Cancer Stem Cell News Volume 10.10 | Mar 17 2021

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    2021-03-17 | CSCN 10.10


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.10 – 17 March, 2021
    TOP STORY

    CDK8 Maintains Stemness and Tumorigenicity of Glioma Stem Cells by Regulating the C-MYC Pathway
    Investigators demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
    [Oncogene]
    Abstract

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    HER2-Targeted Antibody-Drug Conjugate Induces Host Immunity against Cancer Stem Cells
    The authors tested HER2-targeted antibody-drug conjugates in two immunocompetent mouse tumor models.
    [Cell Chemical Biology]
    AbstractGraphical Abstract

    Shc3 Promotes Hepatocellular Carcinoma Stemness and Drug Resistance by Interacting with β-Catenin to Inhibit Its Ubiquitin Degradation Pathway
    Scientists observed high Shc3 expression in patients with chemoresistant and recurrent hepatocellular carcinomas. Shc3 overexpression induced a significant increase in MDR1/P-glycoprotein expression, whereas Shc3 knockdown impaired this expression.
    [Cell Death & Disease]
    Full Article

    p97/VCP Is Highly Expressed in the Stem-Like Cells of Breast Cancer and Controls Cancer Stemness Partly through the Unfolded Protein Response
    Researchers examined p97 expression in the stem-like cancer cells or CSCs, a cell population that purportedly underscores cancer initiation, therapeutic resistance, and recurrence.
    [Cell Death & Disease]
    Full Article

    MAGI1 Inhibits the AMOTL2/p38 Stress Pathway and Prevents Luminal Breast Tumorigenesis
    The authors showed that the loss of the junctional scaffold protein MAGI1 was associated with bad prognosis in luminal breast cancer, and promoted tumorigenesis.
    [Scientific Reports]
    Full Article

    All-Trans Retinoic Acid and Protein Kinase C α/β1 Inhibitor Combined Treatment Targets Cancer Stem Cells and Impairs Breast Tumor Progression
    Employing hormone-independent mammary cancer models, Gö6976 and all-trans-retinoic acid combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile.
    [Scientific Reports]
    Full Article

    Correlation between the Expression of Cancer Stem Cell Marker BMI1 and Glioma Prognosis
    The authors investigated B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) expression in brain tumors using microarray datasets in ONCOMINE, which indicated that BMI1 levels were not commonly increased in clinical brain tumors.
    [Biochemical and Biophysical Research Communications]
    Abstract

    1 E-Cadherin Knockdown Induces Cancer Stem Cell-Like Phenotype and Drug Resistance
    CSC phenotype cells were isolated and the expression of stem cell marker and epithelial-mesenchymal transition associated gene was confirmed by various assays.
    [Biochemistry and Cell Biology]
    Abstract

    The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells
    Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
    [Biochemical Genetics]
    Abstract
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    REVIEWS

    Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells
    Since CSCs mirror the phenotypic behavior of stem cells, scientists describe the roles played by YY1 in embryonic and adult stem cells.
    [Stem Cell Reviews and Reports]
    Full ArticleGraphical Abstract

    From Sorting to Sequencing in the Molecular Era: The Evolution of the Cancer Stem Cell Model in Medulloblastoma
    The author examines the last two decades of CSC studies in the field. Seminal discoveries, emerging controversies and outstanding questions will be covered with a particular focus on medulloblastoma, the most common malignant primary brain tumor in children.
    [FEBS Journal]
    Abstract
    INDUSTRY AND POLICY NEWS

    AVEO Oncology Announces Collaboration with Bristol Myers Squibb to Evaluate FOTIVDA® (Tivozanib) in Combination with OPDIVO® (Nivolumab) in Pivotal Phase III TiNivo-2 Trial in IO Relapsed Renal Cell Carcinoma
    AVEO Oncology announced that it has entered into a clinical trial collaboration and supply agreement with Bristol Myers Squibb to evaluate FOTIVDA® in combination with OPDIVO®, Bristol Myers Squibb’s anti-PD-1 therapy, in the pivotal Phase III TiNivo-2 trial in patients with advanced relapsed or refractory renal cell carcinoma following prior immunotherapy exposure.
    [AVEO Oncology]
    Press Release

    Rubius Therapeutics Reports Initial Clinical Data from Ongoing Phase I/II Trial of RTX-240 in Patients with Advanced Solid Tumors, Demonstrating Single-Agent Activity
    Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors.
    [Rubius Therapeutics, Inc.]
    Press Release

    Children’s Cancer Research Fund Announces $10.5 Million in New Grants to Accelerate Childhood Cancer Research
    Children’s Cancer Research Fund is proud to award $10.5 million in its latest round of funding. The new grants support 12 research organizations that are working to improve treatment and outcomes for children and adolescents with cancer.
    [Children’s Cancer Research Fund]
    Press Release
    FEATURED EVENT

    Leukopak Processing: Tips for Streamlined Cell Isolation
    March 31, 2021
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    JOB OPPORTUNITIES

    Director – Ginny L. Clements Breast Cancer Research Institute
    University of Arizona Cancer Center – Tucson, Arizona, United States

    Research Coordinator – Breast Oncology
    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Scholar Position – Hormone Therapy Resistance in Prostate Cancer
    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow Position – Sarcoma Biology
    The University of British Columbia – Vancouver, British Columbia, Canada

    Assistant Professor – Neuro-Oncology
    UC San Francisco – San Francisco, California, United States

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