Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

Subscribe|Follow Us On

PHF2 Regulates Genome Topology and DNA Replication in Neural Stem Cells via Cohesin

May 31, 2024

[Nucleic Acids Research] Investigators discovered that the histone demethylase PHF2 associated with RAD21, a core subunit of cohesin, to regulate DNA replication in mouse neural stem cells.

Variant-Specific Pathophysiological Mechanisms of AFF3 Differently Influence Transcriptome Profiles

May 31, 2024

[Genome Medicine] Researchers screened ID cohorts for individuals with predicted-to-be damaging variants in AFF3. They used both animal and cellular models to assess the deleteriousness of the identified variants.

Brain Cell-Type Shifts in Alzheimer’s Disease, Autism, and Schizophrenia Interrogated Using Methylomics and Genetics

May 30, 2024

[Science Advances] Researchers observed and replicated cell-type compositional shifts for Alzheimer’s disease, autism, and schizophrenia, and find age- and sex-related changes.

MGMT Inhibition Regulates Radioresponse in GBM, GSC, and Melanoma

May 29, 2024

[Scientific Reports] Investigators evaluated whether O6-methylguanine-DNA methyltransferase (MGMT) expression affected the radioresponse of human glioblastoma (GBM), GBM stem-like cells, and melanoma. They reported a correlation between MGMT promoter methylation status and MGMT expression.

Microglia, Trem2, and Neurodegeneration

May 29, 2024

[Neuroscientist] The authors highlight the promise of Trem2 as a therapeutic target, especially for Aβ-associated Alzheimer disease, and calls for more mechanistic investigations to understand the context-specific role of microglial Trem2 in developing effective therapies against neurodegenerative diseases.

Autistic People Three Times More Likely to Develop Parkinson’s-Like Symptoms

May 29, 2024

[Nature News] A study of quarter of a million people with autism, intellectual disabilities or both has found that their risk of developing symptoms associated with Parkinson’s disease is three times that in the general population.

FUDNC1-Dependent Mitophagy Ameliorate Motor Neuron Death in an Amyotrophic Lateral Sclerosis Mouse Model

May 28, 2024

[Neurobiology of Disease] The authors observed that FUNDC1 was significantly downregulated in the spinal cord tissues of SOD1G93A mice. FUNDC1 overexpression considerably improved locomotor activity and prolonged survival time in SOD1G93A mice.

NG2 Glia Protect Against Prion Neurotoxicity by Inhibiting Microglia-to-Neuron Prostaglandin E2 Signaling

May 28, 2024

[Nature Neuroscience] Loss of NG2 glia enhanced the biosynthesis of prostaglandin E2 (PGE2) by microglia, which augmented prion neurotoxicity through binding to the EP4 receptor.

Glioblastoma Disrupts Cortical Network Activity at Multiple Spatial and Temporal Scales

May 28, 2024

[Nature Communications] Researchers combined cellular and widefield imaging of calcium and glutamate fluorescent reporters in two glioblastoma mouse models with distinct synaptic microenvironments and infiltration profiles.

Micropeptide AF127577.4-ORF Hidden in a lncRNA Diminishes Glioblastoma Cell Proliferation via the Modulation of ERK2/METTL3 Interaction

May 28, 2024

[Scientific Reports] The authors identified and characterized a novel hidden micropeptide implicated in glioblastoma. They screened potential candidate lncRNAs by establishing a workflow involving ribosome-bound lncRNAs, publicly available MS/MS data, and prognosis-related lncRNAs.

Macroscopic Changes in Aquaporin-4 Underlie Blast Traumatic Brain Injury-Related Impairment in Glymphatic Function

May 28, 2024

[Brain] Scientists examined the expression and localization of AQP4 in human post-mortem frontal cortex and observed distinct laminar differences in AQP4 expression following blast exposure.

IRLAB Has Administered the First Dose in a Phase I Clinical Trial with the Drug Candidate IRL757

May 22, 2024

[IRLAB Therapeutics] IRLAB Therapeutics AB announced that dosing has been initiated in a Phase I study of the drug candidate IRL757. IRL757 has been shown in preclinical disease models to counteract apathy – a condition that impairs the quality of life for millions of people with Parkinson’s disease and other CNS diseases.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.