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Vol. 10.30 – 4 August, 2021
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Scientists found STAT5B to be specifically activated in HSCs and leukemic stem cells, where it induced many genes associated with quiescence and self-renewal, including the surface marker CD9.
[Blood]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors described a novel multi-kinase inhibitor, 108600, that suppressed growth, colony and mammosphere forming capacity of breast cancer stem cell-like cells and induced G2M arrest and apoptosis of triple-negative breast cancer cells.
[Nature Communications]
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Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.
[Cell Reports]
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Macrophages co-cultured with breast cancer cells showed a significant increase in CCL2 expression and promoted β-Catenin-induced breast cancer stem cells (BCSCs) properties, whereas depletion of CCL2 by adding neutralizing antibodies suppressed BSCSs properties.
[Oncogene]
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The authors examined the expression of RNF141 in 64 pairs of colorectal cancer and adjacent normal tissues by real-time PCR, Western blot, and immunohistochemical analysis.
[Oncogene]
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To identify drivers of sarcoma cancer stem-like cells, investigators compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease]
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Researchers showed that sublethal doxorubicin treatment led to increased migration and invasion in otherwise non-invasive MCF7 breast cancer cells.
[Breast Cancer Research]
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An ovarian cancer cell line, PEO4, was initially reprogrammed into induced pluripotent stem cells using the classical four factors OCT4, SOX2, KLF4 and MYC using lentivirus transduction.
[International Journal of Biochemistry & Cell Biology]
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Different concentrations of doxorubicin (DOX), graphene oxide, and graphene oxide plus doxorubicin (GO-DOX) were subjected to MCF7 and BT474 human breast cancer cells at specified intervals.
[Applied Biochemistry and Biotechnology]
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Investigators discuss the role of hypoxia facilitating senescence bypass during malignant transformation and acquisition of stemness properties, which all contribute to tumor development and cancer disease aggressiveness.
[Journal of Experimental & Clinical Cancer Research]
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Calidi Biotherapeutics, Inc., announced that it has executed a license agreement with Northwestern University for the exclusive commercialization rights to the IND and data generated from Northwestern’s Phase 1 clinical trial treating brain tumor patients with an engineered oncolytic adenovirus delivered by neural stem cells.
[Calidi Biotherapeutics, Inc.]
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Ambrx announced the first patient has been dosed in a Phase I, multicenter, open-label, dose-escalation, and dose expansion study to evaluate the safety, pharmacokinetics, and anti-tumor activity of ARX517 in subjects with prostate specific membrane antigen (PSMA) expressing tumors found in prostate, pancreatic, lung and ovarian cancers.
[Ambrx (BusinessWire, Inc.)]
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October 21 – 22, 2021
Virtual
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Pfizer, Inc. – Boulder, Colorado; New York City, New York; San Francisco, California, United States
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The University of British Columbia – Vancouver, British Columbia, Canada
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Westwood Bioscience, Inc. – Los Angeles, California, United States
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University of Gothenburg – Gothenburg, Sweden
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CRUK Manchester Institute – Manchester, England, United Kingdom
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News
