorubicin-induced cardiotoxicity and clarified the underlying mechanisms.

PHB1 Attenuates Triptolide-Induced Cardiotoxicity by Regulating Mitochondrial Dynamics in Cultured Newborn Mice Cardiomyocytes

October 27, 2025

[Journal of Cardiovascular Pharmacology] Investigators found that triptolide (TP) induced mitochondrial dysfunction and apoptosis of cardiomyocytes, which might be the key process underlying TP-induced cardiotoxicity.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.