Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Restoration of Striatal Neuroprotective Pathways by Kinase Inhibitor Treatment of Parkinson’S Disease-Linked LRRK2-Mutant Mice

July 2, 2025

[Science Signaling] Researchers tested the leucine-rich repeat kinase 2 (LRRK2) inhibitor MLi-2 in a mouse model of early stage, LRRK2 mutation–associated Parkinson's disease.

Glial Reactivity Correlates with Synaptic Dysfunction across Aging and Alzheimer’s Disease

July 2, 2025

[Nature Communications] Scientists investigated the association between glial reactivity and synaptic dysfunction biomarkers in cerebrospinal fluid from 478 individuals in cognitively unimpaired and cognitively impaired individuals.

HDL-Bound S1P Affects the Subventricular Niche and Early Neuropathological Features of Alzheimer’s Disease

July 2, 2025

[Nature Communications] Using apolipoprotein M (Apom)^-/- mice, scientists showed that blood ApoM-sphingosine-1-phosphate (S1P) deficiency impairs the subventricular zone-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow.

Connexin43 Hemichannel Blockade Turns Microglia Neuroprotective and Mitigates Cognitive Deficits in a Mouse Model of Amyloidosis

July 2, 2025

[Nature Communications] Researchers identified microglial connexin43 hemichannels as a regulator of microglial reactivity in Alzheimer's disease, positioning them as a promising therapeutic target.

Distinct Dendritic Integration Strategies Control Dynamics of Inhibition in the Neocortex

July 2, 2025

[Neuron] Investigators found that the two major cortical interneuron subtypes—somatostatin- and parvalbumin-expressing cells—use distinct strategies for distributing and integrating excitatory synaptic inputs along their dendrites.

A Unifying Mechanism for Presynaptic Homeostatic Plasticity at Mammalian Peripheral and Central Synapses

July 2, 2025

[Neuron] Researchers defined secreted class III semaphorin as a unifying, trans-synaptic signal necessary for presynaptic homeostatic plasticity at highly divergent synapses.

LHX2 Regulates Dendritic Morphogenesis in Layer II/III Neurons of the Neocortex

July 2, 2025

[Science Advances] Scientists investigated mechanisms regulating dendritic arbors and spines of callosal neurons.

Hope for Brain Cancer: FAU Awarded Grants for Glioblastoma Treatment

July 2, 2025

[Florida Atlantic University] Florida Atlantic University (FAU) researchers have secured two key grants to investigate targeting a gene for the first time as a new approach to treat glioblastoma

Alan Evans Receives Order of Canada

July 2, 2025

[McGill University] Dr. Alan Evans, Distinguished James McGill Professor of Neurology and Neurosurgery and Psychiatry at McGill University and neuroscientist at The Neuro, has been named one of this year’s Order of Canada recipients by the office of Her Excellency the Right Honourable Mary Simon, Governor General of Canada.

Engrafted Nitrergic Neurons Derived from hPSCs Improve Gut Dysmotility in Mice

June 26, 2025

[Nature] Scientists introduced a platform based on hPSCs for therapeutic development targeting gastrointestinal motility disorders.

Cholinergic Basal Forebrain Neurons Regulate Vascular Dynamics and Cerebrospinal Fluid Flux

June 26, 2025

[Nature Communications] Investigators demonstrated that cholinergic neurons modulate blood oxygenation level-dependent-cerebrospinal fluid coupling and glymphatic function.

An Organ-Chip Model of Sporadic ALS Using iPSC-Derived Spinal Cord Motor Neurons and an Integrated Blood-Brain-Like Barrier

June 26, 2025

[Cell Stem Cell] The authors combined motor neurons from patients with early-onset disease with brain microvascular endothelial-like cells in a microfluidic device and added media flow, which enhances neuronal maturation and improved cellular health.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.