 | | Vol. 10.26 – 7 July, 2021 |
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| Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that wingless-related integration site family member 5A (WNT5A) played significant roles in glioma stem cell endothelial differentiation and glioma-derived endothelial cells’ angiogenesis.
[Oncogene] |
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| Investigators demonstrated that ZEB2, the transcription factor of epithelial-mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.
[Oncogene] |
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| The authors profiled CSC-related long non-coding RNAs (lncRNAs) between radioresistant and parental medulloblastoma cells. The roles of the lncRNA RBM5-AS1 in the stemness and radiosensitivity of medulloblastoma cells were investigated.
[Acta Neuropathologica Communications] |
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| To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.
[Cancer Immunology, Immunotherapy] |
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| The authors assessed whether circulating tumor cells (CTCs) in peripheral blood could serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for brain metastases.
[International Journal of Molecular Sciences] |
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| Researchers demonstrated that 3-HAA sensitized hepatocellular carcinoma cells to sorafenib by reducing tumor stemness.
[Cell Death Discovery] |
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| Investigators reported that dissemination of circulating tumor cells, circulating cancer-associated fibroblasts, and clusters were an early event in breast cancer (BC) progression, and they found these clusters in all clinical stages of BC.
[Breast Cancer Research and Treatment] |
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| Scientists showed that fibroblast growth factor receptor 2 (FGFR2), particularly the IIIb isoform, was highly expressed in non-CSCs.
[Cancer Biology & Therapy] |
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| M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.
[Molecular Medicine Reports] |
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| The authors review available literature on plasma circulating tumor cells, cell-free tumors, circulating cell-free microRNAs, and circulating extracellular vesicles for the diagnosis and monitoring of brain tumors.
[International Journal of Molecular Sciences] |
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| Trillium Therapeutics, Inc. announced that it has dosed the first acute myeloid leukemia patient with TTI-622, an investigational checkpoint inhibitor of the innate immune system, in combination with azacitidine and venetoclax.
[Trillium Therapeutics, Inc.] |
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| October 14 – 15, 2021
London, England, United Kingdom |
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| | University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Eastern Virginia Medical School – Norfolk, Virginia, United States |
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| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
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