 | | Vol. 10.30 – 4 August, 2021 |
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| Scientists found STAT5B to be specifically activated in HSCs and leukemic stem cells, where it induced many genes associated with quiescence and self-renewal, including the surface marker CD9.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors described a novel multi-kinase inhibitor, 108600, that suppressed growth, colony and mammosphere forming capacity of breast cancer stem cell-like cells and induced G2M arrest and apoptosis of triple-negative breast cancer cells.
[Nature Communications] |
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| Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.
[Cell Reports] |
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| Macrophages co-cultured with breast cancer cells showed a significant increase in CCL2 expression and promoted β-Catenin-induced breast cancer stem cells (BCSCs) properties, whereas depletion of CCL2 by adding neutralizing antibodies suppressed BSCSs properties.
[Oncogene] |
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| The authors examined the expression of RNF141 in 64 pairs of colorectal cancer and adjacent normal tissues by real-time PCR, Western blot, and immunohistochemical analysis.
[Oncogene] |
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| To identify drivers of sarcoma cancer stem-like cells, investigators compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease] |
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| Researchers showed that sublethal doxorubicin treatment led to increased migration and invasion in otherwise non-invasive MCF7 breast cancer cells.
[Breast Cancer Research] |
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| An ovarian cancer cell line, PEO4, was initially reprogrammed into induced pluripotent stem cells using the classical four factors OCT4, SOX2, KLF4 and MYC using lentivirus transduction.
[International Journal of Biochemistry & Cell Biology] |
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| Different concentrations of doxorubicin (DOX), graphene oxide, and graphene oxide plus doxorubicin (GO-DOX) were subjected to MCF7 and BT474 human breast cancer cells at specified intervals.
[Applied Biochemistry and Biotechnology] |
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| Investigators discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.
[Journal of Experimental & Clinical Cancer Research] |
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| Calidi Biotherapeutics, Inc., announced that it has executed a license agreement with Northwestern University for the exclusive commercialization rights to the IND and data generated from Northwestern’s Phase 1 clinical trial treating brain tumor patients with an engineered oncolytic adenovirus delivered by neural stem cells.
[Calidi Biotherapeutics, Inc.] |
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| Ambrx announced the first patient has been dosed in a Phase I, multicenter, open-label, dose-escalation, and dose expansion study to evaluate the safety, pharmacokinetics, and anti-tumor activity of ARX517 in subjects with prostate specific membrane antigen (PSMA) expressing tumors found in prostate, pancreatic, lung and ovarian cancers.
[Ambrx (BusinessWire, Inc.)] |
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| October 21 – 22, 2021
Virtual |
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| Pfizer, Inc. – Boulder, Colorado; New York City, New York; San Francisco, California, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Westwood Bioscience, Inc. – Los Angeles, California, United States |
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| | University of Gothenburg – Gothenburg, Sweden |
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| CRUK Manchester Institute – Manchester, England, United Kingdom |
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