 | | Vol. 10.04 – 3 February, 2021 |
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| Investigators analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stem state in cholangiocarcinoma.
[Journal of Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Extensive pre-clinical studies in vitro and in vivo were carried out to establish the mechanism action of AT101 on targeting CSCs and antiapoptotic proteins.
[Gut] |
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| Kruppel-like factor 11 (KLF11) recruited SIN3A/HDAC to suppress the transcriptional output of YAP/TEAD, which, in turn, promoted KLF11 transcription, forming a negative feedback loop.
[Science Advances] |
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| Investigators addressed the early period of dormancy when breast cancer cells entered bone marrow at the perivascular region to begin the transition into cancer stem cells, which they proposed as the final step in dormancy.
[Cancer Research] |
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| Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers] |
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| The authors investigated the expression of components of the renin-angiotensin system by CSC subpopulations in metastatic head and neck cutaneous squamous cell carcinoma.
[Cells] |
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| Scientists showed that breast cancer stem cells differentiated into CD24+ epithelial population under glutamine-deprivation and demonstrated increased expression of epithelial markers such as e-cadherin, claudin-1 and decreased expression of mesenchymal protein n-cadherin.
[Journal of Cell Communication and Signaling] |
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| Researchers accessed the TCGA open datasets, collected glioma tumor tissue samples, and analyzed the expression of kinesin family member 11 (KIF11) in glioma patients.
[Cellular and Molecular Neurobiology] |
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| The authors found that chemotherapy exacerbated the migration and CSC-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition markers Vimentin and Snail.
[European Journal of Pharmacology] |
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| The authors focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. They further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse.
[Trends in Cancer] |
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| Scientists looked into the various roles that the epithelial-to-mesenchymal transition‐associated microRNAs play in the stem‐like nature of malignant cells.
[Cancer Communications] |
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| The International Society for Stem Cell Research (ISSCR) awarded the 2021 Tobias Lecture Award to Stuart H. Orkin, MD, Boston Children’s Hospital, Dana-Farber Cancer Institute, and Harvard Medical School. “Stuart is one of the most accomplished and innovative physician-scientists in the world engaged in hematopoiesis research,” said Christine Mummery, ISSCR President.
[The International Society for Stem Cell Research (EurekAlert!)] |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Gilead Sciences, Inc. – London, England, United Kingdom |
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| | University of Utah – Salt Lake City, Utah, United States |
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| | St. Jude Children’s Hospital – Memphis, Tennessee, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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