Cancer Stem Cell News Volume 10.00 | Jan 6 2021

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    2021-01-06 | 10.01


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.00 – 6 January, 2021
    TOP STORY

    Sequential
    Fate-Switches in Stem-Like Cells Drive the Tumorigenic Trajectory from Human Neural Stem Cells to Malignant Glioma

    Researchers established two highly penetrant human neural stem cell-derived malignant glioma models, which resembled the histopathology and transcriptional heterogeneity of human glioblastoma.
    [Cell Research]

    Full Article

    Explore scientific events this January with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    The
    Epigenetic Regulator Mll1 Is Required for Wnt-Driven Intestinal Tumorigenesis and Cancer Stemness

    Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.
    [Nature Communications]

    Abstract

    Targeting
    USP47 Overcomes Tyrosine Kinase Inhibitor Resistance and Eradicates Leukemia Stem/Progenitor Cells in Chronic Myelogenous Leukemia

    The knockout of Usp47 significantly inhibited BCR-ABL and BCR-ABLT315I-induced CML in mice with the reduction of Lin−Sca1+c-Kit+ chronic myelogenous leukemia stem/progenitor cells.
    [Nature Communications]

    Full Article

    Identification
    of Diverse Tumor Endothelial Cell Populations in Malignant Glioma

    Using in utero electroporation and CRISPR/Cas9 genome engineering to generate a native, immunocompetent mouse model of glioma, the authors characterized vascular-tumor dynamics in three dimensions during tumor progression.
    [Neuro-Oncology]

    Abstract

    Piwil1
    Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression

    Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Integrated
    Decoding Hematopoiesis and Leukemogenesis Using Single-Cell Sequencing and Its Medical Implication

    Scientists analyzed ~200,000 single-cell transcriptomes of bone marrow mononuclear cells and its subsets from 23 clinical samples. They constructed a comprehensive cell atlas as hematopoietic reference.
    [Cell Discovery]

    Full Article

    Transcriptional
    Activators YAP/TAZ and AXL Orchestrate Dedifferentiation, Cell Fate, and Metastasis in Human Osteosarcoma

    To identify key drivers of metastasis, scientists studied human CCH-osteocarcinoma (OS)-D OS cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
    [Cancer Gene Therapy]

    Full Article

    Dysfunctional
    EGFR and Oxidative Stress-Induced PKD1 Signaling Drive Formation of DCLK1+ Pancreatic Stem Cells

    While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), the authors demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.
    [iScience]

    AbstractFull Article
    Graphical Abstract

    BTF3
    Promotes Stemness and Inhibits Type Ⅰ Interferon Signaling Pathway in Triple-Negative Breast Cancer

    Researchers demonstrated that BTF3 expression is related with stem-like properties in triple negative breast cancer (TNBC) cells. BTF3 modulated stemness, migration and proliferation of TNBC in vitro.
    [Biochemical and Biophysical Research Communications]

    Abstract


    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    REVIEWS

    Interleukin-8,
    Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

    IL-8 has been reported to favor cancer progression and metastases via different mechanisms, including pro-angiogenesis and maintenance of cancer stem cells, but its ability to attract and functionally modulate neutrophils and macrophages arguably may be the most important factors.
    [Clinical Cancer Research]

    Abstract

    Cancer Stemness Meets Immunity: From Mechanism to Therapy

    Scientists review the cellular and molecular mechanisms underlying the symbiotic interactions between cancer stem cells and immune cells and how such heterotypic signaling maintains a tumor-promoting ecosystem and informs therapeutic strategies intercepting this co-dependency.
    [Cell Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    Global Coalition for Adaptive Research, Kazia, and Kintara Announce Commencement of Kazia’s Paxalisib and Kintara’s VAL-083 in GBM AGILE Trial

    The Global Coalition for Adaptive Research (GCAR) in collaboration with Kazia and Kintara, announced the activation of Kazia’s paxalisib and Kintara’s VAL-083 in Glioblastoma (GBM) Adaptive Global Innovative Learning Environment (AGILE).
    [Global Coalition for Adaptive Research]

    Press Release
    FEATURED EVENT

    Integrating Metabolism and Immunity

    January 25 – 28, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Senior
    Research Assistant – Targeted Therapy in Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

    Salk Institute of Biological Studies – La Jolla, California, United States

    Faculty Position – Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Senior
    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Dean and Faculty Positions – Brain Cancer Biology

    Peking University Shenzhen Graduate School – Shenzhen, China

    > See All Jobs

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