Cancer Stem Cell News Volume 10.00 | Jan 6 2021

2021-01-06 | 10.01

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.00 – 6 January, 2021

Fate-Switches in Stem-Like Cells Drive the Tumorigenic Trajectory from Human Neural Stem Cells to Malignant Glioma

Researchers established two highly penetrant human neural stem cell-derived malignant glioma models, which resembled the histopathology and transcriptional heterogeneity of human glioblastoma.
[Cell Research]

Full Article

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Epigenetic Regulator Mll1 Is Required for Wnt-Driven Intestinal Tumorigenesis and Cancer Stemness

Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.
[Nature Communications]


USP47 Overcomes Tyrosine Kinase Inhibitor Resistance and Eradicates Leukemia Stem/Progenitor Cells in Chronic Myelogenous Leukemia

The knockout of Usp47 significantly inhibited BCR-ABL and BCR-ABLT315I-induced CML in mice with the reduction of Lin−Sca1+c-Kit+ chronic myelogenous leukemia stem/progenitor cells.
[Nature Communications]

Full Article

of Diverse Tumor Endothelial Cell Populations in Malignant Glioma

Using in utero electroporation and CRISPR/Cas9 genome engineering to generate a native, immunocompetent mouse model of glioma, the authors characterized vascular-tumor dynamics in three dimensions during tumor progression.


Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression

Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[Cell Reports]

Full ArticleGraphical Abstract

Decoding Hematopoiesis and Leukemogenesis Using Single-Cell Sequencing and Its Medical Implication

Scientists analyzed ~200,000 single-cell transcriptomes of bone marrow mononuclear cells and its subsets from 23 clinical samples. They constructed a comprehensive cell atlas as hematopoietic reference.
[Cell Discovery]

Full Article

Activators YAP/TAZ and AXL Orchestrate Dedifferentiation, Cell Fate, and Metastasis in Human Osteosarcoma

To identify key drivers of metastasis, scientists studied human CCH-osteocarcinoma (OS)-D OS cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy]

Full Article

EGFR and Oxidative Stress-Induced PKD1 Signaling Drive Formation of DCLK1+ Pancreatic Stem Cells

While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), the authors demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.

AbstractFull Article
Graphical Abstract

Promotes Stemness and Inhibits Type Ⅰ Interferon Signaling Pathway in Triple-Negative Breast Cancer

Researchers demonstrated that BTF3 expression is related with stem-like properties in triple negative breast cancer (TNBC) cells. BTF3 modulated stemness, migration and proliferation of TNBC in vitro.
[Biochemical and Biophysical Research Communications]


Survey Report: Where Is Pluripotent Stem Cell Research Now?

Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

IL-8 has been reported to favor cancer progression and metastases via different mechanisms, including pro-angiogenesis and maintenance of cancer stem cells, but its ability to attract and functionally modulate neutrophils and macrophages arguably may be the most important factors.
[Clinical Cancer Research]


Cancer Stemness Meets Immunity: From Mechanism to Therapy

Scientists review the cellular and molecular mechanisms underlying the symbiotic interactions between cancer stem cells and immune cells and how such heterotypic signaling maintains a tumor-promoting ecosystem and informs therapeutic strategies intercepting this co-dependency.
[Cell Reports]

Full Article

Global Coalition for Adaptive Research, Kazia, and Kintara Announce Commencement of Kazia’s Paxalisib and Kintara’s VAL-083 in GBM AGILE Trial

The Global Coalition for Adaptive Research (GCAR) in collaboration with Kazia and Kintara, announced the activation of Kazia’s paxalisib and Kintara’s VAL-083 in Glioblastoma (GBM) Adaptive Global Innovative Learning Environment (AGILE).
[Global Coalition for Adaptive Research]

Press Release

Integrating Metabolism and Immunity

January 25 – 28, 2021

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Research Assistant – Targeted Therapy in Breast Cancer

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

Salk Institute of Biological Studies – La Jolla, California, United States

Faculty Position – Skin Cancer

Columbia University Medical Center – New York, New York, United States

Investigator – Replication Stress and Chromatin Alterations

NIH National Cancer Institute – Bethesda, Maryland, United States

Dean and Faculty Positions – Brain Cancer Biology

Peking University Shenzhen Graduate School – Shenzhen, China

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