Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

Scientists used 2D and 3D human brain cultures to investigate methyl-CpG binding protein 2 (MeCP2) function. They found that MeCP2 mutations caused severe abnormalities in human interneurons.
[Molecular Cell]
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons: Molecular Cell. (n.d.). Retrieved June 12, 2020, from https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30317-8 Cite
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Toxoplasma gondii Infection Impairs Radial Glia Differentiation and Its Potential to Modulate Brain Microvascular Endothelial Cell Function in the Cerebral Cortex

Conditioned medium (CM) from Radial Glia (RG) control cultures increased ZO-1 protein levels and organization on endothelial bEnd.3 cells membranes, which was impaired by CM from infected RG, accompanied by decreased trans-endothelial electrical resistance.
[Microvascular Research]
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Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons

Researchers used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections.
[Scientific Reports]
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Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]
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Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury

Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine]
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Dual Role of WISP1 in Maintaining Glioma Stem Cells and Tumor-Supportive Macrophages in Glioblastoma

Researchers showed that glioma stem cells (GSCs) secreted the Wnt‐induced signaling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both GSCs and tumor-associated macrophages.
[Nature Communications]
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A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Scientists unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons.
[Cell Reports]
A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum: Cell Reports. (n.d.). Retrieved June 4, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30673-2 Cite
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Dilp-2-Mediated PI3-Kinase Activation Coordinates Reactivation of Quiescent Neuroblasts with Growth of Their Glial Stem Cell Niche

Investigators found that Drosophila insulin-like peptide (Dilp)-2 was required for PI3-kinase activation and growth coordination between neuroblasts and glia in the brain.
[PLoS Biology]
Dilp-2–mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche. (n.d.). Retrieved June 4, 2020, from https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000721 Cite
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Brain Organoids: An Ensemble of Bioassays to Investigate Human Neurodevelopment and Disease

The authors summarize how the diverse brain organoid methods can be utilized to enhance our understanding of brain disorders.
[Cell Death and Differentiation]
Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease | Cell Death & Differentiation. (n.d.). Retrieved June 4, 2020, from https://www.nature.com/articles/s41418-020-0566-4 Cite
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Nascent Biotech to Begin Phase I Human Trials for Brain Cancer Drug

Nascent Biotech, Inc. announced that the company will soon begin Phase I clinical trials for a treatment of brain cancer, including, glioblastoma, the deadliest form of brain cancer.
[Nascent Biotech]
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The Pandemic Is Challenging China’s Breakneck Race to the Top of Science

When COVID-19 hit, China was close to surpassing the United States as the leading science funder, two years after it took top place as the biggest producer of scientific articles. And the country has boosted science around the world by supplying other regions with graduate students and postdoctoral scholars, who now number in the hundreds of thousands a year.
[Nature News]
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