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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration
[Circulation] Scientists developed Yes-associated protein (YAP)-K265R and αMHC-MerCreMer; Yap-loxP/K265R mutant mice to examine the pathophysiological role of YAP acetylation in cardiomyocytes during cardiac regeneration.
Exercise-Induced Nrf2 Activation Increases Antioxidant Defenses in Skeletal Muscles
[Free Radical Biology and Medicine] The authors summarize our knowledge about exercise training has influence on the abundance of key antioxidant enzymes in skeletal muscles and provide a state-of-the-art review of the nuclear factor erythroid 2-related factor signaling pathway responsible for many exercise-induced changes in muscle antioxidant capacity.
Wave Life Sciences Receives FDA Rare Pediatric Disease Designation for WVE-N531 for the Treatment of Duchenne Muscular Dystrophy
[Wave Life Sciences, Ltd.] Wave Life Sciences, Ltd. announced that the US FDA has granted Rare Pediatric Disease Designation to WVE-N531 for the treatment of boys with Duchenne muscular dystrophy who are amenable to exon 53 skipping.
Satellite Cell-Derived TRIM28 Is Pivotal for Mechanical Load- and Injury-Induced Myogenesis
[EMBO Reports] Scientists discovered that the myogenic potential of satellite cells required a protein called tripartite motif-containing 28 (TRIM28). The myogenic function of TRIM28 is not dependent on changes in the phosphorylation of its serine 473 residue.
Vinpocetine Alleviates the Abdominal Aortic Aneurysm Progression via VSMCs SIRT1-p21 Signaling Pathway
[Acta Pharmacologica Sinica] Researchers showed that pre-treatment with vinpocetine remarkably prevented aneurysmal dilation and reduced aortic rupture in elastase-induced abdominal aortic aneurysm mice.
LncRNA GHET1 from Bone Mesenchymal Stem Cell–Derived Exosomes Improves Doxorubicin-Induced Pyroptosis of Cardiomyocytes by Mediating NLRP3
[Scientific Reports] The authors found that bone mesenchymal stem cell–derived exosomes could improve doxorubicin-induced cardiotoxicity by inhibiting pyroptosis, but endothelial progenitor cells-derived exosomes couldn’t.
Muscarinic and Nicotinic Receptors Stimulation by Vagus Nerve Stimulation Ameliorates Trastuzumab-Induced Cardiotoxicity via Reducing Programmed Cell Death in Rats
[Toxicology and Applied Pharmacology] Researchers showed that trastuzumab induced cardiac dysfunction by increasing autonomic dysfunction, mitochondrial dysfunction/dynamics imbalance, and cardiomyocyte death including apoptosis, autophagic deficiency, pyroptosis, and ferroptosis, which were notably alleviated by vagus nerve stimulation.
Zfp697 Is an RNA-Binding Protein That Regulates Skeletal Muscle Inflammation and Remodeling
[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that the previously uncharacterized gene and protein Zfp697 was a damage-induced regulator of muscle remodeling. Zfp697/ZNF697 expression was transiently elevated during recovery from muscle atrophy or injury in mice and humans.
EPDR1 Promotes PD-L1 Expression and Tumor Immune Evasion by Inhibiting TRIM21-Dependent Ubiquitylation of IkappaB Kinase-β
[EMBO Journal] Researchers identified ependymin-related protein 1 (EPDR1) as an important tumor-intrinsic regulator of PD-L1 expression and tumor immune evasion.
Remodeling p38 Signaling in Muscle Controls Locomotor Activity via Il-15
[Science Advances] The authors found that exercise activated muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15). IL-15 signaled in the motor cortex, stimulating locomotor activity.
A Primate-Specific Endogenous Retroviral Envelope Protein Sequesters SFRP2 to Regulate Human Cardiomyocyte Development
[Cell Stem Cell] The authors reported a somatic developmental function for the primate-specific ERVH48-1. ERVH48-1 encoded a fragment of a viral envelope that was expressed during early embryonic development.
CD38/cADPR-Mediated Calcium Signaling in a Human Myometrial Smooth Muscle Cell Line, PHM1
[IUBMB Life] Western blot, immunofluorescence, and biochemical studies confirmed CD38 expression and the presence of ADP-ribosyl cyclase and cADPR hydrolase activities on the pregnant human myometrial (PHM1) cell membrane.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
