 | | Vol. 14.42 – 2 December, 2022 |
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| The authors analyzed patients and mice with germline STAT3 gain-of-function (GOF) mutations, finding that these mutations drove the accumulation of effector CD8+ T cell clones highly expressing the NKG2D receptor.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that NLR family pyrin domain containing protein 3 (NLRP3) inflammasome activators primarily converged on disruption of endoplasmic reticulum–endosome membrane contact sites.
[Nature Immunology] |
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| Single-cell RNA sequencing in a murine model of Still’s disease showed preferential activation of mechanistic target of rapamycin complex 1 (mTORC1) in monocytes; both mTOR inhibition and monocyte depletion attenuated disease severity.
[Nature Communications] |
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| Mice with myeloid-specific G-protein-signaling modulator 1 (GPSM1) ablation were protected against high fat diet-induced insulin resistance, glucose dysregulation, and liver steatosis via repression of adipose tissue pro-inflammatory states.
[Nature Communications] |
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| Researchers showed that, following vaccination with a replication-deficient strain of Toxoplasma gondii, CD8+ T cell expression of T-bet was required for optimal expansion of parasite-specific effector CD8+ T cells.
[Journal of Experimental Medicine] |
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| Deficiency of Lamtor1, an essential component of the Ragulator complex, abrogated NLRP3 inflammasome activation in murine macrophages and human monocytic cells.
[EMBO Journal] |
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| Using novel polychromic mice to achieve higher phenotypic resolution, scientists have characterized bone marrow progenitors that were committed to the group 1 ILC lineage.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Mechanistically, antigen-presenting T cells provided co-stimulation through an unconventional mechanism, acquiring B7 molecules via CD28-dependent trogocytosis from B7-expressing thymic epithelial cells, dendritic cells, and B cells.
[Cell Reports] |
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| Exosomes could be administered for the treatment of rheumatoid arthritis, by acting as therapeutic vectors. Exosomes are murine extracellular vesicles that influence biological mechanisms and signal transduction by transporting genetic and protein components.
[Inflammopharmacology] |
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| The Gary S. Gilkeson Career Development Award was designed for fellows and clinicians with the goal of supporting early career scientists and providing mentorship during a critical time in their lupus research career.
[Lupus Foundation of America] |
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| February 15 – 17, 2022
Lorne, Victoria, Australia |
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| | Lund University – Lund, Sweden |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | AstraZeneca – Gothenburg, Sweden OR Gaithersburg or Wilmington, United States |
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| | University of Oxford – Oxford, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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