Cancer Stem Cell News Volume 10.26 | Jul 7 2021


    2021-07-07 | CSCN 10.26

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.26 – 7 July, 2021

    Inhibiting DNA-PK Induces Glioma Stem Cell Differentiation and Sensitizes Glioblastoma to Radiation in Mice

    Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.
    [Science Translational Medicine]


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    Dual Role of WNT5A in Promoting Endothelial Differentiation of Glioma Stem Cells and Angiogenesis of Glioma Derived Endothelial Cells

    Researchers reported that wingless-related integration site family member 5A (WNT5A) played significant roles in glioma stem cell endothelial differentiation and glioma-derived endothelial cells’ angiogenesis.


    ZEB2 Facilitates Peritoneal Metastasis by Regulating the Invasiveness and Tumorigenesis of Cancer Stem-Like Cells in High-Grade Serous Ovarian Cancers

    Investigators demonstrated that ZEB2, the transcription factor of epithelial-mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.

    Full Article

    RBM5-AS1 Promotes Radioresistance in Medulloblastoma through Stabilization of SIRT6 Protein

    The authors profiled CSC-related long non-coding RNAs (lncRNAs) between radioresistant and parental medulloblastoma cells. The roles of the lncRNA RBM5-AS1 in the stemness and radiosensitivity of medulloblastoma cells were investigated.
    [Acta Neuropathologica Communications]

    Full Article

    Small Cell Lung Cancer Stem Cells Display Mesenchymal Properties and Exploit Immune Checkpoint Pathways in Activated Cytotoxic T Lymphocytes

    To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.
    [Cancer Immunology, Immunotherapy]

    Full Article

    CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis

    The authors assessed whether circulating tumor cells (CTCs) in peripheral blood could serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for brain metastases.
    [International Journal of Molecular Sciences]

    Full Article

    3-Hydroxyanthranic Acid Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Decreasing Tumor Cell Stemness

    Researchers demonstrated that 3-HAA sensitized hepatocellular carcinoma cells to sorafenib by reducing tumor stemness.
    [Cell Death Discovery]

    Full Article

    Heterotypic Clustering of Circulating Tumor Cells and Circulating Cancer-Associated Fibroblasts Facilitates Breast Cancer Metastasis

    Investigators reported that dissemination of circulating tumor cells, circulating cancer-associated fibroblasts, and clusters were an early event in breast cancer (BC) progression, and they found these clusters in all clinical stages of BC.
    [Breast Cancer Research and Treatment]


    FGFR2 Maintains Cancer Cell Differentiation via AKT Signaling in Esophageal Squamous Cell Carcinoma

    Scientists showed that fibroblast growth factor receptor 2 (FGFR2), particularly the IIIb isoform, was highly expressed in non-CSCs.
    [Cancer Biology & Therapy]


    M2-Like Tumor-Associated Macrophage-Secreted IGF Promotes Thyroid Cancer Stemness and Metastasis by Activating the PI3K/AKT/mTOR Pathway

    M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.
    [Molecular Medicine Reports]

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    Molecular and Circulating Biomarkers of Brain Tumors

    The authors review available literature on plasma circulating tumor cells, cell-free tumors, circulating cell-free microRNAs, and circulating extracellular vesicles for the diagnosis and monitoring of brain tumors.
    [International Journal of Molecular Sciences]

    Full Article


    Trillium Therapeutics Announces Dosing of First Patient in Phase Ib/II Study of TTI-622 in Combination with Azacitidine and Venetoclax in TP53-Wild Type Acute Myeloid Leukemia

    Trillium Therapeutics, Inc. announced that it has dosed the first acute myeloid leukemia patient with TTI-622, an investigational checkpoint inhibitor of the innate immune system, in combination with azacitidine and venetoclax.
    [Trillium Therapeutics, Inc.]

    Press Release


    i-Vaccines 2021: International Vaccines & Virology Conference

    October 14 – 15, 2021
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    Postdoctoral Associate – Anti-Cancer Nanorings

    University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States

    Postdoctoral Research Scientist – Colorectal Cancer and Wnt Signaling

    Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

    Senior Scientific Officer – Colorectal Cancer

    Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

    Research Assistant – Cancer Biology

    Eastern Virginia Medical School – Norfolk, Virginia, United States

    Postdoctoral Scientist – Childhood Cancer Research

    Nationwide Children’s Hospital – Columbus, Ohio, United States

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