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Muscle Cell News
Muscle Cell News is an online resource dedicated to the latest research into smooth, skeletal, and cardiac muscle cells.
METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy
[Circulation] Cardiomyocyte-specific N6-adenosine-methyltransferase-like 3 (METTL3) knockout mice and their wild-type littermates were subjected to either chow diet or high-fat diet feeding and injection of streptozotocin to induce diabetic cardiomyopathy.
Dusp14-Mediated Dephosphorylation of MLKL Protects against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure
[Circulation] Dual specificity phosphatase 14 (Dusp14) knockout mice were generated, and adeno-associated virus–mediated cardiomyocyte-specific overexpression of Dusp14 was used in combination with related cellular experiments to investigate the protective effects of Dusp14 on hypothyroidism-induced heart failure.
Nicotinamide Riboside Promoted Cardiac Energetics and Alleviated Doxorubicin-Induced Cardiotoxicity via SIRT1/ERRα Signal in Human Pluripotent Stem Cells-Derived Cardiomyocytes
[Life Sciences] Investigators tested the role and mechanism of nicotinamide ribose on hiPSC-differentiated cardiomyocytes under normal and doxorubicin-treated states.
KrüPpel like Factor 7 Regulates Mitochondrial Dynamics Balance in Myocardial Infarction
[Communications Biology] The authors generated cardiomyocyte-specific Klf7 knockout and overexpression mice that underwent myocardial infarction surgery.
Fatty Acid Metabolism Suppresses Neonatal Cardiomyocyte Proliferation by Increasing PDK4 and HMGCS2 Expression through PPARδ
[PLOS One] Scientists investigated how fatty acid metabolism contributes to cell cycle regulation in neonatal cardiomyocytes. Cultured neonatal rat cardiomyocytes were treated with a fatty acid mixture consisting of palmitic and oleic acids containing L-carnitine.
Cancer-Induced FOXP1 Disrupts and Reprograms Skeletal-Muscle Circadian Transcription in Cachexia
[Cell Reports] Investigators identified forkhead box P1 (FoxP1) as a key disruptor of the skeletal-muscle clock in response to cancer that reprograms circadian patterns of gene expression at cachexia onset.
Rhythmic Insulin Induced by Eating During the Active Phase Promotes Skeletal Muscle Growth via Synchronizing Mitochondrial Energy Supply Rhythm and Cell Cycle
[FASEB Journal] Nocturnal rabbits were subjected to day-restricted feeding (DRF) and night-restricted feeding (NRF), and it was found that DRF disrupts insulin rhythm, whereas NRF enhances insulin rhythm and promotes skeletal muscle growth.
Adrenergic Modulation of Acetylcholine Release at the Mouse Neuromuscular Junctions of Fast-Twitch Skeletal Muscle
[Neurochemical Research] Researchers presented experimental data on neurotransmitter release modulation by adrenergic ligands at the neuromuscular junctions of mouse fast-twitch skeletal muscle levator auris longus.
LONP1 Facilitates Pulmonary Artery Smooth Muscle Cell Glycolytic Reprogramming by Degrading MPC1 in Pulmonary Hypertension
[Clinical Science] Su5416/hypoxia-induced and monocrotaline-induced pulmonary hypertension (PH) rodent models and platelet-derived growth factor BB-induced pulmonary artery smooth muscle cells were used to investigate the role and mechanism of lon protease 1 (LONP1) in PH.
Effects and Mechanisms of Trifolin on Attenuating Hypertension-Induced Vascular Smooth Muscle Cell Proliferation and Collagen Deposition In Vivo and In Vitro
[Scientific Reports] Scientists investigated trifolin’s potential therapeutic effects and underlying mechanisms of action on angiotensin II (Ang II)-induced hypertension in mice and Ang II stimulated A7R5 cells.
Insights into Human Muscle Biology from Human Primary Skeletal Muscle Cell Culture
[Journal of Muscle Research and Cell Motility] The authors highlight the multitude of muscle biology that has been investigated using human primary cells, as well as discussing the advantages and disadvantages over other cell models.
SOLVE FSHD Announces $3 Million Investment in Armatus Bio to Advance Gene Therapy Program for FSHD
[SOLVE FSHD] SOLVE FSHD announced a $3 million investment in Armatus Bio. The investment will support ARM-201, Armatus Bio’s AAV-delivered microRNA therapy designed to silence the expression of DUX4, the toxic protein responsible for muscle degeneration in individuals with facioscapulohumeral muscular dystrophy (FSHD).
Every day, our editorial team sifts through the most recent scientific literature to help keep researchers and medical professionals current. Muscle Cell News covers the three types of muscle cells: cardiac, skeletal, and smooth muscle. We cover a broad range of topics, including cell culturing, muscle regeneration, and musculoskeletal disorders.
