 | | Vol. 14.40 – 25 October, 2023 |
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| Investigators explored the expression, function, and mechanism of AZGP1P2, a pseudogene of AZGP1, in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer.
[Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a CD44 antibody modified iridium nanosheet with enzyme-like activity that effectively eradicated CSCs for cancer therapy.
[Acta Biomaterialia] |
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| Scientists provided evidence that a novel hypoxia-specific circSTT3A is significantly upregulated in clinical breast cancer (BC) tissues, and was closely related to the clinical stage and poor prognosis of patients with BC.
[Pharmacological Research] |
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| Using samples from patients with colorectal cancer (CRC), mouse models of KrasG12D and BrafV600E CRC, and a Zeb1-deficient mouse, we show that ZEB1 had opposite functions in KRAS- and BRAF-mutant CRCs.
[JCI Insight] |
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| Researchers found that low serum interferon-γ (IFN-γ) levels correlated with a higher percentage of leukemia stem cell and greater relapse incidence in AML patients.
[Oncogene] |
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| Scientists established two study models to specifically determine the effects of cardiac glycosides on leukemic stem cells (LSC) death and differentiation—one allowed change in dynamics of LSCs and leukemic progenitor cells, while another maintained their undifferentiated status.
[Cell Communication And Signaling] |
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| The authors found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of Natural Killer (NK) cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.
[Scientific Reports] |
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| Researchers found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.
[Scientific Reports] |
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| Scientists investigated the antitumor effect of berbamine, extracted from berberis amurensis, on prostate cancer stem cells.
[The Prostate] |
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| The maintenance of CSC characteristics plays a pivotal role in driving CSC-associated tumor metastasis and conferring resistance to therapy. Consequently, CSCs have emerged as promising targets in cancer treatment.
[Molecular Cancer] |
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| Increasing evidence indicated that specific biomarkers, aberrant activated pathways, immunosuppressive tumor microenvironment (TME), and immunoevasion are considered the culprits in the occurrence of CSCs and the maintenance of CSCs properties including multi-directional differentiation.
[Molecular Cancer] |
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| Immunotherapy pioneer Dr. Steven A. Rosenberg has been awarded the National Medal of Technology and Innovation by President Biden. It is the nation’s highest honor for technological achievement.
[National Institutes of Health] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | University of Gothenburg – Gothenburg, Sweden |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
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