 | | Vol. 10.27 – 14 July, 2021 |
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| The authors demonstrated that coordinated regulation of both isoforms through control of splicing was essential for development of Kras mutant tumors. The minor KRAS4A isoform was enriched in cancer stem-like cells, where it responded to hypoxia, while the major KRAS4B was induced by ER stress.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
[Nature Communications] |
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| Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitated the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.
[ACS Applied Materials & Interfaces] |
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| Using a murine chronic myeloid leukemia (CML) model, the authors examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced hematopoietic stem cell supportive capacity.
[Cell Reports] |
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| Scientists identified the consistent transcriptome of primary breast cancer stem cells (BCSCs) shared across breast cancer subtypes and examined the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.
[British Journal of Cancer] |
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| The authors suggested that homeobox B9 (HOXB9) may have contributed to prostate cancer tumorigenesis and metastasis via transforming growth factor beta signaling.
[British Journal of Cancer] |
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| Scientists investigated the regulatory role of exosomal miR-944 derived from glioma stem cells in glioma progression and angiogenesis.
[Aging] |
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| Long non-coding RNAs and miRNAs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Researchers explored the underlying roles of LINC00115 and miRNA-30a in OC.
[Cancer Cell International] |
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| The roles of small extracellular vesicles (sEVs) from cancer-associated fibroblasts on breast CSC properties are largely unraveled. Investigators explored the roles of sEVs from cancer-associated fibroblasts on breast cancer progression.
[Cell Death Discovery] |
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The authors describe cancer-initiating cells’ (CICs) contribution to cancer progression and discuss mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage.
[Stem Cell Reviews and Reports] |
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| GlycoMimetics, Inc. has announced that clinicians at the University of California Davis Comprehensive Cancer Center initiated dosing of the first patient in a clinical study of uproleselan combined with venetoclax and azacitidine for the treatment of older or unfit patients with treatment-naïve acute myeloid leukemia.
[GlycoMimetics, Inc] |
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| October 27 – 29, 2021
Tokyo, Japan |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | UC San Diego School of Medicine – San Diego, California, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States |
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| | Eastern Virginia Medical School – Norfolk, Virginia, United States |
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