 | | Vol. 10.09 – 10 March, 2021 |
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| The authors identified E26 transformation-specific homologous factor as a key molecule in decreasing the sensitivity of pancreatic cancer cells to cancer stem cells’ niche stimulus.
[Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Human embryonic stem cells were induced to differentiate into hepatocytes along hepatic lineages to mimic liver development in vitro.
[Nature Communications] |
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| Investigators revealed that the phosphorylation state of the HV H2A.X (γH2A.X) regulated self-renewal and differentiation of human pluripotent stem cells and leukemic progenitors.
[Cell Reports] |
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| Innovated AR-independent therapy might alleviate enzalutamide resistance and prevent production of adverse side effects. Scientists identified that yes-associated protein 1 (YAP1) was overexpressed in enzalutamide-resistant cells.
[Oncogene] |
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| Researchers demonstrated that aurora-A kinase is required to mediate TGF-β-induced expression of the SNAI1 gene, enrichment of ALDH1high breast tumor-initiating cells, self-renewal capacity, and chemoresistance in TNBC experimental models.
[Oncogene] |
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| A distinct heterogeneity in GASC1 levels was observed among hepatocellular carcinoma cell populations, predicting their inherent high or low tumor-initiating capacity.
[Cell Death & Disease] |
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| Scientists characterized and identify a subpopulation of CD133+ cancer stem-like cells derived from SK-UT-1 cell line.
[Cancer Cell International] |
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| Investigators established conditionally immortalised myeloid progenitor cell lines co-expressing constitutive Hoxa9.EGFP and inducible Meis1.dTomato to study growth behavior, immunophenotype and morphology under different cytokine/microenvironmental conditions ex vivo upon doxycycline induction or removal.
[Scientific Reports] |
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| CSC capacities were evaluated regarding capacity to form spheres, expression of stem cell markers and the presence of ALDHhigh cells.
[BMC Cancer] |
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| Scientists discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients.
[Cell Stem Cell] |
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| Investigators summarize the molecular mechanism by which CSCs-derived extracellular vesicles in tumor progression.
[Signal Transduction and Targeted Therapy] |
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| The authors review a wide range of both immunocapture and label free circulating tumor cell enrichment technologies, summarising the most significant advantages and disadvantages of each.
[Cancers] |
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| OncoSynergy, Inc. announced that the first patient was treated in the company’s First-in-Human Phase I clinical trial evaluating OS2966 for the treatment of recurrent glioblastoma at Moffitt Cancer Center in Tampa, Florida. OS2966 is a first-in-class immunotherapy, and the first ever anti-CD29 therapeutic to reach human trials.
[OncoSynergy, Inc. (PR Newswire. LLC)] |
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| Kite, a Gilead Company announced that the FDA has granted accelerated approval to Yescarta® for the treatment of adult patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy.
[Gilead Sciences, Inc.] |
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| US Congressman Donald Norcross announced that the Coriell Institute for Medical Research, located in Camden, has been awarded a $408,617 grant from the National Cancer Institute. This grant will go towards a research project aimed at exploring drug resistance in patients with acute myeloid leukemia.
[Donald Norcross] |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | UC San Francisco – Location |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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