Cancer Stem Cell News Volume 10.26 | Jul 7 2021







2021-07-07 | CSCN 10.26


Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.26 – 7 July, 2021
TOP STORY

Inhibiting DNA-PK Induces Glioma Stem Cell Differentiation and Sensitizes Glioblastoma to Radiation in Mice

Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.
[Science Translational Medicine]

Abstract

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Dual Role of WNT5A in Promoting Endothelial Differentiation of Glioma Stem Cells and Angiogenesis of Glioma Derived Endothelial Cells

Researchers reported that wingless-related integration site family member 5A (WNT5A) played significant roles in glioma stem cell endothelial differentiation and glioma-derived endothelial cells’ angiogenesis.
[Oncogene]

Abstract

ZEB2 Facilitates Peritoneal Metastasis by Regulating the Invasiveness and Tumorigenesis of Cancer Stem-Like Cells in High-Grade Serous Ovarian Cancers

Investigators demonstrated that ZEB2, the transcription factor of epithelial-mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.
[Oncogene]

Full Article

RBM5-AS1 Promotes Radioresistance in Medulloblastoma through Stabilization of SIRT6 Protein

The authors profiled CSC-related long non-coding RNAs (lncRNAs) between radioresistant and parental medulloblastoma cells. The roles of the lncRNA RBM5-AS1 in the stemness and radiosensitivity of medulloblastoma cells were investigated.
[Acta Neuropathologica Communications]

Full Article

Small Cell Lung Cancer Stem Cells Display Mesenchymal Properties and Exploit Immune Checkpoint Pathways in Activated Cytotoxic T Lymphocytes

To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.
[Cancer Immunology, Immunotherapy]

Full Article

CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis

The authors assessed whether circulating tumor cells (CTCs) in peripheral blood could serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for brain metastases.
[International Journal of Molecular Sciences]

Full Article

3-Hydroxyanthranic Acid Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Decreasing Tumor Cell Stemness

Researchers demonstrated that 3-HAA sensitized hepatocellular carcinoma cells to sorafenib by reducing tumor stemness.
[Cell Death Discovery]

Full Article

Heterotypic Clustering of Circulating Tumor Cells and Circulating Cancer-Associated Fibroblasts Facilitates Breast Cancer Metastasis

Investigators reported that dissemination of circulating tumor cells, circulating cancer-associated fibroblasts, and clusters were an early event in breast cancer (BC) progression, and they found these clusters in all clinical stages of BC.
[Breast Cancer Research and Treatment]

Abstract

FGFR2 Maintains Cancer Cell Differentiation via AKT Signaling in Esophageal Squamous Cell Carcinoma

Scientists showed that fibroblast growth factor receptor 2 (FGFR2), particularly the IIIb isoform, was highly expressed in non-CSCs.
[Cancer Biology & Therapy]

Abstract

M2-Like Tumor-Associated Macrophage-Secreted IGF Promotes Thyroid Cancer Stemness and Metastasis by Activating the PI3K/AKT/mTOR Pathway

M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.
[Molecular Medicine Reports]

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REVIEWS

Molecular and Circulating Biomarkers of Brain Tumors

The authors review available literature on plasma circulating tumor cells, cell-free tumors, circulating cell-free microRNAs, and circulating extracellular vesicles for the diagnosis and monitoring of brain tumors.
[International Journal of Molecular Sciences]

Full Article

INDUSTRY AND POLICY NEWS

Trillium Therapeutics Announces Dosing of First Patient in Phase Ib/II Study of TTI-622 in Combination with Azacitidine and Venetoclax in TP53-Wild Type Acute Myeloid Leukemia

Trillium Therapeutics, Inc. announced that it has dosed the first acute myeloid leukemia patient with TTI-622, an investigational checkpoint inhibitor of the innate immune system, in combination with azacitidine and venetoclax.
[Trillium Therapeutics, Inc.]

Press Release

FEATURED EVENT

i-Vaccines 2021: International Vaccines & Virology Conference

October 14 – 15, 2021
London, England, United Kingdom

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JOB OPPORTUNITIES

Postdoctoral Associate – Anti-Cancer Nanorings

University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States

Postdoctoral Research Scientist – Colorectal Cancer and Wnt Signaling

Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

Senior Scientific Officer – Colorectal Cancer

Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

Research Assistant – Cancer Biology

Eastern Virginia Medical School – Norfolk, Virginia, United States

Postdoctoral Scientist – Childhood Cancer Research

Nationwide Children’s Hospital – Columbus, Ohio, United States

> See All Jobs

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