Cancer Stem Cell News Volume 10.08 | Mar 3 2021


    2021-03-03 | CSCN 10.08

    Cancer Stem Cell News by STEMCELL Technologies
    Vol.10.08 – 3 March, 2021

    Identification of Leukemic and Pre-Leukemic Stem Cells by Clonal Tracking from Single-Cell Transcriptomics

    Researchers demonstrated that leukemia stem cells, hematopoietic stem cells, and pre-leukemic stem cells could be identified and molecularly profiled by combining single-cell transcriptomics with lineage tracing using both nuclear and mitochondrial somatic variants.
    [Nature Communications]

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    OTS167 Blocks FLT3 Translation and Synergizes with FLT3 Inhibitors in FLT3 Mutant Acute Myeloid Leukemia

    OTS167 alone or in combination with tyrosine kinase inhibitors were used to investigate the effect of OTS167 on FLT3 signaling and expression in human Fms-like tyrosine kinase 3 (FLT3) mutant acute myeloid leukemia cell lines and primary cells.
    [Blood Cancer Journal]

    Full Article

    IL-17B/IL-17RB Signaling Cascade Contributes to Self-Renewal and Tumorigenesis of Cancer Stem Cells by Regulating Beclin-1 Ubiquitination

    The authors found that IL-17RB expression was significantly upregulated in spheroid cells and Lgr5-positive cells from the same tumor tissues of patients with gastric cancer, which was closely correlated with the degree of cancer cell differentiation.

    Full Article

    TGFβ/Cyclin D1/Smad-Mediated Inhibition of BMP4 Promotes Breast Cancer Stem Cell Self-Renewal Activity

    Scientists investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in triple negative breast cancer (TNBC). They found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low CSC population.

    Full Article

    Inhibition of Bruton’s Tyrosine Kinase as a Therapeutic Strategy for Chemoresistant Oral Squamous Cell Carcinoma and Potential Suppression of Cancer Stemness

    Researchers investigated the effects of Bruton’s tyrosine kinase (BTK) on oncurrent chemoradiotherapy-resistant oral squamous cell carcinoma tissues (OSCC). The effect of ibrutinib, a first-in-class BTK inhibitor, was tested on stem cell-like OSCC tumorspheres.

    Full Article

    Simultaneously Target of Normal and Stem Cells-Like Gastric Cancer Cells via Cisplatin and Anti-CD133 CAR-T Combination Therapy

    Cisplatin and anti-CD133 chimeric antigen receptor T (CAR-T) combination treatment inhibited tumor progression in three different xenograft models with diminished CD133 positive stem cell-like cell infiltration.
    [Cancer Immunology Immunotherapy]


    Bortezomib Suppresses Self-Renewal and Leukemogenesis of Leukemia Stem Cell by NF-ĸB-Dependent Inhibition of CDK6 in MLL-Rearranged Myeloid Leukemia

    Investigators found that bortezomib (bort) suppressed cell proliferation and decreased colony formation in human and murine leukemic blasts. Bort reduced the frequency and function of leukemia stem cells, inhibited the progression, and extended the overall survival in mixed‐lineage leukemia‐AF9‐transformed leukemic mice.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Epithelial–Mesenchymal Transition and Cancer Stem Cell Interactions in Breast Phyllodes Tumors: Immunohistochemical Evaluation of EZH2, EZR, HMGA2, CD24 and CD44 in Correlation with Outcome Analysis

    Using tissue microarray sections, immunohistochemistry was performed on 360 PTs. Epithelial and stromal expressions of EZH2, EZR, HMGA2, CD24 and CD44 were evaluated to assess their impact on disease progression and behavior in correlation with clinicopathological parameters.
    [Cancer Cell International]


    Electrospun Nanofiber Scaffolds for the Propagation and Analysis of Breast Cancer Stem Cells In Vitro

    The authors developed a 3D culture platform that mimics the metastatic tumor extracellular matrix to effectively increase CSC population in vitro and allow CSC analysis.
    [Biomedical Materials]

    Explore scientific events this March with the Science Events Calendar.

    Disseminated Cancer Cells in Breast Cancer: Mechanism of Dissemination and Dormancy and Emerging Insights on Therapeutic Opportunities

    Scientists discuss the recent advancements of molecular pathways involving breast cancer cell dissemination, role of chemokine-chemokine receptor networks in disseminated cancer cells (DCCs) migration, DCCs phenotypic heterogeneity and unique genes signatures in tumor dormancy, microenvironmental regulation and specific niches that favors DCCs homing and dormancy.
    [Seminars in Cancer Biology]


    Glioma Stem Cells as Immunotherapeutic Targets: Advancements and Challenges

    The authors discuss recent advances in glioblastoma treatment specifically focused on targeting of glioma stem cells as well as their potential integration into current clinical pathways and trials.
    [Frontiers in Oncology]

    Full Article

    Orbus Therapeutics Announces Positive Outcome of Pre-Planned Interim Futility Analysis for Phase III Eflornithine STELLAR Study

    Orbus Therapeutics, Inc. announced a positive outcome of the pre-planned interim analysis for futility in its Phase III STELLAR clinical study of eflornithine in patients with recurrent anaplastic astrocytoma.
    [Orbus Therapeutics, Inc.]

    Press Release

    National Marrow Donor Program/Be The Match Announce Plan to Launch ACCESS Clinical Trial

    The National Marrow Donor Program®/Be The Match® announced plans to launch the ACCESS clinical trial titled “A Multicenter Phase II Trial of HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide for Patients with Hematologic Malignancies.”
    [The National Marrow Donor Program®]

    Press Release


    CUGH 2021: Addressing Critical Gaps in Global Health and Development

    April 12 – 14, 2021

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    Postdoctoral Scientist – Senescence and Cancer

    Cancer Research Center of Lyon – Lyon, France

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    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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    University of Notre Dame – Notre Dame, Indiana, United States

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