Cancer Stem Cell News Volume 10.03 | Jan 27 2021


    2021-01-27 | CSCN 10.02

    Cancer Stem Cell News by STEMCELL Technologies

    Vol. 10.03 – 27 January, 2021


    Selective Antisense Oligonucleotide Inhibition of Human IRF4 Prevents Malignant Myeloma Regeneration via Cell Cycle Disruption

    Using diverse pre-clinical models, the authors investigated the role of interferon regulatory factor 4 (IRF4) in myeloma progenitor regeneration.
    [Cell Stem Cell]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Targeting Notch and EGFR Signaling in Human Mucoepidermoid Carcinoma

    Scientists determined critical signaling for maintaining mucoepidermoid carcinoma (MEC) stem-like cells and the effect of combined targeting of stem cell signaling and CRTC1-MAML2-induced EGFR signaling on blocking MEC growth.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2

    Extracellular matrix derived from irradiated astrocytes were found to be a major driver of this phenotype and astrocyte-derived transglutaminase 2 were identified as a promoter of glioma stemness and radioresistance.
    [Cancer Research]


    Tumor-Suppressor Function of Beclin 1 in Breast Cancer Cells Requires E-Cadherin

    Researchers performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose loss of function reversed Beclin 1-dependent inhibition of cellular proliferation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Inflammation-Driven Deaminase Deregulation Fuels Human Pre-Leukemia Stem Cell Evolution

    Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-leukemia stem cells from myeloproliferative neoplasm patients revealed APOBEC3C upregulation, an increased C-to-T mutational burden, and hematopoietic stem and progenitor cell proliferation during progression, which could be recapitulated by lentiviral APOBEC3C overexpression.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Metoclopramide Treatment Blocks CD93-Signaling-Mediated Self-Renewal of Chronic Myeloid Leukemia Stem Cells

    The authors identified CD93 as an important regulator of self-renewal and proliferation of murine and human leukemia stem cells, but not hematopoietic stem cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Survival of Salivary Gland Cancer Stem Cells Requires mTOR Signaling

    Scientists tested the hypothesis that mucoepidermoid carcinoma (MEC) CSC are sensitive to therapeutic inhibition of mTOR. They report a correlation between the long-term clinical outcomes of 17 MEC patients and the intratumoral expression of p-mTOR and p-S6K1.
    [Cell Death & Disease]

    Full Article

    Inhibiting CBX4 Efficiently Protects Hepatocellular Carcinoma Cells against Sorafenib Resistance

    Hepatocellular carcinom cell lines and a xenograft mouse model with resistance to sorafenib were employed to analyze the effects of miR424 on CSC characteristics.
    [British Journal of Cancer]


    ADO/Hypotaurine: A Novel Metabolic Pathway Contributing to Glioblastoma Development

    Researchers identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there was also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase.
    [Cell Death Discovery]

    Full Article

    Farnesyl Dimethyl Chromanol Targets Colon Cancer Stem Cells and Prevents Colorectal Cancer Metastasis

    Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon CSC viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
    [Scientific Reports]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.


    Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis

    The authors attempt to integrate the established hallmarks of cancer with the plasticity of cancer cells as an emerging hallmark responsible for tumor heterogeneity, therapy resistance and relapse.

    Full Article

    The Role of Hypoxia in the Tumor Microenvironment and Development of Cancer Stem Cell: A Novel Approach to Developing Treatment

    Investigators review the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment, highlighting the potential use of CSC in tumor treatment.
    [Cancer Cell International]

    Full Article


    Institute Scientist Awarded $4 Million for Leukemia Research

    Dr. Shujun Liu, head of the Cancer Epigenetics & Experimental Therapeutics lab and an Associate Professor at The Hormel Institute, was awarded a major grant from National Institutes of Health to research a new leukemia study.
    [The Homel Institute]

    Press Release


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    Assistant / Associate Professor – Brain Tumor

    University of Utah – Salt Lake City, Utah, United States

    Postdoctoral Fellow – Cancer Epigenetics

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    Staff Scientist – Medulloblastoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Senior Research Assistant – Targeted Therapy in Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

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