Cancer Stem Cell News Volume 10.18 | May 12 2021

2021-05-12 | CSCN 10.18

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.18 – 12 May, 2021

Activation of Transmembrane Receptor Tyrosine Kinase DDR1-STAT3 Cascade by Extracellular Matrix Remodeling Promotes Liver Metastatic Colonization in Uveal Melanoma

The authors hypothesized that DDR1 and its ligand might ignite the interaction between uveal melanoma cells and their surrounding niche of the liver thereby conferring strengthened survival, proliferation, stemness and eventually promoting metastatic colonization in the liver.
[Signal Transduction and Targeted Therapy]

Full Article

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An RFC4/Notch1 Signaling Feedback Loop Promotes NSCLC Metastasis and Stemness

To understand how Notch signaling was overactivated to couple tumor metastasis and self-renewal in non-small-cell lung carcinoma (NSCLC) cells, researchers showed that RFC4, directly bound to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1.
[Nature Communications]

Full Article

Arginine Methyltransferase PRMT5 Methylates and Stabilizes KLF5 via Decreasing Its Phosphorylation and Ubiquitination to Promote Basal-Like Breast Cancer

Protein arginine methyltransferase 5 (PRMT5) promoted breast cancer stem cell maintenance and proliferation, at least partially, by stabilizing krüppel-like factor 5 (KLF5).
[Cell Death & Differentiation]


Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer

Interleukin enhancer-binding factor 2 (ILF2) facilitated nuclear mRNA export and inhibited hMTR4-mediated exosomal degradation to promote stabilization and expression of SOX2, NANOG, and SALL4, resulting in enhanced stemness and tumor-initiating capacity of esophageal cancer cells.
[Cancer Research]


C/EBPβ Is a MYB- and p300-Cooperating Pro-Leukemogenic Factor and Promising Drug Target in Acute Myeloid Leukemia

Scientists characterized a group of natural sesquiterpene lactones, previously shown to suppress MYB activity, for their potential to decrease acute myeloid leukemia cell proliferation.

Full Article

Functional Inhibition of Cancer Stemness-Related Protein DPP4 Rescues Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma

The authors established patient-derived renal cell carcinoma spheroids and showed that dipeptidyl peptidase IV (DPP4) expression was associated with stemness-related gene expression.


Exosomal circ_0030167 Derived from BM-MSCs Inhibits the Invasion, Migration, Proliferation and Stemness of Pancreatic Cancer Cells by Sponging miR-338-5p and Targeting the Wif1/Wnt8/β-Catenin Axis

Researchers found that bone marrow-mesenchymal stem cell (BM-MSC)-derived exosomes significantly reduced the invasion, migration, and proliferation of pancreatic cancer cells, as well as tumor stemness.
[Cancer Letters]


Adipocyte-Like Signature in Ovarian Cancer Minimal Residual Disease Identifies Metabolic Vulnerabilities of Tumor Initiating Cells

Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.
[JCI Insight]

AbstractFull Article

LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
[Laboratory Investigation]

Full Article

Mucosal Ribosomal Stress-Induced PRDM1 Promotes Chemoresistance via Stemness Regulation

Stress-driven ribosomal dysfunction enhanced PR domain zinc finger protein 1 (PRDM1) levels in intestinal cancer cells, which contributed to their survival and enhanced cancer cell stemness against cancer treatment.
[Communications Biology]

Full Article

Apatinib Suppresses Lung Cancer Stem-Like Cells by Complex Interplay between β-Catenin Signaling and Mitochondrial ROS Accumulation

Investigators demonstrated that apatinib repressed lung CSC-like traits by hindering sphere formation ability, lung CSC-related marker expression, and decreasing chemoresistance derived stemness.
[Cell Death Discovery]

Full Article

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The Role of CD44 in Cancer Chemoresistance: A Concise Review

Scientists demonstrate the various cross-talk between CD44 and intracellular and extracellular factors and highlight its role in developing chemoresistant tumors in some troublesome cancers.
[European Journal of Pharmacology]



WPD Pharmaceuticals to Receive $6.7 Million Grant for Development of Annamycin Drug Candidate

WPD Pharmaceuticals, Inc. announced that it has been conditionally awarded a grant of $6,730,036 from the Polish National Center for Research and Development, for the development of Annamycin, the company’s drug candidate used in the treatment of Acute Myeloid Leukemia.
[WPD Pharmaceuticals, Inc.]

Press Release

GT Biopharma Announces Update On The Commencement Of The GTB-3550 TriKE™ Monotherapy Phase II Clinical Trial And Solid Tumor TriKE™ Product Candidates

GT Biopharma, Inc. provided an update concerning the commencement of the GTB-3550 TriKE monotherapy Phase II clinical trial, and certain of its solid tumor targeting TriKE product candidates.
[GT Biopharma, Inc.]

Press Release


Precision Oncology: Translating Discovery to the Clinic

June 21 – 24, 2021

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Postdoctoral Scientist – Non-Classical Mechanisms of Therapy Resistance

Cedars-Sinai – Los Angeles, California, United States

Postdotoral Research Fellow – Cancer Stem Cells of Liver Cancer and Tumor Immunology

National Institutes of Health – Bethesda, Maryland, United States

Postdotoral Research Fellow – Cancer Stem Cells

Virginia Commonwealth University – Richmond, Virginia, United States

Senior Scientific Editor – Cell Stem Cell

Elsevier – Cambridge, Massachusetts, United States

Postdoctoral Fellow – Pediatric Oncology

Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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