Cancer Stem Cell News Volume 10.21 | Jun 2 2021


    2021-06-02 | CSCN 10.21

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.21 – 2 June, 2021

    In Vivo Flow Cytometry Reveals a Circadian Rhythm of Circulating Tumor Cells

    Scientists applied fluorescence in vivo flow cytometry to monitor circulating tumor cells noninvasively in an orthotopic mouse model of human prostate cancer.
    [Light-Science & Applications]

    Full Article

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    High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

    Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induced a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
    [Proceedings of the National Academy of Sciences of the United States of America]


    Oct4 Confers Stemness and Radioresistance to Head and Neck Squamous Cell Carcinoma by Regulating the Homologous Recombination Factors PSMC3IP and RAD54L

    Investigators provided evidence that the CSC-related transcription factor Oct4 contributed to head and neck squamous cell carcinoma radioresistance by regulating DNA damage response and the CSC phenotype.

    Full Article

    FAK Inhibition Alone or in Combination with Adjuvant Therapies Reduces Cancer Stem Cell Activity

    The authors determined the effect of focal adhesion kinase (FAK) inhibition on breast CSC activity alone and in combination with adjuvant therapies.
    [npj Breast Cancer]

    Full Article

    MicroRNA-200c Restoration Reveals a Cytokine Profile to Enhance M1 Macrophage Polarization in Breast Cancer

    To determine how triple negative breast cancer (TNBC) suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.
    [npj Breast Cancer]

    Full Article

    Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells

    Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
    [International Journal of Molecular Sciences]

    Full Article

    Fatty Acid β-Oxidation Promotes Breast Cancer Stemness and Metastasis via the miRNA-328-3p-CPT1A Pathway

    The authors found miR-328-3p to be significantly downregulated in breast cancer, revealing it as a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also as a model for the miRNA-fatty acid β-oxidation-stemness axis.
    [Cancer Gene Therapy]

    Full Article

    CHK1 Inhibitor Sensitizes Resistant Colorectal Cancer Stem Cells to Nortopsentin

    Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.

    Full ArticleGraphical Abstract

    BRM270 and Endostatin Synergistically Inhibit the Relapse of Non-Small Cell Lung Cancer While Suppressing Lung Cancer Stem Cells Proliferation Induced by Endostatin

    Researchers clarified whether BRM270 could inhibit the proliferation of CSCs. Endostatin + BRM270 showed anti-tumor effects by reducing tumor volume and increasing survival.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    ETV4 Promotes Breast Cancer Cell Stemness by Activating Glycolysis and CXCR4-Mediated Sonic Hedgehog Signaling

    Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
    [Cell Death Discovery]

    Full Article

    NUMB Suppression by miR-9-5P Enhances CD44+ Prostate Cancer Stem Cell Growth and Metastasis

    MiR-9-5p reduced NUMB expression and inhibited numerous prostate CSC properties including proliferation, migration, invasion as well as self-renewal.
    [Scientific Reports]

    Full Article

    Survey results on the needs and challenges in the human pluripotent stem cell field

    Current Understanding of Epigenetics Mechanism as a Novel Target in Reducing Cancer Stem Cells Resistance

    The authors explore recent information about the biology and characteristics of CSCs, including CSCs markers, CSCs niche, the relationship between epithelial to mesenchymal transition and CSCs, the factors that create resistance and influencing the generation of them.
    [Clinical Epigenetics]

    Full Article

    Long Non-Coding RNAs in Cancer Stem Cells

    LncRNAs have been involved in both CSC biology and cancer progression, prognosis, and recurrence. Investigators review the most recent literature on IncRNAs involvement in CSC biology and function.
    [Translational Oncology]

    AbstractFull ArticleGraphical Abstract


    Ryvu Therapeutics Got Full Approval to Conduct Phase I/II Study of RVU120 (SEL120) in Patients with Relapsed/Refractory Metastatic or Advanced Solid Tumors in Poland

    Ryvu Therapeutics announced that its Clinical Trial Application to commence a single-agent, open-label Phase I/II trial, investigating the safety and efficacy of RVU120 in patients with relapsed/refractory metastatic or advanced solid tumors in Poland, has been fully approved.
    [Ryvu Therapeutics]

    Press Release


    Cancer Discovery Symposium

    June 21 – 22, 2021

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    Postdoctoral Positions – Hematopoiesis and Leukemia

    UT Southwestern Medical Center – Dallas, Texas, United Statess

    Director – The Roslin Institute

    The University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Position – Stemness Control in Pluripotent and Cancer Cells

    Columbia University Medical Center – New York, New York, United States

    Research Associate – Senescence in Cancer

    University of Cambridge – Cambridge, England, United Kingdom

    Faculty Positions – Immuno-Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

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