 | | Vol. 10.00 – 6 January, 2021 |
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| Researchers established two highly penetrant human neural stem cell-derived malignant glioma models, which resembled the histopathology and transcriptional heterogeneity of human glioblastoma.
[Cell Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.
[Nature Communications] |
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| The knockout of Usp47 significantly inhibited BCR-ABL and BCR-ABLT315I-induced CML in mice with the reduction of Lin−Sca1+c-Kit+ chronic myelogenous leukemia stem/progenitor cells.
[Nature Communications] |
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| Using in utero electroporation and CRISPR/Cas9 genome engineering to generate a native, immunocompetent mouse model of glioma, the authors characterized vascular-tumor dynamics in three dimensions during tumor progression.
[Neuro-Oncology] |
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| Researchers report that Piwi-like family members were overexpressed in glioblastoma, with Piwil1 most frequently overexpressed. Piwil1 was enriched in glioma stem-like cells to maintain self-renewal.
[Cell Reports] |
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| Scientists analyzed ~200,000 single-cell transcriptomes of bone marrow mononuclear cells and its subsets from 23 clinical samples. They constructed a comprehensive cell atlas as hematopoietic reference.
[Cell Discovery] |
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| To identify key drivers of metastasis, scientists studied human CCH-osteocarcinoma (OS)-D OS cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy] |
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| While PanIN cells expressed oncogenic KRas and have increased activity of epidermal growth factor receptor (EGFR), the authors demonstrated that in doublecortin-like kinase 1 (DCLK1+) PanIN cells EGFR signaling was not propagated to the nucleus.
[iScience] |
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| Researchers demonstrated that BTF3 expression is related with stem-like properties in triple negative breast cancer (TNBC) cells. BTF3 modulated stemness, migration and proliferation of TNBC in vitro.
[Biochemical and Biophysical Research Communications] |
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| IL-8 has been reported to favor cancer progression and metastases via different mechanisms, including pro-angiogenesis and maintenance of cancer stem cells, but its ability to attract and functionally modulate neutrophils and macrophages arguably may be the most important factors.
[Clinical Cancer Research] |
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| Scientists review the cellular and molecular mechanisms underlying the symbiotic interactions between cancer stem cells and immune cells and how such heterotypic signaling maintains a tumor-promoting ecosystem and informs therapeutic strategies intercepting this co-dependency.
[Cell Reports] |
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| The Global Coalition for Adaptive Research (GCAR) in collaboration with Kazia and Kintara, announced the activation of Kazia’s paxalisib and Kintara’s VAL-083 in Glioblastoma (GBM) Adaptive Global Innovative Learning Environment (AGILE).
[Global Coalition for Adaptive Research] |
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| January 25 – 28, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Peking University Shenzhen Graduate School – Shenzhen, China |
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