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Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
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RBFOX2-Dependent Alternative Splicing of Numb Regulates Notch Signaling during Muscle Stem Cell Activation
[Stem Cell Reports] Using in vivo fixation to preserve quiescent satellite cells, scientists uncovered rapid and extensive alternative splicing changes upon activation, affecting genes involved in fundamental pathways.
TRPV1 Deletion in Male Mice Alters Cardiomyocyte Ultrastructure without Affecting Baseline Cardiac Function
[Scientific Reports] Researchers performed a bibliometric analysis of 331 publications and conducted in vivo and ex vivo cardiac phenotyping of sedentary male TRPV1 knockout and wild-type mice.
Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling
[Circulation Research] Scientists investigated whether and how cardiomyocyte NO-sensitive soluble guanylyl cyclase (GC1) mediates female-specific, adaptive right ventricular pressure-overload remodeling.
Succinate-GPR91 Signaling Promotes Cardiomyocyte Metabolic Reprogramming and NAD+ Production to Alleviate HFpEF
[Cardiovascular Diabetology] Investigators identified the succinate–GPR91 axis as a critical regulator of cardiometabolic homeostasis and a potential therapeutic target in heart failure with preserved ejection fraction (HFpEF).
Displaced Myonuclei Are Attributable to Both Resident Myonuclear Migration and Stem Cell Fusion during Mechanical Loading in Adult Skeletal Muscle
[Skeletal Muscle] Scientists investigated whether displaced myonuclei in adult skeletal muscle originate exclusively from an exogenous source, such as satellite cells, or can result from resident myonuclear migration.
Defective Vascular Smooth Muscle Cell Tafazzin Impairs Mitochondrial Function and Promotes Atherosclerosis in Preclinical Models
[Nature Communications] Researchers showed that tafazzin expression is decreased in atherosclerotic lesions and specifically in plaque vascular smooth muscle cells.
Remodelling of the Endothelial Extracellular Matrix Promotes Smooth Muscle Cell Hyperplasia in Pulmonary Hypertension Due to Left Heart Disease
[Cardiovascular Research] The authors investigated the role of the endothelial extracellular matrix, specifically the pulmonary arterial basement membrane, in influencing smooth muscle cell proliferation and phenotypic changes in pulmonary hypertension secondary to left heart disease.
Long-Acting β Agonist (LABA) with a Long-Acting Muscarinic Receptor Antagonist (LAMA) Promotes Human Airway Smooth Muscle (HASM) Relaxation and Circumvents β Adrenergic Receptor Tachyphylaxis
[Respiratory Research] Scientists hypothesized that LABA/LAMA therapy is more effective in attenuating excitation-contraction coupling compared to either LAMA or LABA alone in human airway smooth muscle cells.
Precision Rewriting of Muscle Genetics: Therapeutic Horizons of Base and Prime Editing in Skeletal Muscle Disorders
[Gene Therapy] The authors explore mechanisms of base editing and prime editing and summarize their current applications in monogenic skeletal muscle disorders.
RESTEM Announces First-Patient-Dosed in the Phase I/IIa Study of Restem-L in Facioscapulohumeral Muscular Dystrophy
[RESTEM (Globe Newswire)] RESTEM announced the initiation of a Phase I/IIa study of Restem-L, the company’s umbilical lining modified progenitor cells off-the-shelf platform, for the treatment of facioscapulohumeral muscular dystrophy.
Calcitonin Receptor Downregulation and Exercise-Conditioned Blood Enable Systemic Muscle Stem Cell Proliferation
[Nature Communications] Researchers found that increased loading reduces calcitonin receptor (CalcR) expression, and forced activation of protein kinase A, a downstream of CalcR signaling, suppresses muscle stem cell proliferation.
Transient Overexpression of hPKM2 in Porcine Cardiomyocytes Prevents Heart Failure after Myocardial Infarction
[Nature Communications] Researchers used a targeted, non-viral modified mRNA system to transiently boost expression of a regenerative enzyme, pyruvate kinase muscle isozyme M2, in heart muscle cells of juvenile and adult pig models after ischemic injury.
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
