Muscle Cell News

Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.

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Necessity of Notch3 Signaling in Myofiber Maturation in a Pluripotent Stem Cell Transplant Model

January 14, 2026

[Skeletal Muscle] Since a role for Notch3 in skeletal muscle maturation is unknown, the authors investigated whether Notch3 is required for this in vivo molecular maturation switch.

Inhibition of TREM1 Attenuates Myocardial Ischemia-Reperfusion Injury-Induced Cardiomyocyte Pyroptosis by Suppressing the Activation of the NF-κB Signaling Pathway

January 12, 2026

[PloS One] Scientists investigated the role of TREM-1 in myocardial I/R injury and to explore the potential underlying molecular mechanisms.

Inhibiting L-Type Calcium Channel Promotes Cardiomyocyte Proliferation through Activating the Canonical Wnt Signaling Pathway

January 12, 2026

[Acta Pharmacologica Sinica] Researchers developed a high-content screening assay based on DNA synthesis in human pluripotent stem cell-derived cardiomyocytes (CMs) to identify small molecules that could promote CM proliferation.

Investigating the Role of EGFR Signalling in Muscle Dystrophies: Implications for Duchenne Muscular Dystrophy

January 12, 2026

[Cell Death & Disease] Investigators used datasets from single-nuclei RNA sequencing of Duchenne Muscular Dystrophy muscle samples to study the dysregulation of molecular pathways compared to healthy control muscle.

Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation

January 12, 2026

[Circulation] Enhanced histone lactylation was linked to increased pyruvate dehydrogenase kinase 1 transcription, which accelerated lactate production in vascular smooth muscle cells.

Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension

January 12, 2026

[Circulation Research] Researchers defined the role of adenosine deaminase acting on RNA 1 (ADAR1)-dependent RNA editing in IFNβ activation in pulmonary arterial smooth muscle cells from idiopathic pulmonary arterial hypertension, a devastating disease leading to right heart failure and death.

USP13 Facilitates Pressure Overload Induced Vascular Remodeling and Phenotypic Transition of VSMCs via Deubiquitinating Beclin-1

January 12, 2026

[Cell Death Discovery] Primary vascular smooth muscle cells (VSMCs) were employed to investigate the role of USP13 on VSMC phenotype transition and potential mechanism.

Non-Regenerative Myogenesis in Adult Skeletal Muscles: Myofiber Death-Independent Muscle Satellite Cell Expansion

January 12, 2026

[Skeletal Muscle] The authors introduce the concept and evidence for “non-regenerative myogenesis” in adult skeletal muscle and highlight its characteristics and the remaining research questions.

Biogen Receives European Commission Approval for High Dose Regimen of SPINRAZA® (nusinersen) for Spinal Muscular Atrophy

January 12, 2026

[Biogen, Inc.] Biogen, Inc. announced the European Commission has granted marketing authorization for a high dose regimen of SPINRAZA^®, which is comprised of 50 mg/5 mL and 28 mg/5 mL doses for the treatment of 5q spinal muscular atrophy.

RBFOX2-Dependent Alternative Splicing of Numb Regulates Notch Signaling during Muscle Stem Cell Activation

December 22, 2025

[Stem Cell Reports] Using in vivo fixation to preserve quiescent satellite cells, scientists uncovered rapid and extensive alternative splicing changes upon activation, affecting genes involved in fundamental pathways.

TRPV1 Deletion in Male Mice Alters Cardiomyocyte Ultrastructure without Affecting Baseline Cardiac Function

December 22, 2025

[Scientific Reports] Researchers performed a bibliometric analysis of 331 publications and conducted in vivo and ex vivo cardiac phenotyping of sedentary male TRPV1 knockout and wild-type mice.

Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling

December 8, 2025

[Circulation Research] Scientists investigated whether and how cardiomyocyte NO-sensitive soluble guanylyl cyclase (GC1) mediates female-specific, adaptive right ventricular pressure-overload remodeling.

Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.