Cancer Stem Cell News Volume 10.22 | Jun 9 2021

2021-06-09 | CSCN 10.22

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.22 – 9 June, 2021

Predicting Metastasis from Cues of Metastatic Cancer Stem-Like Cells-3D-Ultrasensitive Metasensor at a Single-Cell Level

Scientists generated an ultrasensitive 3D-metasensor to efficiently capture and investigate metastatic CSCs and magnified the vital premetastatic signals from a single cell.
[ACS Nano]

AbstractGraphical Abstract

Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
PUBLICATIONSRanked by the impact factor of the journal

High-Fat Diet-Activated Fatty Acid Oxidation Mediates Intestinal Stemness and Tumorigenicity

The authors proposed that a high-fat diet enhanced intestinal stemness and tumorigenicity by engaging a peroxisome proliferator-activated receptor-fatty acid oxidation program.
[Cell Reports]

Full Article

αSMA+ Fibroblasts Suppress Lgr5+ Cancer Stem Cells and Restrain Colorectal Cancer Progression

Scientists demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exerted tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.


RAL GTPases Mediate EGFR-Driven Intestinal Stem Cell Proliferation and Tumorigenesis

In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted EGFR-dependent tumorigenic growth in the intestine and in the human mammary epithelium.


The PI3K/mTOR Inhibitor Gedatolisib Eliminates Dormant Breast Cancer Cells in Organotypic Culture, but Fails to Prevent Metastasis in Preclinical Settings

By probing a number of kinases downstream of integrin-β1, researchers determined that PI3K inhibition with either a tool compound or a compound in clinical trials robustly sensitized quiescent breast tumor cells seeded in organotypic bone marrow cultures to chemotherapy.
[Molecular Oncology]

AbstractFull Article

Altered Lipid Metabolism Marks Glioblastoma Stem and Non-Stem Cells in Separate Tumor Niches

Investigators interrogated gene expression in separate microenvironments of glioblastoma organoid models that mimicked the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing.
[Acta Neuropathologica Communications]

Full Article

Activation of Wnt Signaling Reduces the Population of Cancer Stem Cells in Ameloblastoma

The authors identified a putative CSC population in immortalized and primary human ameloblastoma cells and examined possible therapeutic reagents to reduce the CSC population.
[Cell Proliferation]

Full Article

Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improved the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.
[Radiotherapy and Oncology]

AbstractGraphical Abstract

RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy

Researchers provided in vivo evidence that RAD51-Associated Protein 1(RAD51AP1) played a critical role in colorectal cancer (CRC) growth and drug resistance by regulating CRC stem cell self-renewal.
[Molecular Cancer Research]


Identification of Cancer Cell Stemness-Associated Long Noncoding RNAs for Predicting Prognosis of Patients with Hepatocellular Carcinoma

Cancer cell stemness-associated lncRNAs and their relevance in the prediction of clinical prognosis remain largely unexplored. Through the transcriptome-wide screen, scientists identified a total of 136 liver CSC-associated lncRNAs.
[DNA and Cell Biology]


New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.

Cancer Stem Cell–Immune Cell Crosstalk in Tumor Progression

The authors discuss the signaling programs that simultaneously induce CSCs and reprogram the immune response to facilitate tumor immune evasion, metastasis, and recurrence.
[Nature Reviews Cancer]


Tissue Mechanics in Stem Cell Fate, Development, and Cancer

Scientists review how dysregulation of tissue-level force increases the risk of malignancy, promotes tumor progression, and can induce a stem-like phenotype in tumor cells to drive tumor aggression and treatment resistance.
[Developmental Cell]

Full Article


bluebird bio Announces the Lifting of FDA Clinical Hold for Sickle Cell Disease and β-Thalassemia Studies

bluebird bio, Inc. announced that the FDA has lifted the clinical holds on the Phase I/II HGB-206 and Phase III HGB-210 studies of LentiGlobin for sickle cell disease (SCD) gene therapy (bb1111) for adult and pediatric patients with SCD, and the Phase 3 Northstar-2 and Northstar-3 studies of betibeglogene autotemcel gene therapy for adult, adolescent and pediatric patients with transfusion-dependent β-thalassemia.
[bluebird bio, Inc.]

Press Release


EMBO Workshop: Cell Size and Growth Regulation

June 21 – 24, 2021

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Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

City of Hope – CMonrovia, California, United States

Research Technologist – Neurological Surgery

Northwestern University – Chicago, Illinois, United States

Postdoctoral Positions – Hematopoiesis and Leukemia

UT Southwestern Medical Center – Dallas, Texas, United Statess

Director – The Roslin Institute

The University of Edinburgh – Edinburgh, Scotland, United Kingdom

Postdoctoral Position – Stemness Control in Pluripotent and Cancer Cells

Columbia University Medical Center – New York, New York, United States

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