Cancer Stem Cell News Volume 10.27 | Jul 14 2021


    2021-07-14 | CSCN 10.27

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.27 – 14 July, 2021

    Targeting KRAS4A Splicing through the RBM39/DCAF15 Pathway Inhibits Cancer Stem Cells

    The authors demonstrated that coordinated regulation of both isoforms through control of splicing was essential for development of Kras mutant tumors. The minor KRAS4A isoform was enriched in cancer stem-like cells, where it responded to hypoxia, while the major KRAS4B was induced by ER stress.
    [Nature Communications]

    Full Article

    Survey results on the needs and challenges in the human pluripotent stem cell field
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Matrix Protein-1 Secretory Isoform Promotes Ovarian Cancer through Increasing Alternative mRNA Splicing and Stemness

    Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.
    [Nature Communications]

    Full Article

    Induction Therapy of Retinoic Acid with a Temozolomide-Loaded Gold Nanoparticle-Associated Ultrasound Effect on Glioblastoma Cancer Stem-Like Colonies

    Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitated the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    TNF-α-Induced Alterations in Stromal Progenitors Enhance Leukemic Stem Cell Growth via CXCR2 Signaling

    Using a murine chronic myeloid leukemia (CML) model, the authors examined leukemia-induced alterations in mesenchymal cell populations and showed that 6C3+ stromal progenitors expanded in CML bone marrow and exhibited increased leukemia stem cells but reduced hematopoietic stem cell supportive capacity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Transcriptome Profiles of Stem-Like Cells from Primary Breast Cancers Allow Identification of ITGA7 as a Predictive Marker of Chemotherapy Response

    Scientists identified the consistent transcriptome of primary breast cancer stem cells (BCSCs) shared across breast cancer subtypes and examined the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.
    [British Journal of Cancer]

    Full Article

    Insights Into Homeobox B9: A Propeller for Metastasis in Dormant Prostate Cancer Progenitor Cells

    The authors suggested that homeobox B9 (HOXB9) may have contributed to prostate cancer tumorigenesis and metastasis via transforming growth factor beta signaling.
    [British Journal of Cancer]

    Full Article

    Glioma Stem Cell-Derived Exosomal miR-944 Reduces Glioma Growth and Angiogenesis by Inhibiting AKT/ERK Signaling

    Scientists investigated the regulatory role of exosomal miR-944 derived from glioma stem cells in glioma progression and angiogenesis.

    Full Article

    LINC00115 Promotes Stemness and Inhibits Apoptosis of Ovarian Cancer Stem Cells by Upregulating SOX9 and Inhibiting the Wnt/β-Catenin Pathway through Competitively Binding to microRNA-30a

    Long non-coding RNAs and miRNAs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Researchers explored the underlying roles of LINC00115 and miRNA-30a in OC.
    [Cancer Cell International]

    Full Article

    Carcinoma Associated Fibroblasts Small Extracellular Vesicles with Low miR-7641 Promotes Breast Cancer Stemness and Glycolysis by HIF-1α

    The roles of small extracellular vesicles (sEVs) from cancer-associated fibroblasts on breast CSC properties are largely unraveled. Investigators explored the roles of sEVs from cancer-associated fibroblasts on breast cancer progression.
    [Cell Death Discovery]

    Full Article

    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation

    Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor Progression

    The authors describe cancer-initiating cells’ (CICs) contribution to cancer progression and discuss mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract


    GlycoMimetics Announces Initiation of Clinical Trial Evaluating Uproleselan in Combination with Venetoclax and Azacitidine

    GlycoMimetics, Inc. has announced that clinicians at the University of California Davis Comprehensive Cancer Center initiated dosing of the first patient in a clinical study of uproleselan combined with venetoclax and azacitidine for the treatment of older or unfit patients with treatment-naïve acute myeloid leukemia.
    [GlycoMimetics, Inc]

    Press Release


    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

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    Scientist – Pathology and Laboratory Medicine

    Medical University of South Carolina – Charleston, South Carolina, United States

    Research Associate – Cancer Stem Cell Biology

    UC San Diego School of Medicine – San Diego, California, United States

    Postdoctoral Researcher – Stem Cells, Organoids, and Systems Biology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Associate – Anti-Cancer Nanorings

    University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States

    Research Assistant – Cancer Biology

    Eastern Virginia Medical School – Norfolk, Virginia, United States

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