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Vol. 10.09 – 10 March, 2021
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The authors identified E26 transformation-specific homologous factor as a key molecule in decreasing the sensitivity of pancreatic cancer cells to cancer stem cells’ niche stimulus.
[Gut]
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PUBLICATIONSRanked by the impact factor of the journal
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Human embryonic stem cells were induced to differentiate into hepatocytes along hepatic lineages to mimic liver development in vitro.
[Nature Communications]
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Investigators revealed that the phosphorylation state of the HV H2A.X (γH2A.X) regulated self-renewal and differentiation of human pluripotent stem cells and leukemic progenitors.
[Cell Reports]
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Innovated AR-independent therapy might alleviate enzalutamide resistance and prevent production of adverse side effects. Scientists identified that yes-associated protein 1 (YAP1) was overexpressed in enzalutamide-resistant cells.
[Oncogene]
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Researchers demonstrated that aurora-A kinase is required to mediate TGF-β-induced expression of the SNAI1 gene, enrichment of ALDH1high breast tumor-initiating cells, self-renewal capacity, and chemoresistance in TNBC experimental models.
[Oncogene]
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A distinct heterogeneity in GASC1 levels was observed among hepatocellular carcinoma cell populations, predicting their inherent high or low tumor-initiating capacity.
[Cell Death & Disease]
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Scientists characterized and identify a subpopulation of CD133+ cancer stem-like cells derived from SK-UT-1 cell line.
[Cancer Cell International]
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Investigators established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducible Meis1.dTomato to study growth behavior, immunophenotype and morphology under different cytokine/microenvironmental conditions ex vivo upon doxycycline induction or removal.
[Scientific Reports]
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CSC capacities were evaluated regarding capacity to form spheres, expression of stem cell markers and the presence of ALDHhigh cells.
[BMC Cancer]
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Scientists discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients.
[Cell Stem Cell]
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Investigators summarize the molecular mechanism by which CSCs-derived extracellular vesicles in tumor progression.
[Signal Transduction and Targeted Therapy]
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The authors review a wide range of both immunocapture and label free circulating tumor cell enrichment technologies, summarising the most significant advantages and disadvantages of each.
[Cancers]
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OncoSynergy, Inc. announced that the first patient was treated in the company’s First-in-Human Phase I clinical trial evaluating OS2966 for the treatment of recurrent glioblastoma at Moffitt Cancer Center in Tampa, Florida. OS2966 is a first-in-class immunotherapy, and the first ever anti-CD29 therapeutic to reach human trials.
[OncoSynergy, Inc. (PR Newswire. LLC)]
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Kite, a Gilead Company announced that the FDA has granted accelerated approval to Yescarta® for the treatment of adult patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy.
[Gilead Sciences, Inc.]
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US Congressman Donald Norcross announced that the Coriell Institute for Medical Research, located in Camden, has been awarded a $408,617 grant from the National Cancer Institute. This grant will go towards a research project aimed at exploring drug resistance in patients with acute myeloid leukemia.
[Donald Norcross]
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The University of British Columbia – Vancouver, British Columbia, Canada
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UC San Francisco – Location
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Cancer Research Center of Lyon – Lyon, France
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Dana-Farber Cancer Institute – Boston, Massachusetts, United States
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University of Notre Dame – Notre Dame, Indiana, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News
