 | | Vol. 10.21 – 2 June, 2021 |
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| Scientists applied fluorescence in vivo flow cytometry to monitor circulating tumor cells noninvasively in an orthotopic mouse model of human prostate cancer.
[Light-Science & Applications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induced a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators provided evidence that the CSC-related transcription factor Oct4 contributed to head and neck squamous cell carcinoma radioresistance by regulating DNA damage response and the CSC phenotype.
[Oncogene] |
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| The authors determined the effect of focal adhesion kinase (FAK) inhibition on breast CSC activity alone and in combination with adjuvant therapies.
[npj Breast Cancer] |
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| To determine how triple negative breast cancer (TNBC) suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.
[npj Breast Cancer] |
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| Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
[International Journal of Molecular Sciences] |
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| The authors found miR-328-3p to be significantly downregulated in breast cancer, revealing it as a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also as a model for the miRNA-fatty acid β-oxidation-stemness axis.
[Cancer Gene Therapy] |
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| Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.
[iScience] |
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| Researchers clarified whether BRM270 could inhibit the proliferation of CSCs. Endostatin + BRM270 showed anti-tumor effects by reducing tumor volume and increasing survival.
[Molecular Therapy-Oncolytics] |
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| Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
[Cell Death Discovery] |
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| MiR-9-5p reduced NUMB expression and inhibited numerous prostate CSC properties including proliferation, migration, invasion as well as self-renewal.
[Scientific Reports] |
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| The authors explore recent information about the biology and characteristics of CSCs, including CSCs markers, CSCs niche, the relationship between epithelial to mesenchymal transition and CSCs, the factors that create resistance and influencing the generation of them.
[Clinical Epigenetics] |
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| LncRNAs have been involved in both CSC biology and cancer progression, prognosis, and recurrence. Investigators review the most recent literature on IncRNAs involvement in CSC biology and function.
[Translational Oncology] |
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| Ryvu Therapeutics announced that its Clinical Trial Application to commence a single-agent, open-label Phase I/II trial, investigating the safety and efficacy of RVU120 in patients with relapsed/refractory metastatic or advanced solid tumors in Poland, has been fully approved.
[Ryvu Therapeutics] |
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| June 21 – 22, 2021
Virtual |
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| | UT Southwestern Medical Center – Dallas, Texas, United Statess |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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