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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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Delineating Transcriptomic Signatures of In Vitro Human Skeletal Muscle Models in Comparison to In Vivo References
[Stem Cell Reports] Scientists delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models and their in vivo counterparts.
Tirzepatide Alleviates Doxorubicin-Induced Cardiotoxicity via Inhibiting HRD1-Mediated Nrf2 Ubiquitination
[Cardiovascular Research] Researchers investigated the role of tirzepatide in doxorubicin-induced cardiotoxicity and clarified the underlying mechanisms.
PHB1 Attenuates Triptolide-Induced Cardiotoxicity by Regulating Mitochondrial Dynamics in Cultured Newborn Mice Cardiomyocytes
[Journal of Cardiovascular Pharmacology] Investigators found that triptolide (TP) induced mitochondrial dysfunction and apoptosis of cardiomyocytes, which might be the key process underlying TP-induced cardiotoxicity.
Synthetic Bottlebrush Block Copolymer Prevents Disease Onset in Duchenne Muscular Dystrophy
[Proceedings of the National Academy of Sciences of the United States of America] Data showed the remarkable potency of a synthetic poly(ethylene oxide)/poly(propylene oxide) side chain–based bottlebrush block copolymer, ~150,000 times more potent than linear polymers, to rapidly restore contractile function to Duchenne muscular dystrophy skeletal muscle fibers in vitro.
YY1 Regulates Vascular Resistance and Blood Pressure Dynamics through Epigenetic Control of m6a RNA Modifications in Vascular Smooth Muscle Cells
[Cardiovascular Research] The authors hypothesized that YY1, a transcription factor, facilitated vascular function by epigenetically regulating gene expression in vascular smooth muscle cells.
PRDM16 Regulates Smooth Muscle Cell Identity and Atherosclerotic Plaque Composition
[Nature Cardiovascular Research] Researchers identified PRDM16, a gene linked to cardiovascular disease, as a critical transcriptional repressor of the synthetic smooth muscle cell phenotype.
Endothelial-Smooth Muscle Microgauges for Modeling Pulmonary Arterial Vasoregulation
[Lab on a Chip] Scientists microfabricated pulmonary artery smooth muscle (PASMC) microgauges that enabled quantification of contractile forces generated by human PASMCs within microtissues that contain a functional monolayer of pulmonary arterial endothelial cells.
Uremic Serum Exposure Leads to Differential Phenotypic Switch in Porcine Arterial and Venous Smooth Muscle Cells
[American Journal of Physiology-Renal Physiology] To investigate the underlying mechanisms, scientists used porcine-derived arterial smooth muscle cells and venous smooth muscle cells to examine several key aspects of cell behavior in response to uremic serum.
Role of Lipid Droplets in Pulmonary Arterial Hypertension: Focusing on Pulmonary Artery Smooth Muscle Cell Proliferation
[Lipids in Health and Disease] The authors investigate the role of lipid droplets in pulmonary arterial hypertension by focusing on the proliferation of pulmonary artery smooth muscle cells.
Muscular Dystrophy Association Advocates to Congress on November 4: Every Moment Matters in the Fight Against Muscle Loss
[ Muscular Dystrophy Association] The Muscular Dystrophy Association (MDA) will bring nearly 100 advocates, scientists, and families living with neuromuscular diseases to Capitol Hill for MDA on the Hill, meeting with members of Congress to urge action on critical federal policies that impact access to care, research progress, and support for families.
Muscle Organoids Reveal Exercise-Like Contractions Rapidly Promote Muscle Health via Lamtor1’S Signaling to Both AMPK and mTOR
Researchers differentiated human embryonic stem cells into induced skeletal muscle (iMusc) cells to identify hypertrophic factors and generates a novel 3D human iMusc organoid...
Specific Induction of Right Ventricular-Like Cardiomyocytes from Human Pluripotent Stem Cells
Scientists established a methodology to generate right ventricle-like human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) to support the development of disease modeling research using chamber-specific...
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
