Rebound Growth of BRAF Mutant Pediatric Glioma Cells after MAPKi Withdrawal is Associated with MAPK Reactivation and Secretion of Microglia-Recruiting Cytokines

Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.