Cancer Stem Cell News Volume 10.21 | Jun 2 2021







2021-06-02 | CSCN 10.21


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.21 – 2 June, 2021
TOP STORY

In Vivo Flow Cytometry Reveals a Circadian Rhythm of Circulating Tumor Cells

Scientists applied fluorescence in vivo flow cytometry to monitor circulating tumor cells noninvasively in an orthotopic mouse model of human prostate cancer.
[Light-Science & Applications]

Full Article

Explore scientific events this June with the Science Events Calendar.
PUBLICATIONSRanked by the impact factor of the journal

High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induced a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Oct4 Confers Stemness and Radioresistance to Head and Neck Squamous Cell Carcinoma by Regulating the Homologous Recombination Factors PSMC3IP and RAD54L

Investigators provided evidence that the CSC-related transcription factor Oct4 contributed to head and neck squamous cell carcinoma radioresistance by regulating DNA damage response and the CSC phenotype.
[Oncogene]

Full Article

FAK Inhibition Alone or in Combination with Adjuvant Therapies Reduces Cancer Stem Cell Activity

The authors determined the effect of focal adhesion kinase (FAK) inhibition on breast CSC activity alone and in combination with adjuvant therapies.
[npj Breast Cancer]

Full Article

MicroRNA-200c Restoration Reveals a Cytokine Profile to Enhance M1 Macrophage Polarization in Breast Cancer

To determine how triple negative breast cancer (TNBC) suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.
[npj Breast Cancer]

Full Article

Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells

Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
[International Journal of Molecular Sciences]

Full Article

Fatty Acid β-Oxidation Promotes Breast Cancer Stemness and Metastasis via the miRNA-328-3p-CPT1A Pathway

The authors found miR-328-3p to be significantly downregulated in breast cancer, revealing it as a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also as a model for the miRNA-fatty acid β-oxidation-stemness axis.
[Cancer Gene Therapy]

Full Article

CHK1 Inhibitor Sensitizes Resistant Colorectal Cancer Stem Cells to Nortopsentin

Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.
[iScience]

Full ArticleGraphical Abstract

BRM270 and Endostatin Synergistically Inhibit the Relapse of Non-Small Cell Lung Cancer While Suppressing Lung Cancer Stem Cells Proliferation Induced by Endostatin

Researchers clarified whether BRM270 could inhibit the proliferation of CSCs. Endostatin + BRM270 showed anti-tumor effects by reducing tumor volume and increasing survival.
[Molecular Therapy-Oncolytics]

AbstractFull ArticleGraphical Abstract

ETV4 Promotes Breast Cancer Cell Stemness by Activating Glycolysis and CXCR4-Mediated Sonic Hedgehog Signaling

Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
[Cell Death Discovery]

Full Article

NUMB Suppression by miR-9-5P Enhances CD44+ Prostate Cancer Stem Cell Growth and Metastasis

MiR-9-5p reduced NUMB expression and inhibited numerous prostate CSC properties including proliferation, migration, invasion as well as self-renewal.
[Scientific Reports]

Full Article

Survey results on the needs and challenges in the human pluripotent stem cell field
REVIEWS

Current Understanding of Epigenetics Mechanism as a Novel Target in Reducing Cancer Stem Cells Resistance

The authors explore recent information about the biology and characteristics of CSCs, including CSCs markers, CSCs niche, the relationship between epithelial to mesenchymal transition and CSCs, the factors that create resistance and influencing the generation of them.
[Clinical Epigenetics]

Full Article

Long Non-Coding RNAs in Cancer Stem Cells

LncRNAs have been involved in both CSC biology and cancer progression, prognosis, and recurrence. Investigators review the most recent literature on IncRNAs involvement in CSC biology and function.
[Translational Oncology]

AbstractFull ArticleGraphical Abstract

INDUSTRY AND POLICY NEWS

Ryvu Therapeutics Got Full Approval to Conduct Phase I/II Study of RVU120 (SEL120) in Patients with Relapsed/Refractory Metastatic or Advanced Solid Tumors in Poland

Ryvu Therapeutics announced that its Clinical Trial Application to commence a single-agent, open-label Phase I/II trial, investigating the safety and efficacy of RVU120 in patients with relapsed/refractory metastatic or advanced solid tumors in Poland, has been fully approved.
[Ryvu Therapeutics]

Press Release

FEATURED EVENT

Cancer Discovery Symposium

June 21 – 22, 2021
Virtual

> See All Events

JOB OPPORTUNITIES

Postdoctoral Positions – Hematopoiesis and Leukemia

UT Southwestern Medical Center – Dallas, Texas, United Statess

Director – The Roslin Institute

The University of Edinburgh – Edinburgh, Scotland, United Kingdom

Postdoctoral Position – Stemness Control in Pluripotent and Cancer Cells

Columbia University Medical Center – New York, New York, United States

Research Associate – Senescence in Cancer

University of Cambridge – Cambridge, England, United Kingdom

Faculty Positions – Immuno-Oncology

Medical College of Wisconsin – Milwaukee, Wisconsin, United States

> See All Jobs

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