Cancer Stem Cell News Volume 10.04 | Feb 3 2021


    2021-01-03 | CSCN 10.04

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.04 – 3 February, 2021

    Mitochondrial Oxidative Metabolism Contributes to a Cancer Stem Cell Phenotype in Cholangiocarcinoma

    Investigators analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stem state in cholangiocarcinoma.
    [Journal of Hepatology]

    AbstractGraphical Abstract
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    Targeting Cancer Stem Cells with a Pan-BCL-2 Inhibitor in Pre-Clinical and Clinical Settings in Patients with Gastroesophageal Carcinoma

    Extensive pre-clinical studies in vitro and in vivo were carried out to establish the mechanism action of AT101 on targeting CSCs and antiapoptotic proteins.


    Genome-Wide CRISPR-Cas9 Screen Identified KLF11 as a Druggable Suppressor for Sarcoma Cancer Stem Cells

    Kruppel-like factor 11 (KLF11) recruited SIN3A/HDAC to suppress the transcriptional output of YAP/TEAD, which, in turn, promoted KLF11 transcription, forming a negative feedback loop.
    [Science Advances]

    Full Article

    Mesenchymal Stem Cell-Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region

    Investigators addressed the early period of dormancy when breast cancer cells entered bone marrow at the perivascular region to begin the transition into cancer stem cells, which they proposed as the final step in dormancy.
    [Cancer Research]


    Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

    Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.

    Full Article

    Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

    The authors investigated the expression of components of the renin-angiotensin system by CSC subpopulations in metastatic head and neck cutaneous squamous cell carcinoma.

    Full ArticleGraphical Abstract

    Comparative Stemness and Differentiation of Luminal and Basal Breast Cancer Stem Cell Type under Glutamine-Deprivation

    Scientists showed that breast cancer stem cells differentiated into CD24+ epithelial population under glutamine-deprivation and demonstrated increased expression of epithelial markers such as e-cadherin, claudin-1 and decreased expression of mesenchymal protein n-cadherin.
    [Journal of Cell Communication and Signaling]


    Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance

    Researchers accessed the TCGA open datasets, collected glioma tumor tissue samples, and analyzed the expression of kinesin family member 11 (KIF11) in glioma patients.
    [Cellular and Molecular Neurobiology]


    Berberine Inhibits Chemotherapy-Exacerbated Ovarian Cancer Stem Cell-Like Characteristics and Metastasis through GLI1

    The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
    [European Journal of Pharmacology]

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.

    The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer

    The authors focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. They further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse.
    [Trends in Cancer]

    Full ArticleGraphical Abstract

    EMT-Associated MicroRNAs and Their Roles in Cancer Stemness and Drug Resistance

    Scientists looked into the various roles that the epithelial-to-mesenchymal transition‐associated microRNAs play in the stem‐like nature of malignant cells.
    [Cancer Communications]

    Full Article


    Stuart H. Orkin receives the 2021 ISSCR Tobias Lecture Award

    The International Society for Stem Cell Research (ISSCR) awarded the 2021 Tobias Lecture Award to Stuart H. Orkin, MD, Boston Children’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School. “Stuart is one of the most accomplished and innovative physician-scientists in the world engaged in hematopoiesis research,” said Christine Mummery, ISSCR President.
    [The International Society for Stem Cell Research (EurekAlert!)]

    Press Release

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    Postdoctoral Fellowship – Human Cancers

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    Medical Scientist – Breast Cancer

    Gilead Sciences, Inc. – London, England, United Kingdom

    Assistant / Associate Professor – Brain Tumor

    University of Utah – Salt Lake City, Utah, United States

    Research Associate – Pediatric Myeloid Tumors

    St. Jude Children’s Hospital – Memphis, Tennessee, United States

    Staff Scientist – Medulloblastoma

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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