Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

Lactate and Immunomagnetic-Purified hiPSC-Derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs

[JCI Insight] Scientists determined if use of lactate relative to magnetic antibody-based cell sorting-purified human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes impacted the properties of resulting hiPSC-engineered cardiac tissues.

Dbh+ Catecholaminergic Cardiomyocytes Contribute to the Structure and Function of the Cardiac Conduction System in Murine Heart

[Nature Communications] Investigators reported a previously unrecognised population of cardiomyocytes expressing dopamine beta-hydroxylase (Dbh) gene encoding dopamine beta-hydroxylase in murine heart.

Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects

[Cell] The authors established a human cardioid platform that recapitulated the development of all major embryonic heart compartments, including right and left ventricles, atria, outflow tract, and atrioventricular canal.

TRPV4 Blockade Alleviates Endoplasmic Reticulum Stress Mediated Apoptosis in Hypoxia–Induced Cardiomyocyte Injury

[Cellular Signalling] The ability of transient receptor potential vanilloid 4 (TRPV4) to modulate the endoplasmic reticulum stress and apoptosis was assessed in vitro through the administration of the TRPV4 antagonist HC-067047 or the agonist GSK1016790A.

Oxidative Stress Drives Vascular Smooth Muscle Cell Damage in Acute Stanford Type A Aortic Dissection through HIF-1α/HO-1 Mediated Ferroptosis

[Heliyon] Bioinformatic analyses and experimental validation were performed to reveal ferroptosis and HO-1 expression in acute Stanford type A aortic dissection.

Hallmarks of Aging in Human Skeletal Muscle and Implications for Understanding the Pathophysiology of Sarcopenia in Women and Men

[Clinical Science] Scientists evaluate how the nine classic hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication contribute to skeletal muscle aging and the pathophysiology of sarcopenia.

Foundation Announces $500,000 In New Research Grants

[THE MARFAN FOUNDATION] The Marfan Foundation awarded five new two-year research grants include two Innovator Awards and three Victor McKusick Fellowship Awards. The research projects focus on aortic dissection and thoracic aortic aneurysms.

Serine Synthesis Pathway Enzyme PHGDH Is Critical for Muscle Cell Biomass, Anabolic Metabolism, and mTORC1 Signaling

[American Journal Of Physiology-Endocrinology And Metabolism] Scientists identified enzymes that limited protein synthesis, myotube size, and proliferation in skeletal muscle cells.

Saudi Universities Lose Highly Cited Researchers after Payment Schemes Raise Ethics Concerns

[SCIENCEINSIDER] The number of top researchers affiliated with universities in Saudi Arabia has dropped sharply, months after the institutions were revealed to be enticing eminent scientists abroad to declare a Saudi affiliation—often in exchange for cash—in a bid to boost their rankings.

MicroRNA-92b in the Skeletal Muscle Regulates Exercise Capacity via Modulation of Glucose Metabolism

[Journal Of Cachexia Sarcopenia And Muscle] Adeno-associated virus-mediated skeletal muscle miR-92b overexpression in C57BLKS/J mice, and global knockout of miR-92b mice were used to explore the function of miR-92b in glycogen and lactate metabolism in skeletal muscle.

BACH1 Regulates the Differentiation of Vascular Smooth Muscle Cells from Human Embryonic Stem Cells via CARM1-Mediated Methylation of H3R17

[Cell Reports] Scientists foundnd that the loss of BACH1 in human embryonic stem cells (hESCs) attenuated the expression of vascular smooth muscle cell (VSMC) marker genes, whereas overexpression of BACH1 after mesoderm induction increased the expression of VSMC markers during in vitro hESC-VSMC differentiation.

UC San Diego Researchers Receive Close to $10M from California Stem Cell Research Agency

[UC San Diego] Two researchers at the University of California San Diego received close to $10 million in grants from the California Institute of Regenerative Medicine, the agency announced.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.