Cancer Stem Cell News Volume 10.18 | May 12 2021

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    2021-05-12 | CSCN 10.18


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.18 – 12 May, 2021
    TOP STORY

    Activation of Transmembrane Receptor Tyrosine Kinase DDR1-STAT3 Cascade by Extracellular Matrix Remodeling Promotes Liver Metastatic Colonization in Uveal Melanoma

    The authors hypothesized that DDR1 and its ligand might ignite the interaction between uveal melanoma cells and their surrounding niche of the liver thereby conferring strengthened survival, proliferation, stemness and eventually promoting metastatic colonization in the liver.
    [Signal Transduction and Targeted Therapy]

    Full Article


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    An RFC4/Notch1 Signaling Feedback Loop Promotes NSCLC Metastasis and Stemness

    To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in non-small-cell lung carcinoma (NSCLC) cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
    [Nature Communications]

    Full Article

    Arginine Methyltransferase PRMT5 Methylates and Stabilizes KLF5 via Decreasing Its Phosphorylation and Ubiquitination to Promote Basal-Like Breast Cancer

    Protein arginine methyltransferase 5 (PRMT5) promoted breast cancer stem cell maintenance and proliferation, at least partially, by stabilizing krüppel-like factor 5 (KLF5).
    [Cell Death & Differentiation]

    Abstract

    Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer

    Interleukin enhancer-binding factor 2 (ILF2) facilitated nuclear mRNA export and inhibited hMTR4-mediated exosomal degradation to promote stabilization and expression of SOX2, NANOG, and SALL4, resulting in enhanced stemness and tumor-initiating capacity of esophageal cancer cells.
    [Cancer Research]

    Abstract

    C/EBPβ Is a MYB- and p300-Cooperating Pro-Leukemogenic Factor and Promising Drug Target in Acute Myeloid Leukemia

    Scientists characterized a group of natural sesquiterpene lactones, previously shown to suppress MYB activity, for their potential to decrease acute myeloid leukemia cell proliferation.
    [Oncogene]

    Full Article

    Functional Inhibition of Cancer Stemness-Related Protein DPP4 Rescues Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma

    The authors established patient-derived renal cell carcinoma spheroids and showed that dipeptidyl peptidase IV (DPP4) expression was associated with stemness-related gene expression.
    [Oncogene]

    Abstract

    Exosomal circ_0030167 Derived from BM-MSCs Inhibits the Invasion, Migration, Proliferation and Stemness of Pancreatic Cancer Cells by Sponging miR-338-5p and Targeting the Wif1/Wnt8/β-Catenin Axis

    Researchers found that bone marrow-mesenchymal stem cell (BM-MSC)-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness.
    [Cancer Letters]

    Abstract

    Adipocyte-Like Signature in Ovarian Cancer Minimal Residual Disease Identifies Metabolic Vulnerabilities of Tumor Initiating Cells

    Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.
    [JCI Insight]

    AbstractFull Article

    LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

    The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
    [Laboratory Investigation]

    Full Article

    Mucosal Ribosomal Stress-Induced PRDM1 Promotes Chemoresistance via Stemness Regulation

    Stress-driven ribosomal dysfunction enhanced PR domain zinc finger protein 1 (PRDM1) levels in intestinal cancer cells, which contributed to their survival and enhanced cancer cell stemness against cancer treatment.
    [Communications Biology]

    Full Article

    Apatinib Suppresses Lung Cancer Stem-Like Cells by Complex Interplay between β-Catenin Signaling and Mitochondrial ROS Accumulation

    Investigators demonstrated that apatinib repressed lung CSC-like traits by hindering sphere formation ability, lung CSC-related marker expression, and decreasing chemoresistance derived stemness.
    [Cell Death Discovery]

    Full Article

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    REVIEWS

    The Role of CD44 in Cancer Chemoresistance: A Concise Review

    Scientists demonstrate the various cross-talk between CD44 and intracellular and extracellular factors and highlight its role in developing chemoresistant tumors in some troublesome cancers.
    [European Journal of Pharmacology]

    Abstract

    INDUSTRY AND POLICY NEWS

    WPD Pharmaceuticals to Receive $6.7 Million Grant for Development of Annamycin Drug Candidate

    WPD Pharmaceuticals, Inc. announced that it has been conditionally awarded a grant of $6,730,036 from the Polish National Center for Research and Development, for the development of Annamycin, the company’s drug candidate used in the treatment of Acute Myeloid Leukemia.
    [WPD Pharmaceuticals, Inc.]

    Press Release

    GT Biopharma Announces Update On The Commencement Of The GTB-3550 TriKE™ Monotherapy Phase II Clinical Trial And Solid Tumor TriKE™ Product Candidates

    GT Biopharma, Inc. provided an update concerning the commencement of the GTB-3550 TriKE monotherapy Phase II clinical trial, and certain of its solid tumor targeting TriKE product candidates.
    [GT Biopharma, Inc.]

    Press Release

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Non-Classical Mechanisms of Therapy Resistance

    Cedars-Sinai – Los Angeles, California, United States

    Postdotoral Research Fellow – Cancer Stem Cells of Liver Cancer and Tumor Immunology

    National Institutes of Health – Bethesda, Maryland, United States

    Postdotoral Research Fellow – Cancer Stem Cells

    Virginia Commonwealth University – Richmond, Virginia, United States

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Pediatric Oncology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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