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    2022-01-24 | MUSCN 7.02


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.02 – 24 January, 2022
    TOP STORY

    Enrichment of the Exocytosis Protein STX4 in Skeletal Muscle Remediates Peripheral Insulin Resistance and Alters Mitochondrial Dynamics via Drp1

    Researchers showed that transgenic skeletal muscle-specific syntaxin 4 (STX4) enrichment in mice reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation

    During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell could both experience significant changes over time.
    [PLoS Genetics]

    Full Article

    LncRNA ROR Modulates Myocardial Ischemia-Reperfusion Injury Mediated by the miR-185-5p/CDK6 Axis

    Researchers revealed that hypoxia/reoxygenation treated human cardiac myocytes showed a significantly decreased miR-185-5p expression and increased expression of CDK6 and ROR.
    [Laboratory Investigation]

    Abstract

    Overexpression of the SARS-CoV-2 Receptor Angiotensin Converting Enzyme 2 in Cardiomyocytes of Failing Hearts

    Scientists examined the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure.
    [Scientific Reports]

    Full Article

    Lycium barbarum Polysaccharide Antagonizes Cardiomyocyte Apoptosis by Inhibiting the Upregulation of GRK2 Induced by I/R Injury, and Salvage Mitochondrial Fission/Fusion Imbalance and AKT/eNOS Signaling

    Investigators found that Lycium barbarum polysaccharide limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress.
    [Cellular Signalling]

    Abstract

    Nampt Activator P7C3 Ameliorates Diabetes and Improves Skeletal Muscle Function Modulating Cell Metabolism and Lipid Mediators

    Researchers assessed the functional, morphometric, biochemical, and molecular effects of P7C3 treatment in skeletal muscle of type 2 diabetic mice.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    Ca2+ Leak through Ryanodine Receptor 1 Regulates Thermogenesis in Resting Skeletal Muscle

    By inhibiting a subpopulation of ryanodine receptor 1 (RyR1)s in a single-fiber preparation via targeted delivery of ryanodine through transverse tubules, scientists achieved in-preparation isolation of RyR1 Ca2+ leak.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Role of Smooth Muscle Activation in the Static and Dynamic Mechanical Characterization of Human Aortas

    Scientists illustrated the importance of vascular smooth muscle activation for the static and dynamic mechanical response of human aortas.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The MFF-SIRT1/3 Axis, Regulated by miR-340-5p, Restores Mitochondrial Homeostasis of Hypoxia-Induced Pulmonary Artery Smooth Muscle Cells

    Pulmonary artery smooth muscle cells were cultured in hypoxia condition for constructing a pulmonary arterial hypertension model in vitro. The expression of genes and proteins were determined by qRT-PCR and western bolt assays.
    [Laboratory Investigation]

    Full Article

    Phosphodiesterase 4D Promotes Angiotensin II-Induced Hypertension in Mice via Smooth Muscle Cell Contraction

    Researchers revealed that phosphodiesterase 4D expression was upregulated in the aortas of experimental hypertension induced by angiotensin II.
    [Communications Biology]

    Full Article

    Upregulation of TGF-β Type II Receptor in High Glucose-Induced Vascular Smooth Muscle Cells

    Scientists investigated the effects of high-glucose conditions on TGF-β type II receptor expression levels, cell viability, and migration rate in vascular smooth muscle cells.
    [Molecular Biology Reports]

    Abstract

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    REVIEWS

    Epigenetic Control of Muscle Stem Cells: Time for a New Dimension

    Scientists review the current knowledge on the epigenetic dynamics that allow muscle stem cell’s fate decisions.
    [Trends in Genetics]

    Abstract

    INDUSTRY AND POLICY NEWS

    Venus Concept Receives FDA 510(k) Clearance of Venus BlissMAX for Non-invasive Lipolysis of the Abdomen and Flanks, Cellulite Reduction and Muscle Conditioning

    Venus Concept Inc. announced that it has received 510(k) clearance from the US FDA to market the Venus BlissMAX device in the United States.
    [Venus Concept Inc. (GlobeNewswire, Inc.)]

    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
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    JOB OPPORTUNITIES

    Full Professor – Neuropaediatrics

    University of Tübingen – Tübingen, Germany

    Research Scientist – Cardiobiology

    Ksilink – Strasbourg, France

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    Ume̴ University РUme̴, Sweden

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Scientist – Epigenetics of Aging

    RWTH Aachen Medical School – Aachen, Germany

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