 | | Vol. 10.03 – 27 January, 2021 |
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| Using diverse pre-clinical models, the authors investigated the role of interferon regulatory factor 4 (IRF4) in myeloma progenitor regeneration.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists determined critical signaling for maintaining mucoepidermoid carcinoma (MEC) stem-like cells and the effect of combined targeting of stem cell signaling and CRTC1-MAML2-induced EGFR signaling on blocking MEC growth.
[Signal Transduction and Targeted Therapy] |
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| Extracellular matrix derived from irradiated astrocytes were found to be a major driver of this phenotype and astrocyte-derived transglutaminase 2 were identified as a promoter of glioma stemness and radioresistance.
[Cancer Research] |
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| Researchers performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose loss of function reversed Beclin 1-dependent inhibition of cellular proliferation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-leukemia stem cells from myeloproliferative neoplasm patients revealed APOBEC3C upregulation, an increased C-to-T mutational burden, and hematopoietic stem and progenitor cell proliferation during progression, which could be recapitulated by lentiviral APOBEC3C overexpression.
[Cell Reports] |
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| The authors identified CD93 as an important regulator of self-renewal and proliferation of murine and human leukemia stem cells, but not hematopoietic stem cells.
[Cell Reports] |
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| Scientists tested the hypothesis that mucoepidermoid carcinoma (MEC) CSC are sensitive to therapeutic inhibition of mTOR. They report a correlation between the long-term clinical outcomes of 17 MEC patients and the intratumoral expression of p-mTOR and p-S6K1.
[Cell Death & Disease] |
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| Hepatocellular carcinom cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on CSC characteristics.
[British Journal of Cancer] |
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| Researchers identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there was also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase.
[Cell Death Discovery] |
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| Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon CSC viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
[Scientific Reports] |
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| The authors attempt to integrate the established hallmarks of cancer with the plasticity of cancer cells as an emerging hallmark responsible for tumor heterogeneity, therapy resistance and relapse.
[Pharmaceuticals] |
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| Investigators review the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment, highlighting the potential use of CSC in tumor treatment.
[Cancer Cell International] |
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| Dr. Shujun Liu, head of the Cancer Epigenetics & Experimental Therapeutics lab and an Associate Professor at The Hormel Institute, was awarded a major grant from National Institutes of Health to research a new leukemia study.
[The Homel Institute] |
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| February 3 – 5, 2021
Virtual |
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| | University of Utah – Salt Lake City, Utah, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
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Extracellular Matrix News
Hematopoiesis News
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Intestinal Cell News
Mammary Cell News
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