Cancer Stem Cell New Volume 14.40 | Oct 25 2023

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    2024-10-25 | CSCN 14.40


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 14.40 – 25 October, 2023
    TOP STORY

    AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification

    Investigators explored the expression, function, and mechanism of AZGP1P2, a pseudogene of AZGP1, in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer.
    [Research]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Iridium Nanozyme-Mediated Photoacoustic Imaging-Guided NIR-II Photothermal Therapy and Tumor Microenvironment Regulation for Targeted Eradication of Cancer Stem Cells

    The authors developed a CD44 antibody modified iridium nanosheet with enzyme-like activity that effectively eradicated CSCs for cancer therapy.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    Hypoxia-Induced circSTT3A Enhances Serine Synthesis and Promotes H3K4me3 Modification to Facilitate Breast Cancer Stem Cell Formation

    Scientists provided evidence that a novel hypoxia-specific circSTT3A is significantly upregulated in clinical breast cancer (BC) tissues, and was closely related to the clinical stage and poor prognosis of patients with BC.
    [Pharmacological Research]

    Full ArticleGraphical Abstract

    The EMT Factor ZEB1 Paradoxically Inhibits EMT in BRAF-Mutant Carcinomas

    Using samples from patients with colorectal cancer (CRC), mouse models of KrasG12D and BrafV600E CRC, and a Zeb1-deficient mouse, we show that ZEB1 had opposite functions in KRAS- and BRAF-mutant CRCs.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Low Doses of IFN-γ Maintain Self-Renewal of Leukemia Stem Cells in Acute Myeloid Leukemia

    Researchers found that low serum interferon-γ (IFN-γ) levels correlated with a higher percentage of leukemia stem cell and greater relapse incidence in AML patients.
    [Oncogene]

    Abstract

    Cardiac Glycoside Ouabain Efficiently Targets Leukemic Stem Cell Apoptotic Machinery Independent of Cell Differentiation Status

    Scientists established two study models to specifically determine the effects of cardiac glycosides on leukemic stem cells (LSC) death and differentiation—one allowed change in dynamics of LSCs and leukemic progenitor cells, while another maintained their undifferentiated status.
    [Cell Communication And Signaling]

    Full Article

    Identification of ONECUT3 as a Stemness-Related Transcription Factor Regulating NK Cell-Mediated Immune Evasion in Pancreatic Cancer

    The authors found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of Natural Killer (NK) cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.
    [Scientific Reports]

    Full Article

    Identification of ONECUT3 as a Stemness-Related Transcription Factor Regulating NK Cell-Mediated Immune Evasion in Pancreatic Cancer

    Researchers found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.
    [Scientific Reports]

    Full Article

    Berbamine Targets Cancer Stem Cells and Reverses Cabazitaxel Resistance via Inhibiting IGF2BP1 and P-STAT3 in Prostate Cancer

    Scientists investigated the antitumor effect of berbamine, extracted from berberis amurensis, on prostate cancer stem cells.
    [The Prostate]

    Full Article
    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    REVIEWS

    Regulation and Signaling Pathways in Cancer Stem Cells: Implications for Targeted Therapy for Cancer

    The maintenance of CSC characteristics plays a pivotal role in driving CSC-associated tumor metastasis and conferring resistance to therapy. Consequently, CSCs have emerged as promising targets in cancer treatment.
    [Molecular Cancer]

    Full Article

    The Strategies to Cure Cancer Patients by Eradicating Cancer Stem-Like Cells

    Increasing evidence indicated that specific biomarkers, aberrant activated pathways, immunosuppressive tumor microenvironment (TME), and immunoevasion are considered the culprits in the occurrence of CSCs and the maintenance of CSCs properties including multi-directional differentiation.
    [Molecular Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Immunotherapy Pioneer Steven Rosenberg Awarded Nation’s Highest Honor for Technology and Innovation

    Immunotherapy pioneer Dr. Steven A. Rosenberg has been awarded the National Medal of Technology and Innovation by President Biden. It is the nation’s highest honor for technological achievement.
    [National Institutes of Health]

    Press Release
    FEATURED EVENT

    Donor Selection & Cell Source Summit

    November 28 – 30, 2023
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Immunology, Immunotherapy & Cancer Metastasis

    University of Notre Dame – Notre Dame, Indiana, United States

    Researcher – Tumors and Pre-Cancers

    Stanford Medicine – Stanford, California, United States

    Postdoctoral Research Fellow – Pancreatic Cancer Metabolism

    University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

    Postdoctoral Scientist – Skin Cancer and Aging

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    Postdoctoral Fellow – Cancer Research

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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